LZTS2_MOUSE - dbPTM
LZTS2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LZTS2_MOUSE
UniProt AC Q91YU6
Protein Name Leucine zipper putative tumor suppressor 2 {ECO:0000255|HAMAP-Rule:MF_03026}
Gene Name Lzts2
Organism Mus musculus (Mouse).
Sequence Length 671
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
Protein Description Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin..
Protein Sequence MAIVHTLPVPLEPARETATAPKTPAMGSVSSLISGRPCPGGPAPQRHHGVPGPTFFRQQDGLLPGGYEAQEPLCPAVPPRKAVPGNSFTYVNEDFRTESPPSPSSDVEDPREHQAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPGFLGPRAAGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLALSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTTNSPGGHLPSHGPGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGARASPGSSSGGDRSPPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSMDESEATVCQAFGARQRRWPRERGEDCAAQAQQATQRVQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATFEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAREQELEACSQELQRYRQEAERLREKAGHLDAEASGLRDPPVPPATTDPFLLAESDEAKVQRAAAGAGGSLRAQVERLRQELQREQRRGDEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAESAPCICLEEITATEI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
90PhosphorylationVPGNSFTYVNEDFRT
CCCCCCEEECCCCCC		10.16-
97PhosphorylationYVNEDFRTESPPSPS
EECCCCCCCCCCCCC		40.5925619855
99PhosphorylationNEDFRTESPPSPSSD
CCCCCCCCCCCCCCC		41.3125619855
102PhosphorylationFRTESPPSPSSDVED
CCCCCCCCCCCCCCC		40.5825619855
104PhosphorylationTESPPSPSSDVEDPR
CCCCCCCCCCCCCHH		43.4327841257
105PhosphorylationESPPSPSSDVEDPRE
CCCCCCCCCCCCHHH		49.4027841257
224PhosphorylationLSDSGRNSLSSLPTY
CCCCCCCCHHCCCCC		28.4121743459
226PhosphorylationDSGRNSLSSLPTYST
CCCCCCHHCCCCCCC		29.6521743459
227PhosphorylationSGRNSLSSLPTYSTG
CCCCCHHCCCCCCCC		43.6026160508
230PhosphorylationNSLSSLPTYSTGGAE
CCHHCCCCCCCCCCC		35.0826160508
231PhosphorylationSLSSLPTYSTGGAEP
CHHCCCCCCCCCCCC		11.4226160508
232PhosphorylationLSSLPTYSTGGAEPT
HHCCCCCCCCCCCCC		24.0526160508
233PhosphorylationSSLPTYSTGGAEPTT
HCCCCCCCCCCCCCC		29.2626160508
239PhosphorylationSTGGAEPTTNSPGGH
CCCCCCCCCCCCCCC		30.0726160508
240PhosphorylationTGGAEPTTNSPGGHL
CCCCCCCCCCCCCCC		44.4026160508
242PhosphorylationGAEPTTNSPGGHLPS
CCCCCCCCCCCCCCC		23.8821659605
249PhosphorylationSPGGHLPSHGPGRGA
CCCCCCCCCCCCCCC		47.6526160508
269PhosphorylationRGVPTGPSHSDSGRS
CCCCCCCCCCCCCCC		36.6525338131
271PhosphorylationVPTGPSHSDSGRSSS
CCCCCCCCCCCCCCC		37.5023684622
273PhosphorylationTGPSHSDSGRSSSSK
CCCCCCCCCCCCCCC		38.8429899451
277PhosphorylationHSDSGRSSSSKSTGS
CCCCCCCCCCCCCCC		36.9523684622
278PhosphorylationSDSGRSSSSKSTGSL
CCCCCCCCCCCCCCC		42.9323684622
279PhosphorylationDSGRSSSSKSTGSLG
CCCCCCCCCCCCCCC		32.3525338131
296PhosphorylationVAGGLLGSGARASPG
ECCCCCCCCCCCCCC		29.2827180971
301PhosphorylationLGSGARASPGSSSGG
CCCCCCCCCCCCCCC		25.0026643407
304PhosphorylationGARASPGSSSGGDRS
CCCCCCCCCCCCCCC		25.3926643407
305PhosphorylationARASPGSSSGGDRSP
CCCCCCCCCCCCCCC		38.6326643407
306PhosphorylationRASPGSSSGGDRSPP
CCCCCCCCCCCCCCC		48.7925293948
311PhosphorylationSSSGGDRSPPPPPPP
CCCCCCCCCCCCCCC		46.6421659605
321PhosphorylationPPPPPPPSDEALLHC
CCCCCCCCHHHHHHH		54.5827717184
347PhosphorylationELQQLRDSMDESEAT
HHHHHHHCCCHHHHH		23.0026643407
382PhosphorylationAAQAQQATQRVQRAQ
HHHHHHHHHHHHHHH		16.7529899451
460SuccinylationSLLKQQLKESQAELV
HHHHHHHHHHHHHHH		51.4824315375
572PhosphorylationAAAGAGGSLRAQVER
HHCCCCHHHHHHHHH		17.4827087446
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LZTS2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LZTS2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LZTS2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LZTS2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LZTS2_MOUSE

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Related Literatures of Post-Translational Modification

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