EZRI_MOUSE - dbPTM
EZRI_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EZRI_MOUSE
UniProt AC P26040
Protein Name Ezrin
Gene Name Ezr
Organism Mus musculus (Mouse).
Sequence Length 586
Subcellular Localization Apical cell membrane
Peripheral membrane protein
Cytoplasmic side . Cell projection . Cell projection, microvillus membrane
Peripheral membrane protein
Cytoplasmic side . Cell projection, ruffle membrane
Peripheral membrane protein
Cytoplasmic
Protein Description Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity)..
Protein Sequence MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLQYVDNKGFPTWLKLDKKVSAQEVRKENPVQFKFRAKFYPEDVAEELIQDITQKLFFLQVKDGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEMHKSGYLSSERLIPQRVMDQHKLSRDQWEDRIQVWHAEHRGMLKDSAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMLREKEELMLRLQDYEQKTKRAEKELSEQIEKALQLEEERRRAQEEAERLEADRMAALRAKEELERQAQDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVNYHVQEGLQDEGAEPMGYSAELSSEGILDDRNEEKRITEAEKNERVQRQLLTLSNELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Ubiquitination-----MPKPINVRVT
-----CCCCEEEEEE		58.17-
3Malonylation-----MPKPINVRVT
-----CCCCEEEEEE		58.1726320211
35AcetylationQLFDQVVKTIGLREV
HHHHHHHHHHCCCHH		35.2522826441
57PhosphorylationVDNKGFPTWLKLDKK
ECCCCCCCEEECCCC		40.9622817900
60AcetylationKGFPTWLKLDKKVSA
CCCCCEEECCCCCCH		46.32-
60PhosphoglycerylationKGFPTWLKLDKKVSA
CCCCCEEECCCCCCH		46.32-
72UbiquitinationVSAQEVRKENPVQFK
CCHHHHHHHCCCCEE		68.0022790023
79UbiquitinationKENPVQFKFRAKFYP
HHCCCCEEEEECCCC		19.4922790023
83UbiquitinationVQFKFRAKFYPEDVA
CCEEEEECCCCHHHH		40.97-
139UbiquitinationAKFGDYNKEMHKSGY
HHHCCCCHHHHHCCC		50.6222790023
143UbiquitinationDYNKEMHKSGYLSSE
CCCHHHHHCCCCCCC		44.2422790023
144PhosphorylationYNKEMHKSGYLSSER
CCHHHHHCCCCCCCC		20.2828973931
146PhosphorylationKEMHKSGYLSSERLI
HHHHHCCCCCCCCCC		15.5322817900
148PhosphorylationMHKSGYLSSERLIPQ
HHHCCCCCCCCCCCH		22.9728973931
162UbiquitinationQRVMDQHKLSRDQWE
HHHHHHHCCCHHHHH		42.3922790023
184UbiquitinationAEHRGMLKDSAMLEY
HHHCCCCCCHHHHHH		40.5222790023
191PhosphorylationKDSAMLEYLKIAQDL
CCHHHHHHHHHHHHH		14.88-
209UbiquitinationGINYFEIKNKKGTDL
CCCEEEEECCCCCCE		56.3622790023
235PhosphorylationYEKDDKLTPKIGFPW
EECCCCCCCCCCCCH		28.4222817900
237UbiquitinationKDDKLTPKIGFPWSE
CCCCCCCCCCCCHHH		50.6722790023
237AcetylationKDDKLTPKIGFPWSE
CCCCCCCCCCCCHHH		50.6722826441
249PhosphorylationWSEIRNISFNDKKFV
HHHHCCCCCCCCEEE		22.8828285833
253UbiquitinationRNISFNDKKFVIKPI
CCCCCCCCEEEEEEC		49.57-
253MalonylationRNISFNDKKFVIKPI
CCCCCCCCEEEEEEC		49.5726320211
253AcetylationRNISFNDKKFVIKPI
CCCCCCCCEEEEEEC		49.5723236377
254MalonylationNISFNDKKFVIKPID
CCCCCCCEEEEEECC		47.9626320211
254AcetylationNISFNDKKFVIKPID
CCCCCCCEEEEEECC		47.9622826441
258AcetylationNDKKFVIKPIDKKAP
CCCEEEEEECCCCCC		30.5322826441
262AcetylationFVIKPIDKKAPDFVF
EEEEECCCCCCCCEE		52.1022826441
263MalonylationVIKPIDKKAPDFVFY
EEEECCCCCCCCEEE		62.4926320211
263UbiquitinationVIKPIDKKAPDFVFY
EEEECCCCCCCCEEE		62.49-
263AcetylationVIKPIDKKAPDFVFY
EEEECCCCCCCCEEE		62.4922826441
270PhosphorylationKAPDFVFYAPRLRIN
CCCCCEEEECCHHCC		15.4729899451
291PhosphorylationCMGNHELYMRRRKPD
HCCCHHHHHCCCCCC		5.89-
299PhosphorylationMRRRKPDTIEVQQMK
HCCCCCCCHHHHHHH		27.8025338131
306UbiquitinationTIEVQQMKAQAREEK
CHHHHHHHHHHHHHH		32.7722790023
332PhosphorylationTEKKRRETVEREKEQ
HHHHHHHHHHHHHHH		26.3429899451
337UbiquitinationRETVEREKEQMLREK
HHHHHHHHHHHHHHH		60.5122790023
344UbiquitinationKEQMLREKEELMLRL
HHHHHHHHHHHHHHH		50.4822790023
354PhosphorylationLMLRLQDYEQKTKRA
HHHHHHHHHHHHHHH		13.8022817900
363UbiquitinationQKTKRAEKELSEQIE
HHHHHHHHHHHHHHH		64.0722790023
363AcetylationQKTKRAEKELSEQIE
HHHHHHHHHHHHHHH		64.0723806337
366PhosphorylationKRAEKELSEQIEKAL
HHHHHHHHHHHHHHH		28.66-
371UbiquitinationELSEQIEKALQLEEE
HHHHHHHHHHHHHHH		56.9022790023
412UbiquitinationRQAQDQIKSQEQLAA
HHHHHHHHHHHHHHH		40.2222790023
424PhosphorylationLAAELAEYTAKIALL
HHHHHHHHHHHHHHH		13.3428973931
438UbiquitinationLEEARRRKEDEVEEW
HHHHHHCCHHHHHHH		68.6422790023
450UbiquitinationEEWQHRAKEAQDDLV
HHHHHHHHHHHHHHH		54.2422790023
458UbiquitinationEAQDDLVKTKEELHL
HHHHHHHCCHHHHEE		62.2622790023
478PhosphorylationPPPPPPVYEPVNYHV
CCCCCCCCCCCCHHH		21.9322817900
483PhosphorylationPVYEPVNYHVQEGLQ
CCCCCCCHHHHCCCC		12.0022817900
523UbiquitinationKRITEAEKNERVQRQ
HCCCHHHHHHHHHHH		71.7722790023
533PhosphorylationRVQRQLLTLSNELSQ
HHHHHHHHHHHHHHH		36.4128285833
535PhosphorylationQRQLLTLSNELSQAR
HHHHHHHHHHHHHHH		24.0321082442
539PhosphorylationLTLSNELSQARDENK
HHHHHHHHHHHHHCC		18.6727600695
546UbiquitinationSQARDENKRTHNDII
HHHHHHCCCCHHHHC		57.5422790023
565PhosphorylationMRQGRDKYKTLRQIR
HHCCHHHHHHHHHHH		17.3129514104
567PhosphorylationQGRDKYKTLRQIRQG
CCHHHHHHHHHHHCC		24.8815196952
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
146YPhosphorylationKinasePDGFR-Uniprot
235TPhosphorylationKinaseCDK5P49615
PSP
354YPhosphorylationKinasePDGFR-Uniprot
478YPhosphorylationKinaseSRCP12931
PSP
567TPhosphorylationKinasePRKCIP41743
GPS
567TPhosphorylationKinasePRKCIQ62074
Uniprot
567TPhosphorylationKinaseROCK2P70336
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EZRI_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EZRI_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MOES_HUMANMSNphysical
26496610
RADI_HUMANRDXphysical
26496610
SRRM2_HUMANSRRM2physical
26496610
IBTK_HUMANIBTKphysical
26496610
TBCD7_HUMANTBC1D7physical
26496610
TPPC9_HUMANTRAPPC9physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EZRI_MOUSE

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Related Literatures of Post-Translational Modification

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