dbPTM

NOP14_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NOP14_MOUSE
UniProt AC	Q8R3N1
Protein Name	Nucleolar protein 14
Gene Name	Nop14
Organism	Mus musculus (Mouse).
Sequence Length	860
Subcellular Localization	Nucleus, nucleolus.
Protein Description	Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity)..
Protein Sequence	MGKAKRTGARRQVHKAPAGASGGPAKTNPNPFEVKVNRQKFQILGRKTRHDVGLPGVSRARAIRKRTQTLLKEYKERNKSNVFADKRFGEYNSNISPEEKMMKRFALEQQRYHEKKNIYNLNEDEELTHYGQSLADIEKHNDIVDSDSDTEDRGALSAELTASHFGGGVHKNSSQKEGEDGDKPKTRKELIEELIAKSKQEKRERQAQREDALELTEKLDQDWKEIQILMSRKPKKSEDKEKKEKPQPDEYDMMVRELGFEMKAQPSNRMKTEEELAKEEQERLKKLEAERLRRMLGKDEHENKKKPKHTSADDLNDGFILDKDDRRLLSYKDGKMNIEDVQEEQSKEADGQENDQKEGEDDSEEEDESHEDSEESEDPDSHSDLESNIESEEENETPKKEQRQTPGGKLPKDDQKAQKAVAAELPYVFAAPESFEELKFLLSGRSMEEQLLVVERIQKCNHPSLAVGNKAKLEKLFGFLLQYIGDLATDSTPDLKTIDKLVVHLYSLCQMFPESASDSIRFVLRDAMHEMEEMIETKGRAAFPGLDVLIYLKITGLLFPTSDFWHPVVTPALLCMSQMLTKCPVMSLQDVIKGLFVCCLFLEYVSLSRRFIPELFNFLLGILYIATPNTKSQGSTLVHPFRALGKNSELLVVSDKADVTTWQRGSLPLHWANRLSTLTATEANHTRLSCVASCLSLMKHCVLMYQALPSFHAIFRPHQALLSKHLADCSLPQELQELAQSILSAMEGQKQHCRPLVCEKSKPVPLKQFTPRLVKVLEFGRKQGSSKEEQERKRLIHKHKREFKGAVREIRKDNQFLARMQLSEIMERDAERKRKVKQLFNSLATQEGEWKALKRKKFKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	DVGLPGVSRARAIRK CCCCCCHHHHHHHHH	26.57	-
91	Phosphorylation	ADKRFGEYNSNISPE CCHHHHCCCCCCCHH	25.03	25619855
93	Phosphorylation	KRFGEYNSNISPEEK HHHHCCCCCCCHHHH	34.34	25619855
96	Phosphorylation	GEYNSNISPEEKMMK HCCCCCCCHHHHHHH	30.43	26824392
119	Phosphorylation	YHEKKNIYNLNEDEE HHHHCCCCCCCCCHH	24.00	25367039
128	Phosphorylation	LNEDEELTHYGQSLA CCCCHHHHHHHHHHH	19.14	25367039
130	Phosphorylation	EDEELTHYGQSLADI CCHHHHHHHHHHHHH	16.18	25367039
133	Phosphorylation	ELTHYGQSLADIEKH HHHHHHHHHHHHHHH	22.59	25367039
146	Phosphorylation	KHNDIVDSDSDTEDR HHCCCCCCCCCCCCH	28.28	25521595
148	Phosphorylation	NDIVDSDSDTEDRGA CCCCCCCCCCCCHHH	50.84	25521595
150	Phosphorylation	IVDSDSDTEDRGALS CCCCCCCCCCHHHHH	43.68	25521595
157	Phosphorylation	TEDRGALSAELTASH CCCHHHHHHHHHHHH	21.11	22324799
161	Phosphorylation	GALSAELTASHFGGG HHHHHHHHHHHHCCC	20.02	25159016
163	Phosphorylation	LSAELTASHFGGGVH HHHHHHHHHHCCCCC	17.70	25159016
198	Phosphorylation	IEELIAKSKQEKRER HHHHHHHHHHHHHHH	30.46	20139300
310	Phosphorylation	NKKKPKHTSADDLND CCCCCCCCCHHHCCC	31.56	28066266
311	Phosphorylation	KKKPKHTSADDLNDG CCCCCCCCHHHCCCC	29.44	22817900
330	Phosphorylation	KDDRRLLSYKDGKMN CCCCEEECCCCCCCC	34.43	29514104
346	Phosphorylation	EDVQEEQSKEADGQE HHHHHHHHHHCCCCC	35.42	27566939
405	Phosphorylation	PKKEQRQTPGGKLPK CCHHHCCCCCCCCCC	26.53	25338131
537	Phosphorylation	EMEEMIETKGRAAFP HHHHHHHHHCCCCCC	28.07	26824392
775	Acetylation	QFTPRLVKVLEFGRK HCCHHHHHHHHHHHH	45.77	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NOP14_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NOP14_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NOP14_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NOP14_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NOP14_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146 AND SER-148, ANDMASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146 AND SER-148, ANDMASS SPECTROMETRY.	17242355 [Abstract]