SNX6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNX6_MOUSE
• UniProt AC: Q6P8X1
• Protein Name: Sorting nexin-6
• Gene Name: Snx6
• Organism: Mus musculus (Mouse).
• Sequence Length: 406
• Subcellular Localization: Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle . Cytoplasm . Nucleus . Interaction with SNX1 or SNX2 promotes location at endosome membranes (By similarity). Only a minor proportion is seen in the nucle
• Protein Description: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity (By similarity). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation (By similarity). In association with GIT1 involved in EGFR degradation. [PubMed: 18523162 Promotes lysosomal degradation of CDKN1B]
• Protein Sequence: MMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDRVKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRKDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMEGLDDG -------CCCCCCCC	5.07	-
2	Acetylation	------MMEGLDDGP ------CCCCCCCCC	5.86	-
13	Phosphorylation	DDGPDFLSEEDRGLK CCCCCCCCHHHCCCC	38.64	25338131
60	Ubiquitination	KSSLPNFKQNEFSVV CCCCCCCCCCCCCHH	59.87	22790023
116	Phosphorylation	KLGEGEGSMTKEEFT HHCCCCCCCCHHHHH	20.98	29176673
118	Phosphorylation	GEGEGSMTKEEFTKM CCCCCCCCHHHHHHH	36.68	29176673
119	Ubiquitination	EGEGSMTKEEFTKMK CCCCCCCHHHHHHHH	46.75	22790023
149	Glutathionylation	AMHEVFLCRVAAHPI HHHHHHHHHHHHCHH	1.92	24333276
194	Phosphorylation	FFKNMVKSADGVIVS HHHHHHHCCCCEEEC	21.85	23375375
269	Ubiquitination	DICKFFLKVSELFDK HHHHHHHHHHHHHHH	38.26	22790023
276	Malonylation	KVSELFDKTRKIEAR HHHHHHHHHCCEEEE	42.78	26320211
276	Ubiquitination	KVSELFDKTRKIEAR HHHHHHHHHCCEEEE	42.78	-
297	Ubiquitination	LKLSDLLKYYLRESQ CCHHHHHHHHHHHCH	38.86	22790023
298	Phosphorylation	KLSDLLKYYLRESQA CHHHHHHHHHHHCHH	14.01	29899451
307	Ubiquitination	LRESQAAKDLLYRRS HHHCHHHHHHHHHHH	52.50	22790023
314	Phosphorylation	KDLLYRRSRSLVDYE HHHHHHHHHHHCCHH	19.75	26643407
316	Phosphorylation	LLYRRSRSLVDYENA HHHHHHHHHCCHHHH	33.71	26643407
325	Ubiquitination	VDYENANKALDKARA CCHHHHHHHHHHHHH	48.17	22790023
329	Ubiquitination	NANKALDKARAKNKD HHHHHHHHHHHCCHH	40.39	27667366
350	Acetylation	SQQLCCQKFEKISES HHHHHHHHHHHHCHH	41.39	22826441
366	Ubiquitination	KQELIDFKTRRVAAF HHHHHHHHHHHHHHH	37.06	22790023
386	Ubiquitination	ELAELELKHAKGNLQ HHHHHHHHHCCHHHH	31.94	22790023
406	Phosphorylation	LAVLNGDT------- HHHHCCCC-------	41.74	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNX6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNX6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNX6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GIT1_MOUSE	Git1	physical	18523162

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.