GNAI2_MOUSE - dbPTM
GNAI2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GNAI2_MOUSE
UniProt AC P08752
Protein Name Guanine nucleotide-binding protein G(i) subunit alpha-2
Gene Name Gnai2
Organism Mus musculus (Mouse).
Sequence Length 355
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Membrane
Lipid-anchor . Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody (By similarity)..
Protein Description Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division..
Protein Sequence MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPQRADDARQLFALSCAAEEQGMLPEDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITQSSLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Myristoylation------MGCTVSAED
------CCCCCCHHH		18.79-
3S-palmitoylation-----MGCTVSAEDK
-----CCCCCCHHHH		3.07-
10UbiquitinationCTVSAEDKAAAERSK
CCCCHHHHHHHHHHH		31.28-
21UbiquitinationERSKMIDKNLREDGE
HHHHHHCHHHHHHHH		47.1327667366
29UbiquitinationNLREDGEKAAREVKL
HHHHHHHHHHHHHHH		53.5322790023
35AcetylationEKAAREVKLLLLGAG
HHHHHHHHHHEECCC		28.7623236377
35UbiquitinationEKAAREVKLLLLGAG
HHHHHHHHHHEECCC		28.7622790023
44PhosphorylationLLLGAGESGKSTIVK
HEECCCCCCCCHHHH		51.0722817900
46UbiquitinationLGAGESGKSTIVKQM
ECCCCCCCCHHHHEE		54.4222790023
47PhosphorylationGAGESGKSTIVKQMK
CCCCCCCCHHHHEEE		27.2229899451
48PhosphorylationAGESGKSTIVKQMKI
CCCCCCCHHHHEEEE		33.02-
51UbiquitinationSGKSTIVKQMKIIHE
CCCCHHHHEEEEECC		40.6027667366
61PhosphorylationKIIHEDGYSEEECRQ
EEECCCCCCHHHHHH		25.8222817900
62PhosphorylationIIHEDGYSEEECRQY
EECCCCCCHHHHHHH		44.0230635358
66GlutathionylationDGYSEEECRQYRAVV
CCCCHHHHHHHHHHH		3.5824333276
66S-nitrosylationDGYSEEECRQYRAVV
CCCCHHHHHHHHHHH		3.5820925432
66S-nitrosocysteineDGYSEEECRQYRAVV
CCCCHHHHHHHHHHH		3.58-
69PhosphorylationSEEECRQYRAVVYSN
CHHHHHHHHHHHCHH		4.9225367039
75PhosphorylationQYRAVVYSNTIQSIM
HHHHHHCHHHHHHHH		18.8520139300
112GlutathionylationRQLFALSCAAEEQGM
HHHHHHHHHHHHCCC		4.2924333276
140S-palmitoylationADHGVQACFGRSREY
HHHCHHHHCCCCCCE		1.7628526873
140S-nitrosylationADHGVQACFGRSREY
HHHCHHHHCCCCCCE		1.7620925432
140S-nitrosocysteineADHGVQACFGRSREY
HHHCHHHHCCCCCCE		1.76-
140GlutathionylationADHGVQACFGRSREY
HHHCHHHHCCCCCCE		1.7624333276
166PhosphorylationDLERIAQSDYIPTQQ
HHHHHHHCCCCCCHH		24.2925159016
168PhosphorylationERIAQSDYIPTQQDV
HHHHHCCCCCCHHHH		17.6625159016
171PhosphorylationAQSDYIPTQQDVLRT
HHCCCCCCHHHHHHH		29.3325159016
181UbiquitinationDVLRTRVKTTGIVET
HHHHHHHCCCCEEEE		36.76-
188PhosphorylationKTTGIVETHFTFKDL
CCCCEEEEEEEECCE		16.05-
191PhosphorylationGIVETHFTFKDLHFK
CEEEEEEEECCEEEE		23.36-
193UbiquitinationVETHFTFKDLHFKMF
EEEEEEECCEEEEEE		57.2122790023
198UbiquitinationTFKDLHFKMFDVGGQ
EECCEEEEEEECCCC		28.1022790023
207PhosphorylationFDVGGQRSERKKWIH
EECCCCCCCHHHHHH		33.5922817900
249UbiquitinationNRMHESMKLFDSICN
HHHHHHHHHHHHHHC		56.1122790023
253PhosphorylationESMKLFDSICNNKWF
HHHHHHHHHHCCCCC		23.0029899451
255S-palmitoylationMKLFDSICNNKWFTD
HHHHHHHHCCCCCCC		5.4828526873
272UbiquitinationIILFLNKKDLFEEKI
EEEEEEHHHHHHHHC		59.6022790023
282PhosphorylationFEEKITQSSLTICFP
HHHHCCCCCEEEECC		20.75-
283PhosphorylationEEKITQSSLTICFPE
HHHCCCCCEEEECCC		21.5125521595
296UbiquitinationPEYTGANKYDEAASY
CCCCCCCCHHHHHHH		54.2522790023
307UbiquitinationAASYIQSKFEDLNKR
HHHHHHHHHHHHHCC		36.0822790023
313UbiquitinationSKFEDLNKRKDTKEI
HHHHHHHCCCCCCHH		69.0322790023
326S-nitrosocysteineEIYTHFTCATDTKNV
HHHHHEEECCCCCCC		3.62-
326GlutathionylationEIYTHFTCATDTKNV
HHHHHEEECCCCCCC		3.6224333276
326S-nitrosylationEIYTHFTCATDTKNV
HHHHHEEECCCCCCC		3.6220925432
346UbiquitinationAVTDVIIKNNLKDCG
HHHHHHHHCCCCCCC		28.76-
350UbiquitinationVIIKNNLKDCGLF--
HHHHCCCCCCCCC--		53.7722790023
352S-palmitoylationIKNNLKDCGLF----
HHCCCCCCCCC----		4.9528680068
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GNAI2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GNAI2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GNAI2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GNAI2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GNAI2_MOUSE

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Related Literatures of Post-Translational Modification

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