NDC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDC1_MOUSE
• UniProt AC: Q8VCB1
• Protein Name: Nucleoporin NDC1
• Gene Name: Ndc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 673
• Subcellular Localization: Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Central core structure of the nuclear pore complex..
• Protein Description: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity)..
• Protein Sequence: MATAASGPCAGGSPRDILWRVLGWRIVTSIVWSVVLLPVCITAFIVLSSINLFHPIQWLSDSCNDFYSSQVIFHLLLLAVVIIIISIFNVEFYTVVPSISGSRLALIARILHPQQLTHSFIHAAMGMAVAWCAAIMTKGQYSSLVVPCTGTESLDSPAAQTCLNEYHLFFLLSGAFMGYSYSLLYFINNMNYLPFPIIQQYKFLRFRRSLLLLVKHSCVESLFMVRNFCIVYYFFGHIPKAWISTALDLHTDEQAHRPLDTIGGLLNVSLLYHVWLCGVFLLVTWYSSWILFKIYATEAHVFPVQPPFAEASDECLPKVLNSNPPRIVKYLALQDLMLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNDMTQKLVLYQEAAATNGRMYSSYSVEPKKLSSAEETAFQTPKPSQTPSVPPLVKTSLFSPKLSTPNVSSPFGTPFGSSVVNRMAGILDVNPFSGSPQSPQLIRRGPRLWTHTSDQQVSAISNPSPCASVTAEGKTVRQPSVIYSWIQNKREQIKNFLSKRVLIMYFFSKHPEASIQAVFSDAQMHIWALEGLSHLVAASFTEDRFGVVQTTLPAILHTLLTLQEAVDKYFKLPHASSKPPRASGSLVDTSYKTLRFAFRASLKTAIYRITTTFGEHLNAVQASAEHQKRLQQFLEFKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
330	Phosphorylation	NPPRIVKYLALQDLM CCHHHHHHHHHHHHH	6.06	25293948
340	Phosphorylation	LQDLMLLSQYSPSRR HHHHHHHHCCCHHHH	24.10	25293948
342	Phosphorylation	DLMLLSQYSPSRRQE HHHHHHCCCHHHHHE	21.12	25293948
343	Phosphorylation	LMLLSQYSPSRRQEV HHHHHCCCHHHHHEE	14.57	25293948
345	Phosphorylation	LLSQYSPSRRQEVFS HHHCCCHHHHHEEEE	33.87	25293948
380	Ubiquitination	LLNDMTQKLVLYQEA HHCHHHHHHHHHHHH	31.25	-
396	Phosphorylation	ATNGRMYSSYSVEPK HHCCCCEEEEECCCC	17.29	26643407
397	Phosphorylation	TNGRMYSSYSVEPKK HCCCCEEEEECCCCC	12.16	25266776
398	Phosphorylation	NGRMYSSYSVEPKKL CCCCEEEEECCCCCC	15.70	26643407
399	Phosphorylation	GRMYSSYSVEPKKLS CCCEEEEECCCCCCC	23.19	26643407
406	Phosphorylation	SVEPKKLSSAEETAF ECCCCCCCCCHHHHC	36.06	28066266
407	Phosphorylation	VEPKKLSSAEETAFQ CCCCCCCCCHHHHCC	50.57	28066266
411	Phosphorylation	KLSSAEETAFQTPKP CCCCCHHHHCCCCCC	25.03	28066266
415	Phosphorylation	AEETAFQTPKPSQTP CHHHHCCCCCCCCCC	27.16	29514104
419	Phosphorylation	AFQTPKPSQTPSVPP HCCCCCCCCCCCCCC	53.46	29472430
421	Phosphorylation	QTPKPSQTPSVPPLV CCCCCCCCCCCCCCE	23.13	29472430
423	Phosphorylation	PKPSQTPSVPPLVKT CCCCCCCCCCCCEEC	51.12	29472430
429	Ubiquitination	PSVPPLVKTSLFSPK CCCCCCEECCCCCCC	39.83	-
434	Phosphorylation	LVKTSLFSPKLSTPN CEECCCCCCCCCCCC	26.81	22942356
436	Ubiquitination	KTSLFSPKLSTPNVS ECCCCCCCCCCCCCC	54.60	-
438	Phosphorylation	SLFSPKLSTPNVSSP CCCCCCCCCCCCCCC	48.20	25619855
439	Phosphorylation	LFSPKLSTPNVSSPF CCCCCCCCCCCCCCC	29.35	25619855
443	Phosphorylation	KLSTPNVSSPFGTPF CCCCCCCCCCCCCCC	38.64	25619855
444	Phosphorylation	LSTPNVSSPFGTPFG CCCCCCCCCCCCCCC	21.69	25619855
448	Phosphorylation	NVSSPFGTPFGSSVV CCCCCCCCCCCHHHH	18.80	25619855
452	Phosphorylation	PFGTPFGSSVVNRMA CCCCCCCHHHHHHHC	21.97	25619855
453	Phosphorylation	FGTPFGSSVVNRMAG CCCCCCHHHHHHHCC	30.39	25619855
468	Phosphorylation	ILDVNPFSGSPQSPQ CCCCCCCCCCCCCHH	39.35	25159016
470	Phosphorylation	DVNPFSGSPQSPQLI CCCCCCCCCCCHHHH	20.68	26824392
473	Phosphorylation	PFSGSPQSPQLIRRG CCCCCCCCHHHHHCC	20.28	27087446
493	Phosphorylation	HTSDQQVSAISNPSP ECCCCCCHHCCCCCC	18.62	-
496	Phosphorylation	DQQVSAISNPSPCAS CCCCHHCCCCCCCCE	42.26	25619855
499	Phosphorylation	VSAISNPSPCASVTA CHHCCCCCCCCEEEE	36.54	25619855
503	Phosphorylation	SNPSPCASVTAEGKT CCCCCCCEEEECCCC	27.07	25619855
505	Phosphorylation	PSPCASVTAEGKTVR CCCCCEEEECCCCCC	19.25	25619855
618	Phosphorylation	SSKPPRASGSLVDTS CCCCCCCCCCCCCCC	30.14	-
626	Phosphorylation	GSLVDTSYKTLRFAF CCCCCCCHHHHHHHH	15.30	28059163
628	Phosphorylation	LVDTSYKTLRFAFRA CCCCCHHHHHHHHHH	18.22	22942356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDC1_HUMAN	NDC1	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.