RL12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL12_MOUSE
• UniProt AC: P35979
• Protein Name: 60S ribosomal protein L12
• Gene Name: Rpl12
• Organism: Mus musculus (Mouse).
• Sequence Length: 165
• Protein Description: Binds directly to 26S ribosomal RNA..
• Protein Sequence: MPPKFDPNEVKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGLRITVKLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDEIVNIARQMRHRSLARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECPAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Glutathionylation	VKVVYLRCTGGEVGA CEEEEEEECCCCCCC	3.70	24333276
17	S-nitrosocysteine	VKVVYLRCTGGEVGA CEEEEEEECCCCCCC	3.70	-
17	S-nitrosylation	VKVVYLRCTGGEVGA CEEEEEEECCCCCCC	3.70	21278135
17	S-palmitoylation	VKVVYLRCTGGEVGA CEEEEEEECCCCCCC	3.70	28526873
18	Phosphorylation	KVVYLRCTGGEVGAT EEEEEEECCCCCCCC	41.61	20139300
38	Phosphorylation	KIGPLGLSPKKVGDD CCCCCCCCHHHHCHH	32.64	26824392
40	Acetylation	GPLGLSPKKVGDDIA CCCCCCHHHHCHHHH	57.63	90307
40	Malonylation	GPLGLSPKKVGDDIA CCCCCCHHHHCHHHH	57.63	26320211
41	Malonylation	PLGLSPKKVGDDIAK CCCCCHHHHCHHHHH	55.63	26320211
48	Ubiquitination	KVGDDIAKATGDWKG HHCHHHHHHHCCCCC	46.98	-
48	Malonylation	KVGDDIAKATGDWKG HHCHHHHHHHCCCCC	46.98	26320211
48	Acetylation	KVGDDIAKATGDWKG HHCHHHHHHHCCCCC	46.98	23236377
54	Acetylation	AKATGDWKGLRITVK HHHHCCCCCEEEEEE	53.45	23864654
54	Malonylation	AKATGDWKGLRITVK HHHHCCCCCEEEEEE	53.45	26320211
61	Ubiquitination	KGLRITVKLTIQNRQ CCEEEEEEEEEECCC	31.12	22790023
76	Phosphorylation	AQIEVVPSASALIIK HHEEEECCHHHHHHH	24.20	22006019
83	Ubiquitination	SASALIIKALKEPPR CHHHHHHHHHCCCCC	40.44	22790023
83	Acetylation	SASALIIKALKEPPR CHHHHHHHHHCCCCC	40.44	22826441
86	Malonylation	ALIIKALKEPPRDRK HHHHHHHCCCCCCHH	73.38	26320211
99	Ubiquitination	RKKQKNIKHSGNITF HHHHHCCCCCCCCCH	40.90	22790023
120	Phosphorylation	ARQMRHRSLARELSG HHHHHHHHHHHHHHH	21.91	29550500
126	Phosphorylation	RSLARELSGTIKEIL HHHHHHHHHHHHHHH	29.18	22942356
128	Phosphorylation	LARELSGTIKEILGT HHHHHHHHHHHHHCH	26.04	26745281
130	Ubiquitination	RELSGTIKEILGTAQ HHHHHHHHHHHCHHH	38.24	22790023
135	Phosphorylation	TIKEILGTAQSVGCN HHHHHHCHHHHCCCC	20.34	26160508
141	Glutathionylation	GTAQSVGCNVDGRHP CHHHHCCCCCCCCCH	4.15	24333276
141	S-nitrosylation	GTAQSVGCNVDGRHP CHHHHCCCCCCCCCH	4.15	21278135
141	S-nitrosocysteine	GTAQSVGCNVDGRHP CHHHHCCCCCCCCCH	4.15	-
141	S-palmitoylation	GTAQSVGCNVDGRHP CHHHHCCCCCCCCCH	4.15	28526873
157	Phosphorylation	DIIDDINSGAVECPA HCCCCCCCCCCCCCC	28.59	30635358
162	S-nitrosocysteine	INSGAVECPAS---- CCCCCCCCCCC----	2.47	-
162	S-nitrosylation	INSGAVECPAS---- CCCCCCCCCCC----	2.47	21278135
162	S-palmitoylation	INSGAVECPAS---- CCCCCCCCCCC----	2.47	28526873
165	Phosphorylation	GAVECPAS------- CCCCCCCC-------	26.37	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL12_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RL12_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL12_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RL12_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.