SYVC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYVC_MOUSE
• UniProt AC: Q9Z1Q9
• Protein Name: Valine--tRNA ligase
• Gene Name: Vars
• Organism: Mus musculus (Mouse).
• Sequence Length: 1263
• Protein Sequence: MSILYVSPHPDAFPSLRALIAARYGEAGDGPGWGGPHPRICLQPPPSSRTPFPPPRLPALEQGPGGLWVWGAPAVAQLLWPAGLGGPGGSRAAVLVQQWVSYADTELIPAACGATLPALGLRGPGQDPQAALGALGKALNPLEDWLRLHTYLAGDAPTLADLAAVTALLLPFRYVLDPSARRIWGNVTRWFNTCVRQPEFRAVLGEVALYSGARSVTQQPGSEVIAPQKTPAQLKKEAKKREKLEKFQQKQKTQQQPPHGEKKPKPEKKEKRDPGVITYDLPTPPGEKKDVSGAMPDSYSPQYVEAAWYPWWERQGFFKPEYGRPSVSAPNPRGVFMMCIPPPNVTGSLHLGHALTNAIQDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKELTGRTLLPVPGYKEKVEFGVLVSFAYKVQGSDSDEEVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKCVVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEVGQRHRLEAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFITVHDPAVPPGEDPDGRYWVSGRTEAEAREKAAREFGVSPDKISLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIHGVSLQGLYDQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGLCAYTSQGRDINLDVNRILGYRHFCNKLWNATKFALRGLGKGFVPSATSKPEGHESLVDRWIRSRLTEAVRLSNEGFQAYDFPAITTAQYSFWLYELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRTPKAPASLCVTPYPEPSECSWKDPEAEAALELALSITRAVRSLRADYNLTRTRPDCFLEVADEATGALASAVSGYVQALASAGVVAVLALGAPAPQGCAVAVASDRCSIHLQLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKVPLEVQEADEAKLQQTEAELRKVDEAIALFQKML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSILYVSPH ------CCEEEEECC	32.38	-
41	Glutathionylation	GGPHPRICLQPPPSS CCCCCCCCCCCCCCC	2.81	24333276
137	Ubiquitination	AALGALGKALNPLED HHHHHHHHHHCHHHH	51.02	-
174	Phosphorylation	ALLLPFRYVLDPSAR HHHHHHHHHCCHHHH	13.02	18779572
210	Phosphorylation	VLGEVALYSGARSVT HHHHHHHHCCCCCCC	8.70	29899451
211	Phosphorylation	LGEVALYSGARSVTQ HHHHHHHCCCCCCCC	27.16	29899451
215	Phosphorylation	ALYSGARSVTQQPGS HHHCCCCCCCCCCCC	29.05	29899451
222	Phosphorylation	SVTQQPGSEVIAPQK CCCCCCCCCCCCCCC	35.06	29899451
229	Malonylation	SEVIAPQKTPAQLKK CCCCCCCCCHHHHHH	56.25	26320211
230	Phosphorylation	EVIAPQKTPAQLKKE CCCCCCCCHHHHHHH	20.71	26643407
235	Malonylation	QKTPAQLKKEAKKRE CCCHHHHHHHHHHHH	36.17	26320211
246	Malonylation	KKREKLEKFQQKQKT HHHHHHHHHHHHHHH	59.93	26320211
252	Ubiquitination	EKFQQKQKTQQQPPH HHHHHHHHHHCCCCC	56.17	-
253	Phosphorylation	KFQQKQKTQQQPPHG HHHHHHHHHCCCCCC	29.17	18779572
271	Malonylation	PKPEKKEKRDPGVIT CCCCCCCCCCCCCEE	71.61	26320211
283	Phosphorylation	VITYDLPTPPGEKKD CEEEECCCCCCCCCC	49.79	28066266
380	S-nitrosylation	TTLWNPGCDHAGIAT CEECCCCCCCCCEEH	3.50	20925432
380	S-nitrosocysteine	TTLWNPGCDHAGIAT CEECCCCCCCCCEEH	3.50	-
393	Malonylation	ATQVVVEKKLWKERG EHHHHHHHHHHHHHC	41.37	26320211
427	Phosphorylation	AEKGDRIYHQLKKLG HHHCCHHHHHHHHHC	5.61	25367039
431	Ubiquitination	DRIYHQLKKLGSSLD CHHHHHHHHHCCCCC	39.11	-
431	Malonylation	DRIYHQLKKLGSSLD CHHHHHHHHHCCCCC	39.11	26320211
432	Ubiquitination	RIYHQLKKLGSSLDW HHHHHHHHHCCCCCC	67.67	-
432	Malonylation	RIYHQLKKLGSSLDW HHHHHHHHHCCCCCC	67.67	26320211
435	Phosphorylation	HQLKKLGSSLDWDRA HHHHHHCCCCCCCHH	37.86	26643407
436	Phosphorylation	QLKKLGSSLDWDRAC HHHHHCCCCCCCHHH	28.66	26643407
451	Phosphorylation	FTMDPKLSATVTEAF HCCCHHHHEHHHHHH	28.20	24719451
455	Phosphorylation	PKLSATVTEAFVRLH HHHHEHHHHHHHHHH	19.76	24719451
468	Phosphorylation	LHEEGVIYRSTRLVN HHHCCCEEEEEEECE	8.98	22499769
478	S-nitrosocysteine	TRLVNWSCTLNSAIS EEECEEEEECCHHHC	3.66	-
478	S-nitrosylation	TRLVNWSCTLNSAIS EEECEEEEECCHHHC	3.66	20925432
524	Phosphorylation	FAYKVQGSDSDEEVV EEEEECCCCCCCEEE	19.49	28066266
526	Phosphorylation	YKVQGSDSDEEVVVA EEECCCCCCCEEEEE	48.93	25266776
551	Ubiquitination	VAVAVHPKDPRYQHL EEEEECCCCCCHHHH	66.54	-
562	Glutathionylation	YQHLKGKCVVHPFLS HHHHCCCEECCCCCC	5.43	24333276
569	Phosphorylation	CVVHPFLSRSLPIVF EECCCCCCCCCCEEE	21.87	29472430
612	Phosphorylation	RHRLEAISIMDSKGA HHHEEEEEEECCCCC	20.93	29472430
616	Phosphorylation	EAISIMDSKGALINV EEEEEECCCCCEECC	18.66	29899451
637	Malonylation	LPRFEARKAVLAALK CCHHHHHHHHHHHHH	50.31	26320211
644	Acetylation	KAVLAALKERGLFRG HHHHHHHHHCCCCCC	40.41	23954790
644	Malonylation	KAVLAALKERGLFRG HHHHHHHHHCCCCCC	40.41	26320211
653	Ubiquitination	RGLFRGVKDNPMVVP CCCCCCCCCCCEEEE	55.39	-
662	Glutathionylation	NPMVVPLCNRSKDVV CCEEEECCCCCCCCH	3.05	24333276
678	Phosphorylation	PLLRPQWYVRCGEMA HHCCCCEEHHHHHHH	3.47	-
681	S-nitrosylation	RPQWYVRCGEMAQAA CCCEEHHHHHHHHHH	3.74	22178444
681	S-nitrosocysteine	RPQWYVRCGEMAQAA CCCEEHHHHHHHHHH	3.74	-
865	Phosphorylation	HGRKMSKSLGNVIDP CCCCCCCCCCCCCCH	33.91	30352176
880	Phosphorylation	LDVIHGVSLQGLYDQ HHHHHCCCHHHHHHH	21.40	26745281
928	Phosphorylation	LRFGLCAYTSQGRDI HHHCEEHHCCCCCEE	13.11	-
951	Acetylation	GYRHFCNKLWNATKF CHHHHHHHHHHHHHH	56.94	22826441
951	Ubiquitination	GYRHFCNKLWNATKF CHHHHHHHHHHHHHH	56.94	-
951	Malonylation	GYRHFCNKLWNATKF CHHHHHHHHHHHHHH	56.94	26320211
956	Phosphorylation	CNKLWNATKFALRGL HHHHHHHHHHHHHHC	24.39	24759943
957	Acetylation	NKLWNATKFALRGLG HHHHHHHHHHHHHCC	26.65	22826441
965	Malonylation	FALRGLGKGFVPSAT HHHHHCCCCCCCCCC	54.97	26320211
974	Acetylation	FVPSATSKPEGHESL CCCCCCCCCCCCHHH	42.61	23236377
974	Malonylation	FVPSATSKPEGHESL CCCCCCCCCCCCHHH	42.61	26320211
1184	S-nitrosocysteine	VAVASDRCSIHLQLQ EEEECCCEEEEEECC	5.56	-
1184	S-nitrosylation	VAVASDRCSIHLQLQ EEEECCCEEEEEECC	5.56	20925432
1202	Malonylation	DPARELGKLQAKRSE CHHHHHHHHHHHHHH	50.48	26320211
1208	Phosphorylation	GKLQAKRSEAQRQAQ HHHHHHHHHHHHHHH	36.26	29514104
1224	Phosphorylation	LQERRAASSYSAKVP HHHHHHHHHCCCCCC	28.91	27149854
1225	Phosphorylation	QERRAASSYSAKVPL HHHHHHHHCCCCCCC	20.55	30635358
1227	Phosphorylation	RRAASSYSAKVPLEV HHHHHHCCCCCCCCC	24.46	30635358
1229	Malonylation	AASSYSAKVPLEVQE HHHHCCCCCCCCCHH	38.14	26320211
1241	Acetylation	VQEADEAKLQQTEAE CHHHHHHHHHHHHHH	44.79	23236377

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYVC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYVC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYVC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SYVC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.