CAN6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAN6_MOUSE
• UniProt AC: O35646
• Protein Name: Calpain-6
• Gene Name: Capn6
• Organism: Mus musculus (Mouse).
• Sequence Length: 641
• Subcellular Localization: Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle .
• Protein Description: Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues..
• Protein Sequence: MGPPLKLFKNQKYQELKQECMKDGRLFCDPTFLPENDSLFFNRLLPGKVVWKRPQDISDDPHLIVGNISNHQLIQGRLGNKAMISAFSCLAVQESHWTKAIPNHKDQEWDPRKPEKYAGIFHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIMDFTGTLAEIIDMQKGRYTDLVEEKYKLFGELYKTFTKGGLICCSIESPSQEEQEVETDWGLLKGYTYTMTDIRKLRLGERLVEVFSTEKLYMVRLRNPLGRQEWSGPWSEISEEWQQLTVTDRKNLGLVMSDDGEFWMSLEDFCHNFHKLNVCRNVNNPVFGRKELESVVGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRRFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGSYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEGLEKKYANETVNPYLIIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIIQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Ubiquitination	FNRLLPGKVVWKRPQ HHCCCCCCEEEECCC	31.51	22790023
409	Phosphorylation	LQQKDLRTYRRMGRP EEHHHHHHHHHCCCC	28.77	25338131
440	Phosphorylation	RFRLHHLYIQERAGT CEEEEEEEECCCCCC	9.01	29514104
450	Phosphorylation	ERAGTSTYIDTRTVF CCCCCCCEEEHHHHH	9.14	29514104
453	Phosphorylation	GTSTYIDTRTVFLSK CCCCEEEHHHHHHHH	20.77	-
467	Phosphorylation	KYLKKGSYVLVPTMF HHHHCCCEEEEECCC	13.38	29514104
505	Phosphorylation	TLDMPKMSCWNLARG CCCCCCHHHHHHHCC	23.31	28066266
540	Phosphorylation	ANETVNPYLIIKCGK CCCCCCCEEEEECCH	12.82	29514104
573	Phosphorylation	QAIFYRRTTDIPIII CHHEEEECCCCCEEE	21.59	22871156
574	Phosphorylation	AIFYRRTTDIPIIIQ HHEEEECCCCCEEEE	30.07	22871156
585	Phosphorylation	IIIQVWNSRKFCDQF EEEEEECCHHHHHHH	22.57	22871156
634	Phosphorylation	HISFKVISSDDLTEL EEEEEEECCCCCCCC	30.60	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAN6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAN6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAN6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CAN6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.