dbPTM

PIGR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PIGR_MOUSE
UniProt AC	O70570
Protein Name	Polymeric immunoglobulin receptor
Gene Name	Pigr
Organism	Mus musculus (Mouse).
Sequence Length	771
Subcellular Localization	Cell membrane Single-pass type I membrane protein. Secretory component: Secreted.
Protein Description	This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity)..
Protein Sequence	MRLYLFTLLVTVFSGVSTKSPIFGPQEVSSIEGDSVSITCYYPDTSVNRHTRKYWCRQGASGMCTTLISSNGYLSKEYSGRANLINFPENNTFVINIEQLTQDDTGSYKCGLGTSNRGLSFDVSLEVSQVPELPSDTHVYTKDIGRNVTIECPFKRENAPSKKSLCKKTNQSCELVIDSTEKVNPSYIGRAKLFMKGTDLTVFYVNISHLTHNDAGLYICQAGEGPSADKKNVDLQVLAPEPELLYKDLRSSVTFECDLGREVANEAKYLCRMNKETCDVIINTLGKRDPDFEGRILITPKDDNGRFSVLITGLRKEDAGHYQCGAHSSGLPQEGWPIQTWQLFVNEESTIPNRRSVVKGVTGGSVAIACPYNPKESSSLKYWCRWEGDGNGHCPVLVGTQAQVQEEYEGRLALFDQPGNGTYTVILNQLTTEDAGFYWCLTNGDSRWRTTIELQVAEATREPNLEVTPQNATAVLGETFTVSCHYPCKFYSQEKYWCKWSNKGCHILPSHDEGARQSSVSCDQSSQLVSMTLNPVSKEDEGWYWCGVKQGQTYGETTAIYIAVEERTRGSSHVNPTDANARAKVALEEEVVDSSISEKENKAIPNPGPFANEREIQNVGDQAQENRASGDAGSADGQSRSSSSKVLFSTLVPLGLVLAVGAIAVWVARVRHRKNVDRMSISSYRTDISMADFKNSRDLGGNDNMGASPDTQQTVIEGKDEIVTTTECTAEPEESKKAKRSSKEEADMAYSAFLLQSSTIAAQVHDGPQEA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	N-linked_Glycosylation	NLINFPENNTFVINI CEEECCCCCEEEEEE	53.75	-
147	N-linked_Glycosylation	YTKDIGRNVTIECPF EECCCCCCEEEECCC	30.03	-
170	N-linked_Glycosylation	KSLCKKTNQSCELVI HHHCHHCCCCCEEEE	40.42	-
206	N-linked_Glycosylation	DLTVFYVNISHLTHN CEEEEEEEHHHCCCC	20.75	-
420	N-linked_Glycosylation	ALFDQPGNGTYTVIL EEECCCCCCEEEEEE	46.44	-
471	N-linked_Glycosylation	NLEVTPQNATAVLGE CCEECCCCCEEEECC	40.23	-
594	Phosphorylation	LEEEVVDSSISEKEN EEHHHHCCCCCHHHH	20.26	30352176
595	Phosphorylation	EEEVVDSSISEKENK EHHHHCCCCCHHHHC	26.18	30352176
680	Phosphorylation	RKNVDRMSISSYRTD HCCCCCCEEEECCCC	21.88	26487105
682	Phosphorylation	NVDRMSISSYRTDIS CCCCCEEEECCCCCC	17.63	22324799
683	Phosphorylation	VDRMSISSYRTDISM CCCCEEEECCCCCCH	19.57	22324799
684	Phosphorylation	DRMSISSYRTDISMA CCCEEEECCCCCCHH	15.67	22324799
686	Phosphorylation	MSISSYRTDISMADF CEEEECCCCCCHHHH	29.47	22324799
689	Phosphorylation	SSYRTDISMADFKNS EECCCCCCHHHHCCC	15.66	25521595
690	Oxidation	SYRTDISMADFKNSR ECCCCCCHHHHCCCC	4.19	17242355
694	Ubiquitination	DISMADFKNSRDLGG CCCHHHHCCCCCCCC	55.34	22790023
696	Phosphorylation	SMADFKNSRDLGGND CHHHHCCCCCCCCCC	27.97	29472430
741	Phosphorylation	ESKKAKRSSKEEADM HHHHHHHCCHHHHHH	45.09	25521595
742	Phosphorylation	SKKAKRSSKEEADMA HHHHHHCCHHHHHHH	48.39	19060867
748	Oxidation	SSKEEADMAYSAFLL CCHHHHHHHHHHHHH	4.93	17242355
750	Phosphorylation	KEEADMAYSAFLLQS HHHHHHHHHHHHHHH	8.22	23984901
751	Phosphorylation	EEADMAYSAFLLQSS HHHHHHHHHHHHHHC	11.73	19060867
757	Phosphorylation	YSAFLLQSSTIAAQV HHHHHHHHCCEEEEE	29.44	23984901
758	Phosphorylation	SAFLLQSSTIAAQVH HHHHHHHCCEEEEEC	15.75	23140645
759	Phosphorylation	AFLLQSSTIAAQVHD HHHHHHCCEEEEECC	21.63	23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PIGR_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PIGR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PIGR_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PIGR_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PIGR_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-741, AND MASSSPECTROMETRY.	17242355 [Abstract]