AQR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AQR_MOUSE
• UniProt AC: Q8CFQ3
• Protein Name: RNA helicase aquarius
• Gene Name: Aqr
• Organism: Mus musculus (Mouse).
• Sequence Length: 1481
• Subcellular Localization: Nucleus . Nucleus, nucleoplasm . Localizes to speckle-like regions of the nucleoplasm.
• Protein Description: Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro)..
• Protein Sequence: MAAPAQPKKIVAPTVSQINAEFVTQLACKYWAPHIKKKSPFDIKVIEEIYEKEIVKSRFAIRKIMLLEFSQYLENYLWMNYSPEVSSKAYLMSICCMVNEKFRENVPAWETFKKKPDHFPFFFKCILKAALAETDGEFSLHEQTLLLLFLDHCFNSLEVDLIRSQVQQLISLPMWMGLQPARLELELKKTPKLRKFWNLIKKNDEKMDPEAREQAYQERRFLSRLIQKFISVLKSIPLSEPVTMDKVHYCERFIELMIDLEALLPTRRWFNTILDDSHLLVHCYLSSLVHREEDGHLFSQLLDMLKFYTGFEINDQTGNALTENEMTTIHYDRITSLQRAAFAHFPELYDFALSNVAEVDARDSLVKFFGPLSSNTLHQVASYLCLLPTLPKNEDTTFDKEFLLELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWARMAQPIVAFTVVEVAKPNIGENWPTRVRADVTINLNVRDHIKDEWEGLRKHDVCFLITVRPTKPYGTKFDRRRPFIEQVGLVYVRGCEIQGMLDDKGRVIEDGPEPRPNLRGESRTFRVFLDPNQYQQDMTNTIQNGAEDVYDTFNVIMRRKPKENNFKAVLETIRNLMNTDCVVPDWLHDIILGYGDPSSAHYSKMPNQIATLDFNDTFLSIEHLKASFPGHNVKVTVSDPALQIPPFRITFPVRSGKGKKRKDADGEEDDTEEAKTLIVEPHVIPNRGPYPYNQPKRNTIQFTHTQIEAIRAGMQPGLTMVVGPPGTGKTDVAVQIISNIYHNFPEQRTLIVTHSNQALNQLFEKIMALDIDERHLLRLGHGEEELETEKDFSRYGRVNYVLARRIELLEEVKRLQKSLGVPGDASYTCETAGYFFLYQVMSRWEEYMSRVKNSGTACPDAAPDAAQVATFFPFHEYFANAPQPIFKGRSYEEDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKYLLVKEAKIIAMTCTHAALKRHDLVKLGFKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMIGDHHQLPPVIKNMAFQKYSNMEQSLFTRFVRVGVPTVDLDAQGRARASLCNLYNWRYKNLGNLPHVQLLPEFSTANAGLLYDFQLINVEDFQGVGESEPNPYFYQNLGEAEYVVALFMYMCLLGYPADKISILTTYNGQKHLIRDIINRRCGNNPLIGRPNKVTTVDRFQGQQNDYILLSLVRTRAVGHLRDVRRLVVAMSRARLGLYIFARVSLFQNCFELTPAFSQLTARPLHLHIIPTEPFPTSRKNGERPPHEVQVIKNMPQMANFVYNMYMHLIQTTHHYHQTFLQLPPAMVEEGEEGQSQETEMEAEEETVSAQGNLTPSPADASLSQETPAAQPDCSSQTEDTSAPCDIATAAEPVSAAAEAATPQDAESVPTETE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	KIVAPTVSQINAEFV CEECCCHHHHCHHHH	28.02	27600695
111	Phosphorylation	ENVPAWETFKKKPDH HCCCHHHHHCCCCCC	30.01	25177544
216	Phosphorylation	PEAREQAYQERRFLS HHHHHHHHHHHHHHH	15.59	-
223	Phosphorylation	YQERRFLSRLIQKFI HHHHHHHHHHHHHHH	23.48	-
497	Phosphorylation	SRMKPWQSEYGGVVF HHCCCCHHHCCCEEE	28.99	25367039
499	Phosphorylation	MKPWQSEYGGVVFGG CCCCHHHCCCEEECH	25.15	25367039
736	Phosphorylation	PGHNVKVTVSDPALQ CCCCEEEEECCHHHC	14.47	25159016
738	Phosphorylation	HNVKVTVSDPALQIP CCEEEEECCHHHCCC	28.63	25159016
1055	Acetylation	LKRHDLVKLGFKYDN HHHCCHHHHCCCCCC	50.63	-
1115	Ubiquitination	IKNMAFQKYSNMEQS HHHHHHHHHCCHHHH	44.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AQR_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AQR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AQR_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AQR_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.