VATC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATC1_MOUSE
• UniProt AC: Q9Z1G3
• Protein Name: V-type proton ATPase subunit C 1
• Gene Name: Atp6v1c1
• Organism: Mus musculus (Mouse).
• Sequence Length: 382
• Protein Description: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
• Protein Sequence: MTEFWLISAPGEKTCQQTWEKLHAATTKNNNLAVSSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLASGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFRKAVDDFRHKARENKFIVRDFQYNEEEMKADKEEMTRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVNFQAMLLQPNKKSVKKLREVLHELYKHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYKIDCNLLEFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTEFWLISA ------CCEEEEEEC	39.63	-
15	Glutathionylation	SAPGEKTCQQTWEKL ECCCCHHHHHHHHHH	4.12	24333276
28	Ubiquitination	KLHAATTKNNNLAVS HHHHHCCCCCCEEEC	54.01	27667366
75	Phosphorylation	VVKKVAQYMADVLED HHHHHHHHHHHHHHH	5.64	25159016
83	Phosphorylation	MADVLEDSKDKVQEN HHHHHHHCHHHHHHH	33.12	25159016
86	Ubiquitination	VLEDSKDKVQENLLA HHHHCHHHHHHHHHH	49.94	-
115	Ubiquitination	DMAKYPIKQSLKNIS HHHCCCHHHHHCCHH	29.36	27667366
127	Ubiquitination	NISEIIAKGVTQIDN CHHHHHHHCCHHCCH	43.43	-
137	Ubiquitination	TQIDNDLKSRASAYN HHCCHHHHHHHHHHH	40.53	-
138	Phosphorylation	QIDNDLKSRASAYNN HCCHHHHHHHHHHHH	40.14	29899451
141	Phosphorylation	NDLKSRASAYNNLKG HHHHHHHHHHHHHHH	30.12	29899451
143	Phosphorylation	LKSRASAYNNLKGNL HHHHHHHHHHHHHHH	11.33	29514104
147	Ubiquitination	ASAYNNLKGNLQNLE HHHHHHHHHHHHHHH	48.12	-
156	Ubiquitination	NLQNLERKNAGSLLT HHHHHHHHCHHHHHH	41.60	27667366
240	Ubiquitination	AVDDFRHKARENKFI HHHHHHHHHHCCCCE	44.90	-
245	Ubiquitination	RHKARENKFIVRDFQ HHHHHCCCCEEECCC	31.54	27667366
259	Ubiquitination	QYNEEEMKADKEEMT CCCHHHHHCCHHHHH	57.63	-
262	Ubiquitination	EEEMKADKEEMTRLS HHHHHCCHHHHHHHC	61.51	-
274	Ubiquitination	RLSTDKKKQFGPLVR HHCCHHHHHHHHHHH	57.51	27667366
367	Phosphorylation	NLSQQEYYPYVYYKI CCCCCCCCCEEEEEE	6.32	-
376	S-nitrosocysteine	YVYYKIDCNLLEFK- EEEEEEECCEEECC-	4.38	-
376	S-nitrosylation	YVYYKIDCNLLEFK- EEEEEEECCEEECC-	4.38	20925432

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of VATC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.