LAS1L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAS1L_MOUSE
• UniProt AC: A2BE28
• Protein Name: Ribosomal biogenesis protein LAS1L
• Gene Name: Las1l
• Organism: Mus musculus (Mouse).
• Sequence Length: 776
• Subcellular Localization: Nucleus, nucleolus. Nucleus, nucleoplasm . Cytoplasm . Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export (By similarity). Mainly found in the nucleoplasm, with low
• Protein Description: Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes..
• Protein Sequence: MDRVWRAWDGQSFKENQPESPSARGIVVSWLSRAEWEQVTVYLFCDDHKLQQYALNRITVWRSRLGNELPLAVASTADLVRCKLIDAAGTLGTDELRLLYGMALVRFVNLISERKTKCSNLPLKYLAQEVNIPDWIVELRHNLTHKKMPHINECRRGCYFVLNWLQKTYWSRQLEGSLKETWELDEDQLDAEDPEEEEREIIADDVLEEIPEPQDDDKDEELAVEDDANTKGNEEVASHPEPSSRHKELYEKARELLVSYEEEQFKVLEKHRHLLQAIKVWNNLSPRVQCILEELKSISWENRDAVLDAFLDDGFLIPTFEQLAALQIEYEDGQTEVQKGEVTEPNSHKNIDLNEVLVPKPFSQFWQPLLRGLHSQTFTQALLERMFSELSTVGSTGIRPTYILRWTVELIVANTKTGRNARRFSASQWEARKSWRLFNCSATLDWPQVIESCLGSPCWASPQLLQVVFKAMGQVLPDEEQEKLLRVCSIYTQNGENGLAKAIEGSSSSSTGKAPYTLDTLHEDLQPPGTNCESEESIQQKEQGNLKDVKQEEKKENEEEEKEEEEMEEEEEEEEEEKEEEEEEQEQEEHQEEEQEEEEEEENQKVFQDQMEADVEESDDVEEEEEVDDEEEDEDDDYDDDEEEDRMEVGAFSLAQGSSVFENTRTTSRKREALQGSAWQVSSEDVRWGTFPLGRLPGQTEDPAELMLDNYDTMYLLDQPVIEHRLEPQKSKSSTLSLCCGGSNTNSSSSSSSGNMEGLLWNQGQMHGLKAGLQLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	WRAWDGQSFKENQPE CCCCCCCCHHHCCCC	43.76	25619855
14	Ubiquitination	AWDGQSFKENQPESP CCCCCCHHHCCCCCC	62.09	22790023
20	Phosphorylation	FKENQPESPSARGIV HHHCCCCCCCCCCCE	30.73	25619855
22	Phosphorylation	ENQPESPSARGIVVS HCCCCCCCCCCCEEE	39.62	25619855
116	Phosphorylation	NLISERKTKCSNLPL HHHCCCCCCCCCCCH	43.43	28059163
238	Phosphorylation	KGNEEVASHPEPSSR CCCHHHHHCCCCCHH	44.76	25159016
243	Phosphorylation	VASHPEPSSRHKELY HHHCCCCCHHHHHHH	38.04	18779572
244	Phosphorylation	ASHPEPSSRHKELYE HHCCCCCHHHHHHHH	49.47	18779572
425	Phosphorylation	GRNARRFSASQWEAR CCCCCCCCHHHHHHH	25.79	23684622
483	Ubiquitination	LPDEEQEKLLRVCSI CCHHHHHHHHHHHHH	53.14	22790023
509	Phosphorylation	AIEGSSSSSTGKAPY HHCCCCCCCCCCCCC	33.59	-
530	Phosphorylation	EDLQPPGTNCESEES HHCCCCCCCCCCHHH	42.33	25293948
534	Phosphorylation	PPGTNCESEESIQQK CCCCCCCCHHHHHHH	49.19	25293948
537	Phosphorylation	TNCESEESIQQKEQG CCCCCHHHHHHHHHC	22.96	25293948
658	Phosphorylation	AFSLAQGSSVFENTR HHHHHCCCCHHCCCC	15.96	-
677	Phosphorylation	KREALQGSAWQVSSE HHHHHCCCCEEECCC	17.24	28066266
682	Phosphorylation	QGSAWQVSSEDVRWG CCCCEEECCCCCCCC	16.95	28066266
683	Phosphorylation	GSAWQVSSEDVRWGT CCCEEECCCCCCCCC	38.67	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LAS1L_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAS1L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAS1L_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LAS1L_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.