PSPC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSPC1_MOUSE
• UniProt AC: Q8R326
• Protein Name: Paraspeckle component 1
• Gene Name: Pspc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 523
• Subcellular Localization: Nucleus, nucleolus. In punctate subnuclear structures localized adjacent to nuclear splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycle between paraspeckl
• Protein Description: Together with NONO, required for the formation of nuclear paraspeckles. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway..
• Protein Sequence: MMLRGNLKQVRIEKNPARLRALESAAGESEPVAAAAMALTLAGEQAPPPAPSEEHPDEELGFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGGFKPNYMENREQEMRMGDMGPRGAINMGDAFSPAPAGTQGPPPMMGMNMNNRGTIPGPPMGPGPAMGPEGAANMGTPMIPDNGAVHNDRFPQGPPSQMGSPMGNRTGSETPQAPMSGVGPVSGGPGGFGRGSQGGNFEGPNKRRRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMLRGNLK -------CCCCCCCE	5.28	-
98	Acetylation	DITEEDFKRLFERYG CCCHHHHHHHHHHHC	61.59	10282015
163	Phosphorylation	ALTVKNLSPVVSNEL EEEECCCCHHCCHHH	25.66	25293948
167	Phosphorylation	KNLSPVVSNELLEQA CCCCHHCCHHHHHHH	25.48	25293948
176	Phosphorylation	ELLEQAFSQFGPVEK HHHHHHHHHHCCCCE	27.84	25293948
251	Phosphorylation	PEKLMQKTQQYHKER CHHHHHHHHHHHHHH	12.19	22817900
269	Phosphorylation	PRFAQPGTFEFEYAS CCCCCCCEEEEEHHH	27.03	30635358
274	Phosphorylation	PGTFEFEYASRWKAL CCEEEEEHHHHHHHH	18.39	30635358
276	Phosphorylation	TFEFEYASRWKALDE EEEEEHHHHHHHHHH	37.46	30635358
286	Ubiquitination	KALDEMEKQQREQVD HHHHHHHHHHHHHHH	50.88	-
409	Phosphorylation	INMGDAFSPAPAGTQ CCCCCCCCCCCCCCC	23.13	26239621
415	Phosphorylation	FSPAPAGTQGPPPMM CCCCCCCCCCCCCCC	32.24	26239621
453	Phosphorylation	EGAANMGTPMIPDNG CCHHCCCCCCCCCCC	10.02	23140645
473	Phosphorylation	RFPQGPPSQMGSPMG CCCCCCHHHCCCCCC	35.61	21149613
477	Phosphorylation	GPPSQMGSPMGNRTG CCHHHCCCCCCCCCC	13.33	25521595
483	Phosphorylation	GSPMGNRTGSETPQA CCCCCCCCCCCCCCC	49.40	22006019
487	Phosphorylation	GNRTGSETPQAPMSG CCCCCCCCCCCCCCC	23.54	-
507	Methylation	GGPGGFGRGSQGGNF CCCCCCCCCCCCCCC	39.05	24129315
507	Dimethylation	GGPGGFGRGSQGGNF CCCCCCCCCCCCCCC	39.05	-
509	Phosphorylation	PGGFGRGSQGGNFEG CCCCCCCCCCCCCCC	25.04	-
520	Methylation	NFEGPNKRRRY---- CCCCCCCCCCC----	34.64	18958517
520	Dimethylation	NFEGPNKRRRY---- CCCCCCCCCCC----	34.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSPC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSPC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSPC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.