| UniProt ID | GARS_MOUSE | |
|---|---|---|
| UniProt AC | Q9CZD3 | |
| Protein Name | Glycine--tRNA ligase | |
| Gene Name | Gars | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 729 | |
| Subcellular Localization | Cytoplasm . Cell projection, axon . Secreted . Secreted, exosome . Associated with granules in cultured neuron cells (By similarity). Secreted by motor neuron and differentiated myotube cell lines, but not by undifferentiated myoblasts, possibly thro | |
| Protein Description | Catalyzes the ligation of glycine to the 3'-end of its cognate tRNA. Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs (By similarity).. | |
| Protein Sequence | MPCLLPSLLRATRAALPLLSPPRVVAASASQRLLSAPAQPAASRSSMDSAEELLAPLRLAVRQQGDFVRKLKEDKAPQVDVDRAVAELKARKRVLEAKELALQPKDDIVDRAKMEDTLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQAWRQHFIQEEQILEIDCTMLTPEPVLKTSGHVDKFADFMVKDVKNGECFRADHLLKAHLQKLMSDKKCSAEKKSEMESVLAQLDNYGQQELADLFVNYNVKSPTTGNDLSPPVPFNLMFQTFIGPGGNMPGYLRPETAQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRSGLIRVREFTMAEIEHFVDPTEKDHPKFQSVADLCLYLYSAKAQVTGQSARKMRLGDAVEQGVINNSVLGYFIGRIYLYLTKVGISPDKLRFRQHMENEMAHYACDCWDAESKTSYGWIEIVGCADRSCYDLSCHARATKVPLVAEKPLKEPKTVNVVQFEPNKGAVGKAYKKDAKLVLEYLSACDECYISEMELLLSEKGEFTIETEGKTFQLTKDMVSVKRFQKTLHVEEVVPSVIEPSFGLGRIMYTILEHTFHVREGDEQRTFFSFPAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRNGVSHKVDDSSGSIGRRYARTDEIGVAFGITIDFDTVNKTPHTATLRDRDSMRQIRAEVSELPNVVRDLANGNITWADVEARYPLFEGQETGKKETVEE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 30 | Phosphorylation | RVVAASASQRLLSAP CEEEECHHHHHHCCC | 29514104 | ||
| 89 | Succinylation | DRAVAELKARKRVLE HHHHHHHHHHHHHHH | 23806337 | ||
| 89 | Ubiquitination | DRAVAELKARKRVLE HHHHHHHHHHHHHHH | 27667366 | ||
| 89 | Acetylation | DRAVAELKARKRVLE HHHHHHHHHHHHHHH | 23806337 | ||
| 98 | Succinylation | RKRVLEAKELALQPK HHHHHHHHHHHCCCC | 23806337 | ||
| 98 | Acetylation | RKRVLEAKELALQPK HHHHHHHHHHHCCCC | 23806337 | ||
| 98 | Ubiquitination | RKRVLEAKELALQPK HHHHHHHHHHHCCCC | 27667366 | ||
| 187 | Acetylation | KTSGHVDKFADFMVK CCCCCHHHHHHEEEE | 22826441 | ||
| 187 | Ubiquitination | KTSGHVDKFADFMVK CCCCCHHHHHHEEEE | 22790023 | ||
| 194 | Acetylation | KFADFMVKDVKNGEC HHHHEEEEECCCCCC | 23236377 | ||
| 194 | Succinylation | KFADFMVKDVKNGEC HHHHEEEEECCCCCC | 23954790 | ||
| 209 | Acetylation | FRADHLLKAHLQKLM CCHHHHHHHHHHHHH | 22826441 | ||
| 214 | Acetylation | LLKAHLQKLMSDKKC HHHHHHHHHHCCCCC | 22826441 | ||
| 308 | Ubiquitination | LLEFNQGKLPFAAAQ HHHHCCCCCCCCHHH | 22790023 | ||
| 319 | Phosphorylation | AAAQIGNSFRNEISP CHHHHCHHHCCCCCC | 26643407 | ||
| 325 | Phosphorylation | NSFRNEISPRSGLIR HHHCCCCCCCCCEEE | 26643407 | ||
| 328 | Phosphorylation | RNEISPRSGLIRVRE CCCCCCCCCEEEEEE | - | ||
| 350 | Acetylation | HFVDPTEKDHPKFQS CCCCCCCCCCHHHHH | 23806337 | ||
| 357 | Phosphorylation | KDHPKFQSVADLCLY CCCHHHHHHHHHHHH | 26643407 | ||
| 369 | Ubiquitination | CLYLYSAKAQVTGQS HHHHHHHCCCHHCCC | - | ||
| 376 | Phosphorylation | KAQVTGQSARKMRLG CCCHHCCCHHHCCHH | 23684622 | ||
| 394 | Phosphorylation | EQGVINNSVLGYFIG HHCCCCHHHHHHHHH | - | ||
| 398 | Phosphorylation | INNSVLGYFIGRIYL CCHHHHHHHHHHHHH | - | ||
| 404 | Phosphorylation | GYFIGRIYLYLTKVG HHHHHHHHHHHHHCC | 25619855 | ||
| 406 | Phosphorylation | FIGRIYLYLTKVGIS HHHHHHHHHHHCCCC | 25619855 | ||
| 408 | Phosphorylation | GRIYLYLTKVGISPD HHHHHHHHHCCCCHH | 25619855 | ||
| 409 | Ubiquitination | RIYLYLTKVGISPDK HHHHHHHHCCCCHHH | 22790023 | ||
| 413 | Phosphorylation | YLTKVGISPDKLRFR HHHHCCCCHHHHHHH | 25619855 | ||
| 416 | Ubiquitination | KVGISPDKLRFRQHM HCCCCHHHHHHHHHH | - | ||
| 441 | Phosphorylation | CWDAESKTSYGWIEI CCCCCCCCCCCEEEE | 25367039 | ||
| 442 | Phosphorylation | WDAESKTSYGWIEIV CCCCCCCCCCEEEEE | 25367039 | ||
| 443 | Phosphorylation | DAESKTSYGWIEIVG CCCCCCCCCEEEEEE | 22817900 | ||
| 474 | Acetylation | KVPLVAEKPLKEPKT CCCEEEECCCCCCCE | 23806337 | ||
| 491 | Acetylation | VVQFEPNKGAVGKAY EEEEECCCCCCCCHH | 23236377 | ||
| 491 | Malonylation | VVQFEPNKGAVGKAY EEEEECCCCCCCCHH | 26320211 | ||
| 496 | Ubiquitination | PNKGAVGKAYKKDAK CCCCCCCCHHHHHHH | 27667366 | ||
| 543 | Acetylation | GKTFQLTKDMVSVKR CEEEEEECCHHHHHH | 22826441 | ||
| 640 | Phosphorylation | VSHKVDDSSGSIGRR CCCCCCCCCCCCCCH | 28066266 | ||
| 641 | Phosphorylation | SHKVDDSSGSIGRRY CCCCCCCCCCCCCHH | 26824392 | ||
| 643 | Phosphorylation | KVDDSSGSIGRRYAR CCCCCCCCCCCHHEE | 26824392 | ||
| 690 | Phosphorylation | RQIRAEVSELPNVVR HHHHHHHHHCCHHHH | 23527152 | ||
| 721 | Phosphorylation | PLFEGQETGKKETVE CCCCCCCCCCCCCCC | 25338131 | ||
| 723 | Ubiquitination | FEGQETGKKETVEE- CCCCCCCCCCCCCC- | 22790023 | ||
| 724 | Ubiquitination | EGQETGKKETVEE-- CCCCCCCCCCCCC-- | 22790023 | ||
| 726 | Phosphorylation | QETGKKETVEE---- CCCCCCCCCCC---- | 25338131 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GARS_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GARS_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GARS_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GARS_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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