GCP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCP2_MOUSE
• UniProt AC: Q921G8
• Protein Name: Gamma-tubulin complex component 2
• Gene Name: Tubgcp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 905
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
• Protein Description: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome..
• Protein Sequence: MSEFRIHHDVNELLSLLRIHGGDGAEVYIDLLQKNRTPYVTTTVSAHSAKVKIAEFSRTPEDFLKKYDELKSKNTRNLDPLVYLLSKLTEDKETLQFLQQNAKERAELAASAATSNTTSFSIPVAASKMSTQELEELRKQLGSVSTGSTLQQSLELTRKMLRDKQNKKNSGQPLPVFPAWVYERPTLAGDFLIGSGLSSDTVLPIGTLPLASQESAVVEDLLYVLVGVDGRYITAQPLAGRQNRTFLVDPNLDLSIRELVNRILPVAASYSTVTRFIEEKSSFEYGQVNHALAAAMRTLVKEYLILVTQLEQLHRQGLLSLQKLWFYIQPAMRTIDILASLATSVDKGECVGGSTLSLLHDRSFNYTGDSQAQELCLYLTKAASAPYFEILEKWIYRGIIHDPYSEFMVEEHELRKEKIQEDYNDKYWDQRYTVLPQQIPSFLQKVAGKILSTGKYLNVVRECGHDVTCPVAKEIIYTLKERAYVEQIEKAFNYASKVLLDFLMEEKELVAHLRSIKRYFLMDQGDFFVHFMDLTEEELRKPVEDIILTRLEALLELALRMSTANTDPFKDDLKIELMPHDLITQLLRVLAIETKQEKAMTHADPTELTLSGLEAFSFDYMVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQLCSVWISNKTAKQHALHSAKWFAGAFTLRQRMLNFVQNIQYYMMFEVMEPTWHILEKNLKSASNIDDVLGHHTSFLDNCLKDCMLTNPELLKVFSKLMSVCVMFTNCMQKFTQSMKLDSELGRLTLDQGSVQGPPTETERIEDRPRKELTRKHLSEHVDAPQLASGFEATINNFDKNFSAHLLDLLARLSVYSTSDCEHGMASVISRLDFNGFYAERLERLSAERSQKAAPQVPVPRGPSAPAPRVAIPAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	Phosphorylation	RNLDPLVYLLSKLTE CCCHHHHHHHHHHCC	15.03	22817900
130	Phosphorylation	PVAASKMSTQELEEL HHHHCCCCHHHHHHH	30.58	22817900
146	Phosphorylation	KQLGSVSTGSTLQQS HHHCCCCCCHHHHHH	32.75	26487105
149	Phosphorylation	GSVSTGSTLQQSLEL CCCCCCHHHHHHHHH	29.90	26487105
320	Phosphorylation	LHRQGLLSLQKLWFY HHHCCCCHHHHHHHH	33.52	22942356
378	Phosphorylation	QAQELCLYLTKAASA HHHHHHHHHHHHHCC	16.01	29514104
380	Phosphorylation	QELCLYLTKAASAPY HHHHHHHHHHHCCCH	12.70	29514104
455	Ubiquitination	GKILSTGKYLNVVRE HHHHCCCCHHHHHHH	46.80	22790023
455	Ubiquitination	GKILSTGKYLNVVRE HHHHCCCCHHHHHHH	46.80	22790023
594	Phosphorylation	LRVLAIETKQEKAMT HHHHHHHCCHHHHCC	31.73	29109428
711	Acetylation	PTWHILEKNLKSASN CHHHHHHHHHHCCCC	65.22	7721463
714	Acetylation	HILEKNLKSASNIDD HHHHHHHHCCCCHHH	54.06	7721473
809	Phosphorylation	ELTRKHLSEHVDAPQ HHHHHHHHHCCCHHH	25.94	29899451
819	Phosphorylation	VDAPQLASGFEATIN CCHHHHHHCHHHHHC	53.24	29899451
899	Methylation	GPSAPAPRVAIPAQ- CCCCCCCCCCCCCC-	32.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GCP3_HUMAN	TUBGCP3	physical	20360068
GCP2_HUMAN	TUBGCP2	physical	20360068
TBG1_HUMAN	TUBG1	physical	20360068
MZT2B_HUMAN	MZT2B	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.