KI18B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KI18B_MOUSE
• UniProt AC: Q6PFD6
• Protein Name: Kinesin-like protein KIF18B
• Gene Name: Kif18b
• Organism: Mus musculus (Mouse).
• Sequence Length: 834
• Subcellular Localization: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton . Present predominantly in the nucleus and to a lesser extent in the cytoplasm of interphase cells. During mitosis, found to be closely associated with astral microtubule plus ends emanating from the spindl
• Protein Description: In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity)..
• Protein Sequence: MVMAVEDSVVRVVVRVRPPTPKELESQRRPVIQVVDERMLVFDPEECDGGFPGLKWSGSHNGPKKKGKDLTFVFDRVFGEMATQEDVFQHTTHNILDSFLQGYNCSVFAYGATGAGKTHTMLGREGEPGIMYLTTMELYRRLEARQEEKQFEVLISYLEVYNEQIHDLLEPKGPLTIREDPDKGVVVPGLSFHQPASAEQLLEMLTRGNCSRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQALRVAKMSLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNALADAKGRKSHVPYRDSKLTRLLKDSIGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEIRLTLKSNVISVDHHISQYATICQQLQAEVAFLREKLQMYEAGAQALQQQCSPQPPTLSIPQSLSSSSLQPGPSSQSSTLECHAKNETLQEESLGSDAQGQEIVEESASEQEQCPQDKQCPTQKPEPNLPGSPSPSVQAKPGTGQHSPQKQDADHSKQLALQVLRLAQRQYSLLQAANLLTPDMISEFETLQQLVLEESVDHRAESPRSPALARGDPLAQALCSESKSSGYCGPVTRTMAKQLNGLTHTLGAPLAPDCTSDKTFQKPTKEKKRKLTPEEPGSLPAPNLEMKRQRQSFLPCLRRGSLPKAQPCSEPRTPKRERASSPSPSSRVCPATVIKSRVPLGPSALQNCSTPLALPTRDLNTTFNVSEESPSKPSFQEFVDWEKVSPELNSTDQPFLPSAPVFIFTKGRKPSLPAVTASKKRRTMRPSVSRGRSCIARLHSSTLKKPNRPFTVPEPPLSPHCLDDQRTPKGLTGVTESY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	VVRVRPPTPKELESQ EEEECCCCHHHHHHC	50.07	-
64	Acetylation	SGSHNGPKKKGKDLT CCCCCCCCCCCCCEE	69.39	2393695
65	Acetylation	GSHNGPKKKGKDLTF CCCCCCCCCCCCEEE	70.64	2393703
66	Acetylation	SHNGPKKKGKDLTFV CCCCCCCCCCCEEEE	76.85	2393711
322	S-palmitoylation	KDSIGGNCRTVMIAA HHHCCCCCEEEEEEE	4.34	28526873
431	Phosphorylation	GPSSQSSTLECHAKN CCCCCCCCEEEEECC	31.64	-
484	Phosphorylation	PEPNLPGSPSPSVQA CCCCCCCCCCCCCCC	21.92	25266776
486	Phosphorylation	PNLPGSPSPSVQAKP CCCCCCCCCCCCCCC	31.35	28066266
488	Phosphorylation	LPGSPSPSVQAKPGT CCCCCCCCCCCCCCC	31.06	28066266
499	Phosphorylation	KPGTGQHSPQKQDAD CCCCCCCCCCCCCCC	22.57	25266776
508	Phosphorylation	QKQDADHSKQLALQV CCCCCCHHHHHHHHH	23.73	25266776
558	Phosphorylation	SVDHRAESPRSPALA HHCCCCCCCCCHHHH	25.32	26824392
561	Phosphorylation	HRAESPRSPALARGD CCCCCCCCHHHHCCC	20.22	26824392
628	Phosphorylation	KEKKRKLTPEEPGSL HHHHCCCCCCCCCCC	31.52	22942356
634	Phosphorylation	LTPEEPGSLPAPNLE CCCCCCCCCCCCCHH	41.73	-
648	Phosphorylation	EMKRQRQSFLPCLRR HHHHHHHHHHHHHHH	30.82	-
657	Phosphorylation	LPCLRRGSLPKAQPC HHHHHHCCCCCCCCC	39.42	27149854
669	Phosphorylation	QPCSEPRTPKRERAS CCCCCCCCCCCCCCC	43.83	23384938
676	Phosphorylation	TPKRERASSPSPSSR CCCCCCCCCCCCCCC	49.34	28066266
677	Phosphorylation	PKRERASSPSPSSRV CCCCCCCCCCCCCCC	28.54	25266776
679	Phosphorylation	RERASSPSPSSRVCP CCCCCCCCCCCCCCC	39.09	26643407
681	Phosphorylation	RASSPSPSSRVCPAT CCCCCCCCCCCCCCE	34.80	28066266
682	Phosphorylation	ASSPSPSSRVCPATV CCCCCCCCCCCCCEE	31.92	28066266
688	Phosphorylation	SSRVCPATVIKSRVP CCCCCCCEEEECCCC	14.12	27600695
705	Phosphorylation	PSALQNCSTPLALPT HHHHHCCCCCCCCCC	40.38	28066266
706	Phosphorylation	SALQNCSTPLALPTR HHHHCCCCCCCCCCC	25.23	26643407
718	Phosphorylation	PTRDLNTTFNVSEES CCCCCCCCCCCCCCC	16.49	23984901
722	Phosphorylation	LNTTFNVSEESPSKP CCCCCCCCCCCCCCC	36.43	23984901
725	Phosphorylation	TFNVSEESPSKPSFQ CCCCCCCCCCCCCHH	30.35	23984901
727	Phosphorylation	NVSEESPSKPSFQEF CCCCCCCCCCCHHHH	67.49	23984901
741	Phosphorylation	FVDWEKVSPELNSTD HCCHHHCCCCCCCCC	24.59	26643407
746	Phosphorylation	KVSPELNSTDQPFLP HCCCCCCCCCCCCCC	46.08	26643407
747	Phosphorylation	VSPELNSTDQPFLPS CCCCCCCCCCCCCCC	37.26	26643407
765	Acetylation	FIFTKGRKPSLPAVT EEEECCCCCCCCCCC	47.85	15630767
767	Phosphorylation	FTKGRKPSLPAVTAS EECCCCCCCCCCCCC	50.44	26643407
783	Phosphorylation	KRRTMRPSVSRGRSC CCCCCCCCHHHCCHH	23.51	-
789	Phosphorylation	PSVSRGRSCIARLHS CCHHHCCHHHHHHHH	16.82	28066266
814	Phosphorylation	TVPEPPLSPHCLDDQ CCCCCCCCCCCCCCC	20.55	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KI18B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KI18B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KI18B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IMB1_HUMAN	KPNB1	physical	26496610
E2AK2_HUMAN	EIF2AK2	physical	26496610
VA0D1_HUMAN	ATP6V0D1	physical	26496610
SET1B_HUMAN	SETD1B	physical	26496610
Z512B_HUMAN	ZNF512B	physical	26496610
KI18A_HUMAN	KIF18A	physical	26496610
RAM_HUMAN	FAM103A1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.