AMRP_MOUSE - dbPTM
AMRP_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AMRP_MOUSE
UniProt AC P55302
Protein Name Alpha-2-macroglobulin receptor-associated protein
Gene Name Lrpap1
Organism Mus musculus (Mouse).
Sequence Length 360
Subcellular Localization Rough endoplasmic reticulum lumen . Endoplasmic reticulum-Golgi intermediate compartment lumen . Golgi apparatus, cis-Golgi network . Golgi apparatus lumen . Endosome lumen . Cell surface . May be associated with receptors at the cell surface.
Protein Description Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway..
Protein Sequence MAPRRERVSTLPRLQLLVLLLLPLMLVPQPIAGHGGKYSREKNEPEMAAKRESGEEFRMEKLNQLWEKAKRLHLSPVRLAELHSDLKIQERDELNWKKLKVEGLDKDGEKEAKLIHNLNVILARYGLDGRKDAQMVHSNALNEDTQDELGDPRLEKLWHKAKTSGKFSSEELDKLWREFLHYKEKIQEYNVLLDTLSRAEEGYENLLSPSDMAHIKSDTLISKHSELKDRLRSINQGLDRLRKVSHQGYGSTTEFEEPRVIDLWDLAQSANFTEKELESFREELKHFEAKIEKHNHYQKQLEISHQKLKHVESIGDPEHISRNKEKYVLLEEKTKELGYKVKKHLQDLSSRVSRARHNEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
53PhosphorylationEMAAKRESGEEFRME
HHHHHHHHHHHHHHH		56.3825521595
84PhosphorylationVRLAELHSDLKIQER
HHHHHHHCCCCCCCC		58.2128066266
131UbiquitinationRYGLDGRKDAQMVHS
HHCCCCCHHHHHHHH		64.05-
138PhosphorylationKDAQMVHSNALNEDT
HHHHHHHHCCCCCCC		16.6422817900
145PhosphorylationSNALNEDTQDELGDP
HCCCCCCCCHHHCCH		31.5726525534
169PhosphorylationKTSGKFSSEELDKLW
HHCCCCCHHHHHHHH		37.9222817900
185UbiquitinationEFLHYKEKIQEYNVL
HHHHHHHHHHHHHHH		45.60-
203PhosphorylationLSRAEEGYENLLSPS
HHHHHHHHHHCCCHH		12.6228066266
208PhosphorylationEGYENLLSPSDMAHI
HHHHHCCCHHHHHHH		26.0627742792
210PhosphorylationYENLLSPSDMAHIKS
HHHCCCHHHHHHHCC		36.3227742792
223AcetylationKSDTLISKHSELKDR
CCCCHHHCCHHHHHH		44.1222826441
225PhosphorylationDTLISKHSELKDRLR
CCHHHCCHHHHHHHH		48.6528464351
233PhosphorylationELKDRLRSINQGLDR
HHHHHHHHHHHHHHH		30.4027742792
245PhosphorylationLDRLRKVSHQGYGST
HHHHHHHHCCCCCCC		17.0926525534
249PhosphorylationRKVSHQGYGSTTEFE
HHHHCCCCCCCCCCC		11.0027742792
251PhosphorylationVSHQGYGSTTEFEEP
HHCCCCCCCCCCCCC		24.5426525534
252PhosphorylationSHQGYGSTTEFEEPR
HCCCCCCCCCCCCCE		26.4426525534
253PhosphorylationHQGYGSTTEFEEPRV
CCCCCCCCCCCCCEE		40.1326525534
269O-linked_GlycosylationDLWDLAQSANFTEKE
EHHHHHHHCCCCHHH		21.4130059200
271N-linked_GlycosylationWDLAQSANFTEKELE
HHHHHHCCCCHHHHH		50.01-
290AcetylationELKHFEAKIEKHNHY
HHHHHHHHHHHCCHH		44.1722826441
309AcetylationEISHQKLKHVESIGD
HHHHHHHHHHHHHCC		53.2722826441
313PhosphorylationQKLKHVESIGDPEHI
HHHHHHHHHCCHHHH		30.6826824392
326AcetylationHISRNKEKYVLLEEK
HHCCCHHHEEEEHHH		42.1221728379
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AMRP_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AMRP_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AMRP_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AMRP_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AMRP_MOUSE

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Related Literatures of Post-Translational Modification

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