ATAD2_MOUSE - dbPTM
ATAD2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATAD2_MOUSE
UniProt AC Q8CDM1
Protein Name ATPase family AAA domain-containing protein 2
Gene Name Atad2
Organism Mus musculus (Mouse).
Sequence Length 1040
Subcellular Localization Nucleus.
Protein Description May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation (By similarity)..
Protein Sequence MSLLKMRRHAIHSSDSTSSSSSEDDCFERRTKRNRNRAINRCLPLNFRKDEIRGIYKDRMKIGASLADVDPMQLDTSVRFDSVGGLSSHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSRGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPAIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPDKNARKEILKIHTRDWNPKPVDMFLEELAEHCVGYCGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSITISAKDFEAALQKIRPASQRAVTSPGQALSAIVKPLLQNTVHRILDALQKVFPHVEVGTNKSLNSDVSCPFLESDLAYSDDDTPSVYENGLSQKENLNFLHLNRNACYQPMSFRPRLLIVGEPGFGQSSHLAPAVIHALEKFTVYTLDIPVLFGISTTSPEEACSQMIREAKRTAPSIVYVPHIHLWWEIVGPTLKATFTTLLQTIPSFAPVLLLATSEKPYSALPEEVQELFTHDYGEIFNVQLPDKEERTKFFEDLILKQASKPPVSQKKAVLQALEVLPVAPPPEPRPLTAEEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDYLKDIDLICSNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSPPVGDKKPDQEQNEKLKVPCTPVACSTPAQLKRKFHKKSKWHVGTKIKRRKISQAKDNSLNAMNSSSRSDTEDSQHTHAEHTEPGNTDESSVEESDKQNRLESNIDLKNNSSSSNIENELEEPKETTEGTELRKDRIVCRGDASASQVTDIPEDSESKEMDFLRMTLARGSQVEQQELISMEQALAILSQPTPSLVLDHKQLTNILKTVVKKSQKYNIFQLENLYAVISQCIYEHRRDYDKTALVQKMEQAVENFNCSRS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26PhosphorylationSSSSEDDCFERRTKR
CCCCHHHHHHHHHHH		6.20-
65PhosphorylationDRMKIGASLADVDPM
CCCCCCCCCCCCCHH		20.91-
77PhosphorylationDPMQLDTSVRFDSVG
CHHHCCCCCCCCCCC		15.8030482847
147PhosphorylationSRGDKRVAFFMRKGA
CCCCHHHHHHHHCCH		8.94-
162PhosphorylationDCLSKWVGESERQLR
HHHHHHCCCCHHHHH		31.43-
168PhosphorylationVGESERQLRLLFDQA
CCCCHHHHHHHHHHH		5.36-
173UbiquitinationRQLRLLFDQAYQMRP
HHHHHHHHHHHHHCC		31.97-
176PhosphorylationRLLFDQAYQMRPAII
HHHHHHHHHHCCEEE		9.3726239621
234PhosphorylationGATNRLDSIDPALRR
ECCCCHHCCCHHHCC		33.2230482847
286PhosphorylationLEELAEHCVGYCGAD
HHHHHHHHHHHCCCC		1.59-
290PhosphorylationAEHCVGYCGADIKSI
HHHHHHHCCCCHHHH		2.74-
303PhosphorylationSICAEAALCALRRRY
HHHHHHHHHHHHHHC		1.9524719451
307PhosphorylationEAALCALRRRYPQIY
HHHHHHHHHHCCCCE		11.51-
315PhosphorylationRRYPQIYTTSEKLQL
HHCCCCEECCCCEEC		26.0222871156
316PhosphorylationRYPQIYTTSEKLQLD
HCCCCEECCCCEECC		20.2322871156
317PhosphorylationYPQIYTTSEKLQLDL
CCCCEECCCCEECCH		25.57-
318PhosphorylationPQIYTTSEKLQLDLS
CCCEECCCCEECCHH		56.55-
322PhosphorylationTTSEKLQLDLSSITI
ECCCCEECCHHHCEE		11.80-
324PhosphorylationSEKLQLDLSSITISA
CCCEECCHHHCEEEH		6.18-
325PhosphorylationEKLQLDLSSITISAK
CCEECCHHHCEEEHH		21.2522871156
326PhosphorylationKLQLDLSSITISAKD
CEECCHHHCEEEHHH		30.9226745281
328PhosphorylationQLDLSSITISAKDFE
ECCHHHCEEEHHHHH		15.7226745281
330PhosphorylationDLSSITISAKDFEAA
CHHHCEEEHHHHHHH		22.1826745281
345PhosphorylationLQKIRPASQRAVTSP
HHHHCCHHHHCCCCH		23.92-
350PhosphorylationPASQRAVTSPGQALS
CHHHHCCCCHHHHHH		28.3726745281
351PhosphorylationASQRAVTSPGQALSA
HHHHCCCCHHHHHHH		22.0426745281
392PhosphorylationGTNKSLNSDVSCPFL
CCCCCCCCCCCCCCH		44.6925619855
401PhosphorylationVSCPFLESDLAYSDD
CCCCCHHCCCCCCCC		39.8225619855
405PhosphorylationFLESDLAYSDDDTPS
CHHCCCCCCCCCCHH		21.6725619855
406PhosphorylationLESDLAYSDDDTPSV
HHCCCCCCCCCCHHH		29.0225619855
410PhosphorylationLAYSDDDTPSVYENG
CCCCCCCCHHHHHCC		25.1825619855
412PhosphorylationYSDDDTPSVYENGLS
CCCCCCHHHHHCCCC		39.1525619855
414PhosphorylationDDDTPSVYENGLSQK
CCCCHHHHHCCCCHH		14.1725619855
591PhosphorylationDLILKQASKPPVSQK
HHHHHHCCCCCCCHH		43.11-
646PhosphorylationRIFLRNVTHRLAIDK
HHHHHHHHHHHHHCC		12.58-
780PhosphorylationHVMPKQNSPPVGDKK
CCCCCCCCCCCCCCC		28.2527087446
797AcetylationQEQNEKLKVPCTPVA
HHHHHCCCCCCCCCC		56.0222826441
801PhosphorylationEKLKVPCTPVACSTP
HCCCCCCCCCCCCCH		18.0921082442
806PhosphorylationPCTPVACSTPAQLKR
CCCCCCCCCHHHHHH		27.9125619855
807PhosphorylationCTPVACSTPAQLKRK
CCCCCCCCHHHHHHH		23.6425619855
825PhosphorylationKSKWHVGTKIKRRKI
CCCCCCCHHHHHCCH		28.62-
849PhosphorylationAMNSSSRSDTEDSQH
CCCCCCCCCCCCCCC		51.3228973931
862PhosphorylationQHTHAEHTEPGNTDE
CCCCCCCCCCCCCCH		35.0730387612
867PhosphorylationEHTEPGNTDESSVEE
CCCCCCCCCHHHHHH		47.2428973931
870PhosphorylationEPGNTDESSVEESDK
CCCCCCHHHHHHHHH		42.3628973931
883PhosphorylationDKQNRLESNIDLKNN
HHHCHHHHCCCCCCC		43.6122817900
891PhosphorylationNIDLKNNSSSSNIEN
CCCCCCCCCCCCHHH		40.7822802335
892PhosphorylationIDLKNNSSSSNIENE
CCCCCCCCCCCHHHH		39.6522802335
893PhosphorylationDLKNNSSSSNIENEL
CCCCCCCCCCHHHHH		27.5022802335
894PhosphorylationLKNNSSSSNIENELE
CCCCCCCCCHHHHHC		43.7222942356
924PhosphorylationIVCRGDASASQVTDI
EEEECCCCHHHCCCC		32.9425619855
926PhosphorylationCRGDASASQVTDIPE
EECCCCHHHCCCCCC		23.7628066266
929PhosphorylationDASASQVTDIPEDSE
CCCHHHCCCCCCCCC		22.1525619855
935PhosphorylationVTDIPEDSESKEMDF
CCCCCCCCCCHHHHH		41.9525619855
937PhosphorylationDIPEDSESKEMDFLR
CCCCCCCCHHHHHHH		37.5625619855
951PhosphorylationRMTLARGSQVEQQEL
HHHHHCCCHHHHHHC		26.04-
972PhosphorylationLAILSQPTPSLVLDH
HHHHHCCCCCEECCH		20.20-
1038PhosphorylationAVENFNCSRS-----
HHHHCCCCCC-----		36.3419060867
1040PhosphorylationENFNCSRS-------
HHCCCCCC-------		28.4221183079
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATAD2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATAD2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATAD2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ATAD2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATAD2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-801, AND MASSSPECTROMETRY.

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