SMC4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMC4_MOUSE
• UniProt AC: Q8CG47
• Protein Name: Structural maintenance of chromosomes protein 4
• Gene Name: Smc4
• Organism: Mus musculus (Mouse).
• Sequence Length: 1286
• Subcellular Localization: Nucleus. Cytoplasm. Chromosome. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromos
• Protein Description: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity)..
• Protein Sequence: MRRKGTKPSTACHQEEGPPPSQDGAHSDEEMEQPAGEAESAAPAKPPGEELDNRSLEEILNSIPPPPPPAMASEAGAPRLMITHIVNQNFKSYAGEKVLGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVLPNSNFYVSRTAYRDSTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEMFKKKNHICQYYIYDLQNRIAEITTQKEKIHEDTKEITEKSNVLSNEMKAKNSAVKDVEKKLNKVTKFIEQNKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEELKSVPAKSKTVINETTTRNNSLEKEREKEEKKLKEVMDSLKQETQGLQKEKEIQEKELMGFNKSVNEARSKMEVAQSELDIYLSRHNTAVSQLSKAKEALITASETLKERKAAIKDINTKLPQTQQELKEKEKELQKLTQEEINLKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDIAISSCCHALDYIVVDSIDTAQECVNFLKKHNIGIATFIGLDKMTVWAKKMSKIQTPENTPRLFDLVKVKNEEIRQAFYFALRDTLVANNLDQATRVAYQRDRRWRVVTLQGQIIEQSGTMSGGGSKVMRGRMGSSVIDEISVEEVNKMESQLERHSKQAMQIQEQKVQHEEAVVKLRHSERDMRNTLEKFAASIQGLSEQEEYLCVQIKELEANVLTTAPDRKQQKLLEENVSVFKKEYDAVAEKAGKVEAEIKRLHNTIIDINNRKLKAQQNKLDTINKQLDECASAITKAQVAIKTADRNLKKAQDSVCRTEKEIKDTEKEINDLKTELKNIEDKAEEVINNTKTAETSLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHISEHNSKIKYWQKEISKIKLHPVEDNPVETVAVLSQEELEAIKNPESITNEIALLEAQCREMKPNLGAIAEYKKKEDLYLQRVAELDKITSERDNFRQAYEDLRKQRLNEFMAGFYVITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNSTKSVAVNPKQIASKGLC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RKGTKPSTACHQEEG CCCCCCCCCCCCCCC	41.66	22668510
21	Phosphorylation	QEEGPPPSQDGAHSD CCCCCCCCCCCCCCH	46.83	25159016
27	Phosphorylation	PSQDGAHSDEEMEQP CCCCCCCCHHHCCCC	46.30	25159016
40	Phosphorylation	QPAGEAESAAPAKPP CCCCCCCCCCCCCCC	36.46	22668510
141	Phosphorylation	KIRSKKLSVLIHNSD HHHHCCEEEEEECCC	24.61	25338131
186	Phosphorylation	SNFYVSRTAYRDSTS CCEEEEEEEEECCCE	22.12	24759943
198	Phosphorylation	STSVYHISGKKKTFK CCEEEEECCCCCCHH	31.11	24759943
269	Glutathionylation	NEPIKVLCRRVEILN CHHHHHHHHHHHHHH	2.67	24333276
372	Acetylation	SAVKDVEKKLNKVTK HHHHHHHHHHHHHHH	63.51	7615635
376	Acetylation	DVEKKLNKVTKFIEQ HHHHHHHHHHHHHHH	62.81	7615645
379	Acetylation	KKLNKVTKFIEQNKE HHHHHHHHHHHHCHH	47.54	23806337
464	Phosphorylation	KLKEVMDSLKQETQG HHHHHHHHHHHHHHH	21.26	28285833
474	Acetylation	QETQGLQKEKEIQEK HHHHHHHHHHHHHHH	75.65	24062335
673	Phosphorylation	FIGLDKMTVWAKKMS EECCCHHHHHHHHHH	20.73	18779572
677	Acetylation	DKMTVWAKKMSKIQT CHHHHHHHHHHCCCC	33.04	-
763	Phosphorylation	VMRGRMGSSVIDEIS HHCCCCCCCHHCCCC	16.46	29899451
764	Phosphorylation	MRGRMGSSVIDEISV HCCCCCCCHHCCCCH	19.84	29899451
770	Phosphorylation	SSVIDEISVEEVNKM CCHHCCCCHHHHHHH	22.79	29899451
862	Phosphorylation	KLLEENVSVFKKEYD HHHHHCHHHHHHHHH	33.16	27600695
883	Acetylation	GKVEAEIKRLHNTII CCHHHHHHHHHHHEE	40.17	23864654
957	Acetylation	EKEINDLKTELKNIE HHHHHHHHHHHHCHH	42.70	23236377
958	Phosphorylation	KEINDLKTELKNIED HHHHHHHHHHHCHHH	54.57	25777480
979	Phosphorylation	NNTKTAETSLPEIQK HCCCCCCCCCHHHHH	32.85	28066266
980	Phosphorylation	NTKTAETSLPEIQKE CCCCCCCCCHHHHHH	33.17	28066266
1152	Phosphorylation	KENYQMLTLGGDAEL HHCEEEEECCCCCEE	20.29	-
1164	Phosphorylation	AELELVDSLDPFSEG CEEEEHHHCCCCCCC	27.48	-
1185	Ubiquitination	PPKKSWKKIFNLSGG CCCCCHHHHHCCCCC	46.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMC4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMC4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMC4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CND1_HUMAN	NCAPD2	physical	26496610
SMC2_HUMAN	SMC2	physical	26496610
CNDD3_HUMAN	NCAPD3	physical	26496610
CND2_HUMAN	NCAPH	physical	26496610
CNDH2_HUMAN	NCAPH2	physical	26496610
CNDG2_HUMAN	NCAPG2	physical	26496610
CND3_HUMAN	NCAPG	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.