COMD3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COMD3_MOUSE
• UniProt AC: Q63829
• Protein Name: COMM domain-containing protein 3
• Gene Name: Commd3
• Organism: Mus musculus (Mouse).
• Sequence Length: 195
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits..
• Protein Sequence: MELSESVQRGIQTLADPGSFDSNAFALLLRAAFQSLLDARADEAALDHPYLKQIDPVVLKHCHAAAATCILEAGKHQVDKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLETLLGSIGRSLPHITDVSWRLEYQIKTNQLHKMYRPGYLVTLNVENNDSQSYPEINFSCNMEQLQDLVGKLKDASKSLERATQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Ubiquitination	ALDHPYLKQIDPVVL HCCCHHHHCCCHHHH	39.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COMD3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COMD3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COMD3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of COMD3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.