| UniProt ID | SYTM_MOUSE | |
|---|---|---|
| UniProt AC | Q3UQ84 | |
| Protein Name | Threonine--tRNA ligase, mitochondrial | |
| Gene Name | Tars2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 723 | |
| Subcellular Localization | Mitochondrion matrix. | |
| Protein Description | Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain.. | |
| Protein Sequence | MGLCLRWRRLGFPLPEFRRCELHTVREASAPTPPHWLAERFGLFEELWTAHVKKLASMTQKKARAIKISLPEGQKVDAVAWNTTPYQLAHQISVTLADTAVAAEVNGELYDLDRPLETDCHLRFLTFDSPEGKAVFWHSSAHVLGAAAEQQLGAVLCRGPSTESGFYHDFFLGKERTVRSAELPILERICQELIAAAQPFRRLEASRDQLRQLFKDNHFKLHLIEEKVTGPTATVYGCGMSVDLCRGPHLRHTGQIGALKLLTNSSALWRSLGAPETLQRVSGISFPKVELLRNWEARREAAELRDHRRIGKEQELFFFHELSPGSCFFLPRGTRVYNALVAFIRAEYARRGFSEVKTPTLFSTKLWEQSGHWEHYRADMFSLKPPGTDGVDNSQSGHPARCPKDTLALKPMNCPAHCLMFAHRPRSWRELPVRLADFGALHRAEASGSLGGLTRLWRFQQDDAHIFCAPHQLEAEIQGCLDFLRCVYSVLGFSFHLALSTRPPGFLGEPRLWDQAEQVLQQALEKFGEPWDLNPGDGAFYGPKIDVHLHDALGRPHQCGTIQLDFQLPLRFDLQYKGPAGTPECPVLIHRAVLGSVERLLGVLAESCGGKWPLWLSPLQVVVIPVRTEQEEYARQVQQCLQAAGLVSDLDADSGLTLSRRVRRAQLAHYNFQFVVGQREQSQRTVNVRTRDNRQLGERDLAESVQRLLELQNARVPNAEEVF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 57 | Phosphorylation | AHVKKLASMTQKKAR HHHHHHHHCCHHHHH | 32.57 | - | |
| 263 | Phosphorylation | IGALKLLTNSSALWR CCCHHHHHCCHHHHH | 43.41 | 26060331 | |
| 265 | Phosphorylation | ALKLLTNSSALWRSL CHHHHHCCHHHHHHC | 16.26 | 26060331 | |
| 266 | Phosphorylation | LKLLTNSSALWRSLG HHHHHCCHHHHHHCC | 29.47 | 26060331 | |
| 384 | Acetylation | RADMFSLKPPGTDGV EECEEECCCCCCCCC | 48.22 | 23864654 | |
| 585 | S-nitrosocysteine | GPAGTPECPVLIHRA CCCCCCCCCHHHHHH | 2.73 | - | |
| 585 | S-nitrosylation | GPAGTPECPVLIHRA CCCCCCCCCHHHHHH | 2.73 | 21278135 | |
| 608 | S-palmitoylation | LGVLAESCGGKWPLW HHHHHHHCCCCCCEE | 6.66 | 28526873 | |
| 659 | Phosphorylation | ADSGLTLSRRVRRAQ CCCCCCHHHHHHHHH | 16.89 | 23140645 | |
| 689 | Methylation | SQRTVNVRTRDNRQL CCCEEEEECCCCHHH | 20.88 | 30989473 | |
| 704 | Phosphorylation | GERDLAESVQRLLEL CCHHHHHHHHHHHHH | 20.24 | 28066266 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYTM_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYTM_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYTM_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SYTM_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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