ANLN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANLN_MOUSE
• UniProt AC: Q8K298
• Protein Name: Anillin
• Gene Name: Anln
• Organism: Mus musculus (Mouse).
• Sequence Length: 1121
• Subcellular Localization: Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex . Cell projection, bleb . Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area o
• Protein Description: Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration..
• Protein Sequence: MDPFTEKLLERTRARRENLQRKMAERPTAVARSAPHAKRGREPLSEASNQQQPLPGGEEKSCTKPSPSKKRCSDKIEVGAPDLENTEPIDVAKPCSPMPAPRQAKPPAPAAISESVAAPAALLSADRGLNSGSEASATSSVKTRMQRLAEQRRHWDSDLTDDVSESSYFAPVPTEDKAASPSKPPISNASATPVGRRGRLANLAATICSWEDDVSHSSAKQNSVQEQPGTACLSKSSSASGASASINSSSVQQEATCCSPRDGNASVRKDPSSNAAHGPLLSASVSSSVKASSPVTAATFITENREAQNPELLHKTASPLKTEARKPCEKPTLSQGAQPKEEANREVCLQSQSKDKLATPGGRGIKPFLERFGERCQEHSKESPSYRASHKTPNITPNTKAIQERLFKQNTCSSTTHLAQQLKQEREKELACLRGRLDKGNLWSAEKNEKSRSKHLETKQEVHCQNTPLKKHQTVASTPLTSVTDKVAENEPAVKLSSTEPAGSTESEMTKSSPLKITLFLEEEKSLKVASDLEVEQNTEAVREVEMSVDDEDINSSRVINDIFSDVLEEGELDVEKSQEEMDQVGAENSEEQEDALNISSMSLLAPLAQTVGVVSLENVISSPPSELRDSNLSAASPKPGKFQRTRVPRAESADSLGSEDRDLLYSIDAYRSQRFKETERPSIKQVIVRKEDVTSKLGEKKNVFSGQVNIKQKMQELNNDINLQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATEKRALLIDELNKLKSEGPQRRNKTSVISQSEFAPSKGSVTLSEICLPLKADFVCSTAQKTDASNYYYLIMLKAGAEQMVATPLASTANSLSGDALTFPTTFTLHDVSNDFEINIEVYSLVQKKDSLGPDKKKKASKSKAITPKRLLTSITSKSSLHSSVMASPGGLGAVRTSNFTLVGSHTLSLSSVGDTKFALDKVPFLSPLEGHICLKISCQVNSAVEEKGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDERRKNPIGRINLANCISHQIEPANREFCARRNTLELITVRPQREDDRETLVSQCRDTLCVTKNWLSADTKEERDLWMQKLNQVIVDIRLWQPDACYKPVGKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPFTEKL -------CCHHHHHH	55.46	-
61	Phosphorylation	LPGGEEKSCTKPSPS CCCCCCCCCCCCCCC	30.23	126572443
66	Phosphorylation	EKSCTKPSPSKKRCS CCCCCCCCCCCCCCC	43.28	24453211
68	Phosphorylation	SCTKPSPSKKRCSDK CCCCCCCCCCCCCCC	55.96	24453211
73	Phosphorylation	SPSKKRCSDKIEVGA CCCCCCCCCCCEECC	46.07	25619855
96	Phosphorylation	IDVAKPCSPMPAPRQ CCCCCCCCCCCCCCC	32.53	26824392
124	Phosphorylation	AAPAALLSADRGLNS HHHHHHHHCCCCCCC	29.04	22067460
131	Phosphorylation	SADRGLNSGSEASAT HCCCCCCCCCHHHCH	49.06	28973931
140	Phosphorylation	SEASATSSVKTRMQR CHHHCHHHHHHHHHH	24.23	27149854
164	Phosphorylation	SDLTDDVSESSYFAP CCCCCCCCHHCCCCC	38.46	24453211
166	Phosphorylation	LTDDVSESSYFAPVP CCCCCCHHCCCCCCC	23.88	24453211
174	Phosphorylation	SYFAPVPTEDKAASP CCCCCCCCCCCCCCC	57.98	22006019
180	Phosphorylation	PTEDKAASPSKPPIS CCCCCCCCCCCCCCC	34.27	27087446
182	Phosphorylation	EDKAASPSKPPISNA CCCCCCCCCCCCCCC	56.13	22942356
187	Phosphorylation	SPSKPPISNASATPV CCCCCCCCCCCCCCC	31.92	25168779
190	Phosphorylation	KPPISNASATPVGRR CCCCCCCCCCCCCCH	36.60	25168779
192	Phosphorylation	PISNASATPVGRRGR CCCCCCCCCCCCHHH	18.93	26824392
206	Phosphorylation	RLANLAATICSWEDD HHHHHHHHHHCCCCC	19.53	23984901
209	Phosphorylation	NLAATICSWEDDVSH HHHHHHHCCCCCCCC	29.65	26643407
215	Phosphorylation	CSWEDDVSHSSAKQN HCCCCCCCCCHHHHC	25.33	23984901
217	Phosphorylation	WEDDVSHSSAKQNSV CCCCCCCCHHHHCCC	25.20	23984901
218	Phosphorylation	EDDVSHSSAKQNSVQ CCCCCCCHHHHCCCC	33.78	23984901
223	Phosphorylation	HSSAKQNSVQEQPGT CCHHHHCCCCCCCCC	23.76	18637093
236	Phosphorylation	GTACLSKSSSASGAS CCEEEECCCCCCCCC	26.58	25619855
237	Phosphorylation	TACLSKSSSASGASA CEEEECCCCCCCCCC	33.39	25619855
238	Phosphorylation	ACLSKSSSASGASAS EEEECCCCCCCCCCC	33.28	25619855
240	Phosphorylation	LSKSSSASGASASIN EECCCCCCCCCCCCC	36.52	25619855
243	Phosphorylation	SSSASGASASINSSS CCCCCCCCCCCCCCC	26.52	25619855
245	Phosphorylation	SASGASASINSSSVQ CCCCCCCCCCCCCCC	21.58	25619855
248	Phosphorylation	GASASINSSSVQQEA CCCCCCCCCCCCEEC	23.48	25619855
249	Phosphorylation	ASASINSSSVQQEAT CCCCCCCCCCCEECC	30.00	25619855
250	Phosphorylation	SASINSSSVQQEATC CCCCCCCCCCEECCE	24.62	25619855
256	Phosphorylation	SSVQQEATCCSPRDG CCCCEECCEECCCCC	17.19	25619855
259	Phosphorylation	QQEATCCSPRDGNAS CEECCEECCCCCCCC	25.72	27087446
266	Phosphorylation	SPRDGNASVRKDPSS CCCCCCCCCCCCCCC	26.84	26643407
292	Phosphorylation	VSSSVKASSPVTAAT CCCCCCCCCCCEEEE	29.47	21082442
293	Phosphorylation	SSSVKASSPVTAATF CCCCCCCCCCEEEEE	28.40	27087446
296	Phosphorylation	VKASSPVTAATFITE CCCCCCCEEEEEECC	17.60	22942356
299	Phosphorylation	SSPVTAATFITENRE CCCCEEEEEECCCHH	17.07	25619855
302	Phosphorylation	VTAATFITENREAQN CEEEEEECCCHHHCC	24.02	25619855
316	Phosphorylation	NPELLHKTASPLKTE CHHHHHCCCCCCCCC	22.94	25159016
318	Phosphorylation	ELLHKTASPLKTEAR HHHHCCCCCCCCCCC	35.68	26824392
322	Phosphorylation	KTASPLKTEARKPCE CCCCCCCCCCCCCCC	42.43	20139300
332	Phosphorylation	RKPCEKPTLSQGAQP CCCCCCCCCCCCCCC	50.54	37011165
334	Phosphorylation	PCEKPTLSQGAQPKE CCCCCCCCCCCCCHH	29.10	33651687
353	Phosphorylation	EVCLQSQSKDKLATP HHHHHHCCCCCCCCC	48.33	18779572
359	Phosphorylation	QSKDKLATPGGRGIK CCCCCCCCCCCCCHH	32.66	28066266
366	Acetylation	TPGGRGIKPFLERFG CCCCCCHHHHHHHHH	32.32	23236377
380	Phosphorylation	GERCQEHSKESPSYR HHHHHHHHCCCCCHH	37.05	25266776
383	Phosphorylation	CQEHSKESPSYRASH HHHHHCCCCCHHHCC	23.92	25266776
389	Phosphorylation	ESPSYRASHKTPNIT CCCCHHHCCCCCCCC	19.27	28066266
392	Phosphorylation	SYRASHKTPNITPNT CHHHCCCCCCCCCCH	19.02	18779572
396	Phosphorylation	SHKTPNITPNTKAIQ CCCCCCCCCCHHHHH	19.68	1526413
399	Phosphorylation	TPNITPNTKAIQERL CCCCCCCHHHHHHHH	24.05	30351991
414	Phosphorylation	FKQNTCSSTTHLAQQ HCCCCCCHHHHHHHH	39.20	-
444	Phosphorylation	LDKGNLWSAEKNEKS CCCCCCCCHHCCHHH	29.71	28973931
451	Phosphorylation	SAEKNEKSRSKHLET CHHCCHHHHHHCCCH	35.29	28059163
453	Phosphorylation	EKNEKSRSKHLETKQ HCCHHHHHHCCCHHH	31.36	28059163
467	Phosphorylation	QEVHCQNTPLKKHQT HHHHCCCCCCCCCCC	12.24	11223457
477	Phosphorylation	KKHQTVASTPLTSVT CCCCCCCCCCCCCCC	26.65	28066266
478	Phosphorylation	KHQTVASTPLTSVTD CCCCCCCCCCCCCCH	16.75	25619855
481	Phosphorylation	TVASTPLTSVTDKVA CCCCCCCCCCCHHHH	23.50	25619855
482	Phosphorylation	VASTPLTSVTDKVAE CCCCCCCCCCHHHHC	30.61	25619855
484	Phosphorylation	STPLTSVTDKVAENE CCCCCCCCHHHHCCC	29.84	25619855
497	Phosphorylation	NEPAVKLSSTEPAGS CCCCEECCCCCCCCC	29.51	25619855
498	Phosphorylation	EPAVKLSSTEPAGST CCCEECCCCCCCCCC	47.42	25619855
499	Phosphorylation	PAVKLSSTEPAGSTE CCEECCCCCCCCCCC	42.48	25619855
504	Phosphorylation	SSTEPAGSTESEMTK CCCCCCCCCCCCCCC	30.98	25619855
505	Phosphorylation	STEPAGSTESEMTKS CCCCCCCCCCCCCCC	42.48	25619855
507	Phosphorylation	EPAGSTESEMTKSSP CCCCCCCCCCCCCCC	32.53	25619855
509	Oxidation	AGSTESEMTKSSPLK CCCCCCCCCCCCCCE	8.77	17242355
510	Phosphorylation	GSTESEMTKSSPLKI CCCCCCCCCCCCCEE	24.59	25293948
512	Phosphorylation	TESEMTKSSPLKITL CCCCCCCCCCCEEEE	28.20	26824392
513	Phosphorylation	ESEMTKSSPLKITLF CCCCCCCCCCEEEEE	35.49	26824392
526	Phosphorylation	LFLEEEKSLKVASDL EEECHHHCCCHHCCC	36.38	22817900
531	Phosphorylation	EKSLKVASDLEVEQN HHCCCHHCCCEEHHC	45.79	26824392
548	Phosphorylation	AVREVEMSVDDEDIN HHHEEEECCCHHHHC	14.64	25521595
556	Phosphorylation	VDDEDINSSRVINDI CCHHHHCCHHHHHHH	21.61	25619855
557	Phosphorylation	DDEDINSSRVINDIF CHHHHCCHHHHHHHH	26.53	6453389
565	Phosphorylation	RVINDIFSDVLEEGE HHHHHHHHHHHHHCC	27.43	41455209
623	Phosphorylation	SLENVISSPPSELRD EHHHHHCCCCHHHCC	29.70	7806845
631	Phosphorylation	PPSELRDSNLSAASP CCHHHCCCCCCCCCC	32.98	25619855
634	Phosphorylation	ELRDSNLSAASPKPG HHCCCCCCCCCCCCC	26.49	25619855
637	Phosphorylation	DSNLSAASPKPGKFQ CCCCCCCCCCCCCCC	32.92	25521595
653	Phosphorylation	TRVPRAESADSLGSE CCCCCCCCCCCCCCC	36.07	25521595
656	Phosphorylation	PRAESADSLGSEDRD CCCCCCCCCCCCCHH	34.05	25521595
659	Phosphorylation	ESADSLGSEDRDLLY CCCCCCCCCCHHHHH	41.43	25521595
666	Phosphorylation	SEDRDLLYSIDAYRS CCCHHHHHHHHHHHH	15.75	25159016
667	Phosphorylation	EDRDLLYSIDAYRSQ CCHHHHHHHHHHHHH	17.60	29899451
673	Phosphorylation	YSIDAYRSQRFKETE HHHHHHHHHCCCCCC	17.03	144473
683	Phosphorylation	FKETERPSIKQVIVR CCCCCCCCCEEEEEE	48.95	30815193
706	Phosphorylation	GEKKNVFSGQVNIKQ CCCCCCCCCCCCHHH	24.84	29899451
786	Phosphorylation	GPQRRNKTSVISQSE CCCCCCCCEEEECHH	31.60	21183079
787	Phosphorylation	PQRRNKTSVISQSEF CCCCCCCEEEECHHC	21.04	22817900
790	Phosphorylation	RNKTSVISQSEFAPS CCCCEEEECHHCCCC	26.04	23984901
792	Phosphorylation	KTSVISQSEFAPSKG CCEEEECHHCCCCCC	28.08	26239621
887	Phosphorylation	SLVQKKDSLGPDKKK EHHHCHHCCCCCCCC	44.07	29899451
909	Phosphorylation	ITPKRLLTSITSKSS CCHHHHHHHHCCCHH	23.75	29895711
910	Phosphorylation	TPKRLLTSITSKSSL CHHHHHHHHCCCHHC	24.68	20415495
912	Phosphorylation	KRLLTSITSKSSLHS HHHHHHHCCCHHCCC	29.84	20415495
913	Phosphorylation	RLLTSITSKSSLHSS HHHHHHCCCHHCCCH	28.95	31437835
915	Phosphorylation	LTSITSKSSLHSSVM HHHHCCCHHCCCHHC	37.59	23984901
916	Phosphorylation	TSITSKSSLHSSVMA HHHCCCHHCCCHHCC	33.56	23984901
919	Phosphorylation	TSKSSLHSSVMASPG CCCHHCCCHHCCCCC	29.89	23984901
920	Phosphorylation	SKSSLHSSVMASPGG CCHHCCCHHCCCCCC	12.74	23984901
924	Phosphorylation	LHSSVMASPGGLGAV CCCHHCCCCCCCCEE	13.14	26239621
970	S-nitrosocysteine	SPLEGHICLKISCQV CCCCCCEEEEEEEEE	2.35	-
970	S-nitrosylation	SPLEGHICLKISCQV CCCCCCEEEEEEEEE	2.35	20925432
974	Phosphorylation	GHICLKISCQVNSAV CCEEEEEEEEECCHH	9.26	29514104
979	Phosphorylation	KISCQVNSAVEEKGF EEEEEECCHHHHCCC	34.53	29514104
1116	Acetylation	WQPDACYKPVGKP-- CCCCCCCCCCCCC--	32.86	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANLN_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANLN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANLN_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANLN_HUMAN	ANLN	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-637, AND MASSSPECTROMETRY.
PubMed: 19144319

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-637, AND MASSSPECTROMETRY.
PubMed: 19367708

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-510, AND MASSSPECTROMETRY.
PubMed: 17242355