dbPTM

ANLN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ANLN_HUMAN
UniProt AC	Q9NQW6
Protein Name	Anillin
Gene Name	ANLN
Organism	Homo sapiens (Human).
Sequence Length	1124
Subcellular Localization	Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex . Cell projection, bleb . Mainly found in the nucleus during interphase. Colocalizes with cortical F-actin upon nuclear envelope breakdown in mitosis and subsequently concentrates in the area o
Protein Description	Required for cytokinesis. [PubMed: 16040610 Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis]
Protein Sequence	MDPFTEKLLERTRARRENLQRKMAERPTAAPRSMTHAKRARQPLSEASNQQPLSGGEEKSCTKPSPSKKRCSDNTEVEVSNLENKQPVESTSAKSCSPSPVSPQVQPQAADTISDSVAVPASLLGMRRGLNSRLEATAASSVKTRMQKLAEQRRRWDNDDMTDDIPESSLFSPMPSEEKAASPPRPLLSNASATPVGRRGRLANLAATICSWEDDVNHSFAKQNSVQEQPGTACLSKFSSASGASARINSSSVKQEATFCSQRDGDASLNKALSSSADDASLVNASISSSVKATSPVKSTTSITDAKSCEGQNPELLPKTPISPLKTGVSKPIVKSTLSQTVPSKGELSREICLQSQSKDKSTTPGGTGIKPFLERFGERCQEHSKESPARSTPHRTPIITPNTKAIQERLFKQDTSSSTTHLAQQLKQERQKELACLRGRFDKGNIWSAEKGGNSKSKQLETKQETHCQSTPLKKHQGVSKTQSLPVTEKVTENQIPAKNSSTEPKGFTECEMTKSSPLKITLFLEEDKSLKVTSDPKVEQKIEVIREIEMSVDDDDINSSKVINDLFSDVLEEGELDMEKSQEEMDQALAESSEEQEDALNISSMSLLAPLAQTVGVVSPESLVSTPRLELKDTSRSDESPKPGKFQRTRVPRAESGDSLGSEDRDLLYSIDAYRSQRFKETERPSIKQVIVRKEDVTSKLDEKNNAFPCQVNIKQKMQELNNEINMQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATGKRTLLIDELNKLKNEGPQRKNKASPQSEFMPSKGSVTLSEIRLPLKADFVCSTVQKPDAANYYYLIILKAGAENMVATPLASTSNSLNGDALTFTTTFTLQDVSNDFEINIEVYSLVQKKDPSGLDKKKKTSKSKAITPKRLLTSITTKSNIHSSVMASPGGLSAVRTSNFALVGSYTLSLSSVGNTKFVLDKVPFLSSLEGHIYLKIKCQVNSSVEERGFLTIFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKNPIGRINLANCTSRQIEPANREFCARRNTFELITVRPQREDDRETLVSQCRDTLCVTKNWLSADTKEERDLWMQKLNQVLVDIRLWQPDACYKPIGKP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPFTEKL -------CCHHHHHH	55.46	22814378
45	Phosphorylation	KRARQPLSEASNQQP HHHCCCHHHHHCCCC	37.49	24732914
48	Phosphorylation	RQPLSEASNQQPLSG CCCHHHHHCCCCCCC	30.99	24732914
54	Phosphorylation	ASNQQPLSGGEEKSC HHCCCCCCCCCCCCC	51.97	29255136
60	Phosphorylation	LSGGEEKSCTKPSPS CCCCCCCCCCCCCCC	30.23	29396449
62	Phosphorylation	GGEEKSCTKPSPSKK CCCCCCCCCCCCCCC	53.75	28985074
65	Phosphorylation	EKSCTKPSPSKKRCS CCCCCCCCCCCCCCC	43.28	30278072
67	Phosphorylation	SCTKPSPSKKRCSDN CCCCCCCCCCCCCCC	55.96	29396449
72	Phosphorylation	SPSKKRCSDNTEVEV CCCCCCCCCCCEEEE	37.62	29255136
75	Phosphorylation	KKRCSDNTEVEVSNL CCCCCCCCEEEEECC	46.53	30266825
80	Phosphorylation	DNTEVEVSNLENKQP CCCEEEEECCCCCCC	23.38	30266825
85	Ubiquitination	EVSNLENKQPVESTS EEECCCCCCCCCCCC	46.75	-
90	Phosphorylation	ENKQPVESTSAKSCS CCCCCCCCCCCCCCC	28.09	24732914
91	Phosphorylation	NKQPVESTSAKSCSP CCCCCCCCCCCCCCC	21.14	26074081
92	Phosphorylation	KQPVESTSAKSCSPS CCCCCCCCCCCCCCC	42.87	24732914
95	Phosphorylation	VESTSAKSCSPSPVS CCCCCCCCCCCCCCC	21.39	30278072
96	Glutathionylation	ESTSAKSCSPSPVSP CCCCCCCCCCCCCCC	7.36	22555962
97	Phosphorylation	STSAKSCSPSPVSPQ CCCCCCCCCCCCCCC	35.19	30278072
99	Phosphorylation	SAKSCSPSPVSPQVQ CCCCCCCCCCCCCCC	22.95	30278072
102	Phosphorylation	SCSPSPVSPQVQPQA CCCCCCCCCCCCCCC	17.01	30278072
112	Phosphorylation	VQPQAADTISDSVAV CCCCCCCCCCHHCHH	20.04	30278072
114	Phosphorylation	PQAADTISDSVAVPA CCCCCCCCHHCHHHH	26.40	23663014
116	Phosphorylation	AADTISDSVAVPASL CCCCCCHHCHHHHHH	12.75	23663014
122	Phosphorylation	DSVAVPASLLGMRRG HHCHHHHHHHHHHCC	20.32	22199227
132	Phosphorylation	GMRRGLNSRLEATAA HHHCCHHHHHHHHHH	43.20	28555341
137	Phosphorylation	LNSRLEATAASSVKT HHHHHHHHHHHHHHH	17.24	29255136
140	Phosphorylation	RLEATAASSVKTRMQ HHHHHHHHHHHHHHH	32.95	29255136
141	Phosphorylation	LEATAASSVKTRMQK HHHHHHHHHHHHHHH	23.94	29255136
143	Ubiquitination	ATAASSVKTRMQKLA HHHHHHHHHHHHHHH	32.15	-
148	Acetylation	SVKTRMQKLAEQRRR HHHHHHHHHHHHHHH	40.08	26051181
162	Phosphorylation	RWDNDDMTDDIPESS HCCCCCCCCCCCHHH	37.20	23090842
168	Phosphorylation	MTDDIPESSLFSPMP CCCCCCHHHCCCCCC	27.30	22199227
169	Phosphorylation	TDDIPESSLFSPMPS CCCCCHHHCCCCCCC	31.60	30576142
172	Phosphorylation	IPESSLFSPMPSEEK CCHHHCCCCCCCHHH	26.11	25159151
176	Phosphorylation	SLFSPMPSEEKAASP HCCCCCCCHHHCCCC	52.73	22199227
182	Phosphorylation	PSEEKAASPPRPLLS CCHHHCCCCCCCCCC	40.05	22617229
189	Phosphorylation	SPPRPLLSNASATPV CCCCCCCCCCCCCCC	37.72	10729039
192	Phosphorylation	RPLLSNASATPVGRR CCCCCCCCCCCCCCH	36.60	30278072
194	Phosphorylation	LLSNASATPVGRRGR CCCCCCCCCCCCHHH	18.93	25159151
208	Phosphorylation	RLANLAATICSWEDD HHHHHHHHHHCHHHH	19.53	24732914
211	Phosphorylation	NLAATICSWEDDVNH HHHHHHHCHHHHCCC	29.65	24732914
219	Phosphorylation	WEDDVNHSFAKQNSV HHHHCCCCHHHHCCC	22.99	24732914
225	Phosphorylation	HSFAKQNSVQEQPGT CCHHHHCCCCCCCCC	23.76	25159151
232	Phosphorylation	SVQEQPGTACLSKFS CCCCCCCCCHHHHHH	22.38	29396449
236	Phosphorylation	QPGTACLSKFSSASG CCCCCHHHHHHCCCC	31.38	29396449
237	Acetylation	PGTACLSKFSSASGA CCCCHHHHHHCCCCC	36.00	26051181
237	Ubiquitination	PGTACLSKFSSASGA CCCCHHHHHHCCCCC	36.00	-
239	Phosphorylation	TACLSKFSSASGASA CCHHHHHHCCCCCCC	28.82	22199227
240	Phosphorylation	ACLSKFSSASGASAR CHHHHHHCCCCCCCC	29.59	22199227
242	Phosphorylation	LSKFSSASGASARIN HHHHHCCCCCCCCCC	36.52	22199227
245	Phosphorylation	FSSASGASARINSSS HHCCCCCCCCCCCHH	22.93	22199227
250	Phosphorylation	GASARINSSSVKQEA CCCCCCCCHHHCCEE	22.94	63748127
251	Phosphorylation	ASARINSSSVKQEAT CCCCCCCHHHCCEEE	34.36	29978859
252	Phosphorylation	SARINSSSVKQEATF CCCCCCHHHCCEEEE	32.90	29978859
254	Sumoylation	RINSSSVKQEATFCS CCCCHHHCCEEEEEC	44.35	-
254	Acetylation	RINSSSVKQEATFCS CCCCHHHCCEEEEEC	44.35	26051181
254	Sumoylation	RINSSSVKQEATFCS CCCCHHHCCEEEEEC	44.35	25114211
254	Ubiquitination	RINSSSVKQEATFCS CCCCHHHCCEEEEEC	44.35	-
258	Phosphorylation	SSVKQEATFCSQRDG HHHCCEEEEECCCCC	25.15	28555341
261	Phosphorylation	KQEATFCSQRDGDAS CCEEEEECCCCCCHH	24.86	35091971
268	Phosphorylation	SQRDGDASLNKALSS CCCCCCHHHHHHHCC	36.90	63759717
271	Ubiquitination	DGDASLNKALSSSAD CCCHHHHHHHCCCCC	56.87	-
274	Phosphorylation	ASLNKALSSSADDAS HHHHHHHCCCCCHHH	27.40	29507054
275	Phosphorylation	SLNKALSSSADDASL HHHHHHCCCCCHHHH	30.32	22199227
276	Phosphorylation	LNKALSSSADDASLV HHHHHCCCCCHHHHC	32.13	22199227
281	Phosphorylation	SSSADDASLVNASIS CCCCCHHHHCHHHHC	39.58	28555341
286	Phosphorylation	DASLVNASISSSVKA HHHHCHHHHCCCCCC	20.14	28555341
288	Phosphorylation	SLVNASISSSVKATS HHCHHHHCCCCCCCC	17.67	25159151
289	Phosphorylation	LVNASISSSVKATSP HCHHHHCCCCCCCCC	37.16	21712546
290	Phosphorylation	VNASISSSVKATSPV CHHHHCCCCCCCCCC	22.35	28348404
294	Phosphorylation	ISSSVKATSPVKSTT HCCCCCCCCCCCCCC	28.04	30266825
295	Phosphorylation	SSSVKATSPVKSTTS CCCCCCCCCCCCCCC	32.33	23401153
299	Phosphorylation	KATSPVKSTTSITDA CCCCCCCCCCCCCCC	36.83	30266825
300	Phosphorylation	ATSPVKSTTSITDAK CCCCCCCCCCCCCCH	20.88	30266825
301	Phosphorylation	TSPVKSTTSITDAKS CCCCCCCCCCCCCHH	25.81	30266825
302	Phosphorylation	SPVKSTTSITDAKSC CCCCCCCCCCCCHHC	24.47	25159151
304	Phosphorylation	VKSTTSITDAKSCEG CCCCCCCCCCHHCCC	29.67	23927012
307	Ubiquitination	TTSITDAKSCEGQNP CCCCCCCHHCCCCCC	59.45	-
308	Phosphorylation	TSITDAKSCEGQNPE CCCCCCHHCCCCCCC	21.08	30266825
320	Phosphorylation	NPELLPKTPISPLKT CCCCCCCCCCCCCCC	24.74	25159151
323	Phosphorylation	LLPKTPISPLKTGVS CCCCCCCCCCCCCCC	25.94	19664994
327	Phosphorylation	TPISPLKTGVSKPIV CCCCCCCCCCCCCHH	50.96	27273156
330	Phosphorylation	SPLKTGVSKPIVKST CCCCCCCCCCHHHHH	33.78	24732914
331	Acetylation	PLKTGVSKPIVKSTL CCCCCCCCCHHHHHH	36.04	26051181
336	Phosphorylation	VSKPIVKSTLSQTVP CCCCHHHHHHCCCCC	24.56	22199227
337	Phosphorylation	SKPIVKSTLSQTVPS CCCHHHHHHCCCCCC	25.39	22199227
339	Phosphorylation	PIVKSTLSQTVPSKG CHHHHHHCCCCCCCC	24.72	28355574
341	Phosphorylation	VKSTLSQTVPSKGEL HHHHHCCCCCCCCCC	30.89	25159151
344	Phosphorylation	TLSQTVPSKGELSRE HHCCCCCCCCCCCHH	49.29	25159151
345	Acetylation	LSQTVPSKGELSREI HCCCCCCCCCCCHHH	50.78	26051181
345	Ubiquitination	LSQTVPSKGELSREI HCCCCCCCCCCCHHH	50.78	-
349	Phosphorylation	VPSKGELSREICLQS CCCCCCCCHHHHHHC	24.46	72249487
356	Phosphorylation	SREICLQSQSKDKST CHHHHHHCCCCCCCC	24.39	63708323
358	Phosphorylation	EICLQSQSKDKSTTP HHHHHCCCCCCCCCC	48.33	21815630
359	Ubiquitination	ICLQSQSKDKSTTPG HHHHCCCCCCCCCCC	62.63	-
362	Phosphorylation	QSQSKDKSTTPGGTG HCCCCCCCCCCCCCC	47.88	30266825
363	Phosphorylation	SQSKDKSTTPGGTGI CCCCCCCCCCCCCCH	42.63	30266825
364	Phosphorylation	QSKDKSTTPGGTGIK CCCCCCCCCCCCCHH	27.33	22322096
368	Phosphorylation	KSTTPGGTGIKPFLE CCCCCCCCCHHHHHH	41.47	30266825
371	Acetylation	TPGGTGIKPFLERFG CCCCCCHHHHHHHHH	30.94	19608861
371	Ubiquitination	TPGGTGIKPFLERFG CCCCCCHHHHHHHHH	30.94	19608861
385	Phosphorylation	GERCQEHSKESPARS HHHHHHHHCCCCCCC	37.05	28985074
388	Phosphorylation	CQEHSKESPARSTPH HHHHHCCCCCCCCCC	27.83	22199227
392	Phosphorylation	SKESPARSTPHRTPI HCCCCCCCCCCCCCC	48.69	25159151
393	Phosphorylation	KESPARSTPHRTPII CCCCCCCCCCCCCCC	19.98	30278072
397	Phosphorylation	ARSTPHRTPIITPNT CCCCCCCCCCCCCCH	18.79	30266825
401	Phosphorylation	PHRTPIITPNTKAIQ CCCCCCCCCCHHHHH	15.94	30266825
404	Phosphorylation	TPIITPNTKAIQERL CCCCCCCHHHHHHHH	24.05	30266825
405	Acetylation	PIITPNTKAIQERLF CCCCCCHHHHHHHHH	50.56	26051181
413	Sumoylation	AIQERLFKQDTSSST HHHHHHHCCCCCCHH	52.43	-
413	Acetylation	AIQERLFKQDTSSST HHHHHHHCCCCCCHH	52.43	26051181
413	Sumoylation	AIQERLFKQDTSSST HHHHHHHCCCCCCHH	52.43	-
413	Ubiquitination	AIQERLFKQDTSSST HHHHHHHCCCCCCHH	52.43	-
416	Phosphorylation	ERLFKQDTSSSTTHL HHHHCCCCCCHHHHH	28.19	25159151
417	Phosphorylation	RLFKQDTSSSTTHLA HHHCCCCCCHHHHHH	30.49	25159151
418	Phosphorylation	LFKQDTSSSTTHLAQ HHCCCCCCHHHHHHH	33.52	25159151
419	Phosphorylation	FKQDTSSSTTHLAQQ HCCCCCCHHHHHHHH	36.77	25159151
420	Phosphorylation	KQDTSSSTTHLAQQL CCCCCCHHHHHHHHH	21.86	25159151
421	Phosphorylation	QDTSSSTTHLAQQLK CCCCCHHHHHHHHHH	19.48	21955146
428	Sumoylation	THLAQQLKQERQKEL HHHHHHHHHHHHHHH	45.86	-
428	Methylation	THLAQQLKQERQKEL HHHHHHHHHHHHHHH	45.86	-
428	Sumoylation	THLAQQLKQERQKEL HHHHHHHHHHHHHHH	45.86	-
428	Ubiquitination	THLAQQLKQERQKEL HHHHHHHHHHHHHHH	45.86	-
433	Ubiquitination	QLKQERQKELACLRG HHHHHHHHHHHHHHC	62.00	-
444	Acetylation	CLRGRFDKGNIWSAE HHHCCCCCCCCCCCC	51.66	25953088
449	Phosphorylation	FDKGNIWSAEKGGNS CCCCCCCCCCCCCCC	23.82	19664994
452	Acetylation	GNIWSAEKGGNSKSK CCCCCCCCCCCCCCC	72.36	25953088
452	Ubiquitination	GNIWSAEKGGNSKSK CCCCCCCCCCCCCCC	72.36	-
456	Phosphorylation	SAEKGGNSKSKQLET CCCCCCCCCCCCCCH	41.40	26425664
458	Phosphorylation	EKGGNSKSKQLETKQ CCCCCCCCCCCCHHH	26.00	21712546
463	Phosphorylation	SKSKQLETKQETHCQ CCCCCCCHHHCCCCC	46.77	23312004
464	Sumoylation	KSKQLETKQETHCQS CCCCCCHHHCCCCCC	36.44	-
464	Sumoylation	KSKQLETKQETHCQS CCCCCCHHHCCCCCC	36.44	-
467	Phosphorylation	QLETKQETHCQSTPL CCCHHHCCCCCCCCC	26.00	29396449
471	Phosphorylation	KQETHCQSTPLKKHQ HHCCCCCCCCCHHCC	37.07	25159151
472	Phosphorylation	QETHCQSTPLKKHQG HCCCCCCCCCHHCCC	13.53	25159151
481	Phosphorylation	LKKHQGVSKTQSLPV CHHCCCCCCCCCCCC	36.49	25627689
482	Acetylation	KKHQGVSKTQSLPVT HHCCCCCCCCCCCCC	48.45	25953088
482	Ubiquitination	KKHQGVSKTQSLPVT HHCCCCCCCCCCCCC	48.45	-
483	Phosphorylation	KHQGVSKTQSLPVTE HCCCCCCCCCCCCCC	18.84	30266825
485	Phosphorylation	QGVSKTQSLPVTEKV CCCCCCCCCCCCCCC	39.61	23927012
489	Phosphorylation	KTQSLPVTEKVTENQ CCCCCCCCCCCCCCC	28.31	30266825
491	Acetylation	QSLPVTEKVTENQIP CCCCCCCCCCCCCCC	45.12	23236377
493	Phosphorylation	LPVTEKVTENQIPAK CCCCCCCCCCCCCCC	40.04	24732914
500	Ubiquitination	TENQIPAKNSSTEPK CCCCCCCCCCCCCCC	52.59	-
502	Phosphorylation	NQIPAKNSSTEPKGF CCCCCCCCCCCCCCC	37.62	27134283
502 (in isoform 2)	Phosphorylation	-	37.62	25159151
503	Phosphorylation	QIPAKNSSTEPKGFT CCCCCCCCCCCCCCE	46.30	27134283
504	Phosphorylation	IPAKNSSTEPKGFTE CCCCCCCCCCCCCEE	57.01	21712546
510	Phosphorylation	STEPKGFTECEMTKS CCCCCCCEEEEECCC	48.68	23663014
515	Phosphorylation	GFTECEMTKSSPLKI CCEEEEECCCCCCEE	12.89	30266825
516	Acetylation	FTECEMTKSSPLKIT CEEEEECCCCCCEEE	47.85	26051181
516 (in isoform 2)	Phosphorylation	-	47.85	25849741
517	Phosphorylation	TECEMTKSSPLKITL EEEEECCCCCCEEEE	28.20	30266825
518	Phosphorylation	ECEMTKSSPLKITLF EEEECCCCCCEEEEE	35.49	22167270
523	Phosphorylation	KSSPLKITLFLEEDK CCCCCEEEEEEECCC	15.18	28152594
530	Ubiquitination	TLFLEEDKSLKVTSD EEEEECCCCCCCCCC	62.05	-
531	Phosphorylation	LFLEEDKSLKVTSDP EEEECCCCCCCCCCH	45.83	21712546
533	Ubiquitination	LEEDKSLKVTSDPKV EECCCCCCCCCCHHH	51.03	-
535	Phosphorylation	EDKSLKVTSDPKVEQ CCCCCCCCCCHHHHH	26.31	22199227
536	Phosphorylation	DKSLKVTSDPKVEQK CCCCCCCCCHHHHHH	55.70	25159151
543	Ubiquitination	SDPKVEQKIEVIREI CCHHHHHHHHHHHEE	27.59	-
552	Sulfoxidation	EVIREIEMSVDDDDI HHHHEEECCCCCCCC	6.09	21406390
553	Phosphorylation	VIREIEMSVDDDDIN HHHEEECCCCCCCCC	15.03	25159151
561	Phosphorylation	VDDDDINSSKVINDL CCCCCCCHHHHHHHH	31.69	30266825
562	Phosphorylation	DDDDINSSKVINDLF CCCCCCHHHHHHHHH	26.84	30266825
570	Phosphorylation	KVINDLFSDVLEEGE HHHHHHHHHHHHHCC	33.82	22199227
583	Phosphorylation	GELDMEKSQEEMDQA CCCCHHHCHHHHHHH	29.53	28348404
594	Phosphorylation	MDQALAESSEEQEDA HHHHHHHCHHHHHHH	37.13	28348404
595	Phosphorylation	DQALAESSEEQEDAL HHHHHHCHHHHHHHH	36.34	28348404
605	Phosphorylation	QEDALNISSMSLLAP HHHHHCCCHHHHHHH	20.93	28348404
606	Phosphorylation	EDALNISSMSLLAPL HHHHCCCHHHHHHHH	14.48	28348404
608	Phosphorylation	ALNISSMSLLAPLAQ HHCCCHHHHHHHHHH	23.37	28348404
616	Phosphorylation	LLAPLAQTVGVVSPE HHHHHHHHHCCCCHH	17.39	28348404
621	Phosphorylation	AQTVGVVSPESLVST HHHHCCCCHHHHHCC	22.12	20873877
624	Phosphorylation	VGVVSPESLVSTPRL HCCCCHHHHHCCCCE	37.14	20873877
627	Phosphorylation	VSPESLVSTPRLELK CCHHHHHCCCCEECC	37.68	20873877
628	Phosphorylation	SPESLVSTPRLELKD CHHHHHCCCCEECCC	12.63	20873877
634	Ubiquitination	STPRLELKDTSRSDE CCCCEECCCCCCCCC	49.97	-
636	Phosphorylation	PRLELKDTSRSDESP CCEECCCCCCCCCCC	25.18	24732914
637	Phosphorylation	RLELKDTSRSDESPK CEECCCCCCCCCCCC	39.66	25159151
639	Phosphorylation	ELKDTSRSDESPKPG ECCCCCCCCCCCCCC	45.56	23927012
642	Phosphorylation	DTSRSDESPKPGKFQ CCCCCCCCCCCCCCC	43.12	28355574
647	Acetylation	DESPKPGKFQRTRVP CCCCCCCCCCCCCCC	47.02	25953088
647	Ubiquitination	DESPKPGKFQRTRVP CCCCCCCCCCCCCCC	47.02	-
651	Phosphorylation	KPGKFQRTRVPRAES CCCCCCCCCCCCCCC	25.82	26074081
658	Phosphorylation	TRVPRAESGDSLGSE CCCCCCCCCCCCCCC	47.09	29255136
661	Phosphorylation	PRAESGDSLGSEDRD CCCCCCCCCCCCCHH	37.85	29255136
664	Phosphorylation	ESGDSLGSEDRDLLY CCCCCCCCCCHHHHH	41.43	20201521
671	Phosphorylation	SEDRDLLYSIDAYRS CCCHHHHHHHHHHHH	15.75	20007894
672	Phosphorylation	EDRDLLYSIDAYRSQ CCHHHHHHHHHHHHH	17.60	21712546
676	Phosphorylation	LLYSIDAYRSQRFKE HHHHHHHHHHHCCCC	13.67	21709757
678	Phosphorylation	YSIDAYRSQRFKETE HHHHHHHHHCCCCCC	17.03	27422710
682	Ubiquitination	AYRSQRFKETERPSI HHHHHCCCCCCCCCC	66.95	-
688	Phosphorylation	FKETERPSIKQVIVR CCCCCCCCCEEEEEE	48.95	25394399
690	Ubiquitination	ETERPSIKQVIVRKE CCCCCCCEEEEEEHH	42.73	-
700	Phosphorylation	IVRKEDVTSKLDEKN EEEHHHHCCHHHHCC	32.25	21955146
701	Phosphorylation	VRKEDVTSKLDEKNN EEHHHHCCHHHHCCC	30.94	21955146
702	Ubiquitination	RKEDVTSKLDEKNNA EHHHHCCHHHHCCCC	51.06	-
706	Ubiquitination	VTSKLDEKNNAFPCQ HCCHHHHCCCCCCCC	55.99	-
717	Ubiquitination	FPCQVNIKQKMQELN CCCCCCHHHHHHHHH	38.37	-
719	Ubiquitination	CQVNIKQKMQELNNE CCCCHHHHHHHHHHH	37.23	-
767	Phosphorylation	ERLLLIATGKRTLLI HHHHHHHHCCCEEHH	35.92	46163265
769	2-Hydroxyisobutyrylation	LLLIATGKRTLLIDE HHHHHHCCCEEHHHH	37.54	-
769	Ubiquitination	LLLIATGKRTLLIDE HHHHHHCCCEEHHHH	37.54	-
771	Phosphorylation	LIATGKRTLLIDELN HHHHCCCEEHHHHHH	29.42	20068231
779	Ubiquitination	LLIDELNKLKNEGPQ EHHHHHHHHHHCCCC	73.74	-
790	Ubiquitination	EGPQRKNKASPQSEF CCCCCCCCCCCCHHC	53.96	-
792	Phosphorylation	PQRKNKASPQSEFMP CCCCCCCCCCHHCCC	25.69	20201521
795	Phosphorylation	KNKASPQSEFMPSKG CCCCCCCHHCCCCCC	35.86	30266825
798	Sulfoxidation	ASPQSEFMPSKGSVT CCCCHHCCCCCCEEE	3.00	21406390
800	Phosphorylation	PQSEFMPSKGSVTLS CCHHCCCCCCEEEEE	37.55	23663014
801	Ubiquitination	QSEFMPSKGSVTLSE CHHCCCCCCEEEEEE	49.70	-
803	Phosphorylation	EFMPSKGSVTLSEIR HCCCCCCEEEEEEEE	18.70	22798277
807	Phosphorylation	SKGSVTLSEIRLPLK CCCEEEEEEEECCCC	22.93	24719451
891	Phosphorylation	LVQKKDPSGLDKKKK EEECCCCCCCCCCCC	63.22	28509920
906	Phosphorylation	TSKSKAITPKRLLTS CCCCCCCCHHHHHHH	27.84	24719451
912	Phosphorylation	ITPKRLLTSITTKSN CCHHHHHHHEECCCC	23.75	23312004
913	Phosphorylation	TPKRLLTSITTKSNI CHHHHHHHEECCCCC	20.22	21712546
915	Phosphorylation	KRLLTSITTKSNIHS HHHHHHEECCCCCCH	28.12	23312004
916	Phosphorylation	RLLTSITTKSNIHSS HHHHHEECCCCCCHH	30.70	23312004
918	Phosphorylation	LTSITTKSNIHSSVM HHHEECCCCCCHHHC	38.64	24732914
922	Phosphorylation	TTKSNIHSSVMASPG ECCCCCCHHHCCCCC	22.34	29255136
923	Phosphorylation	TKSNIHSSVMASPGG CCCCCCHHHCCCCCC	11.18	29255136
927	Phosphorylation	IHSSVMASPGGLSAV CCHHHCCCCCCCCEE	13.14	29255136
932	Phosphorylation	MASPGGLSAVRTSNF CCCCCCCCEEEECCE	28.17	29255136
956	Acetylation	LSSVGNTKFVLDKVP EECCCCCEEEEECCC	37.16	19807547
1055	Phosphorylation	EFCARRNTFELITVR HHHHHCCEEEEEEEC	19.37	20873877
1079	Phosphorylation	LVSQCRDTLCVTKNW HHHHHHHHEEEECCC	11.60	63754861
1084	Acetylation	RDTLCVTKNWLSADT HHHEEEECCCCCCCC	26.23	26051181
1092	Sumoylation	NWLSADTKEERDLWM CCCCCCCHHHHHHHH	59.11	-
1092	Ubiquitination	NWLSADTKEERDLWM CCCCCCCHHHHHHHH	59.11	-
1101	Ubiquitination	ERDLWMQKLNQVLVD HHHHHHHHHHHHHHH	33.04	-
1118	Phosphorylation	LWQPDACYKPIGKP- CCCCCCCCCCCCCC-	22.86	21945579

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	ANAPC11	Q9NYG5	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	FZR1	Q9UM11	PMID:16040610

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ANLN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ANLN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MEN1_HUMAN	MEN1	physical	22939629
MARHA_HUMAN	MARCH10	physical	25416956
UBP2L_HUMAN	UBAP2L	physical	26344197
ZWILC_HUMAN	ZWILCH	physical	26344197
ACTG_HUMAN	ACTG1	physical	26496610
ACTN4_HUMAN	ACTN4	physical	26496610
ACTN1_HUMAN	ACTN1	physical	26496610
AP2A1_HUMAN	AP2A1	physical	26496610
AP2B1_HUMAN	AP2B1	physical	26496610
APOB_HUMAN	APOB	physical	26496610
BLMH_HUMAN	BLMH	physical	26496610
DYST_HUMAN	DST	physical	26496610
CALL3_HUMAN	CALML3	physical	26496610
KCC2G_HUMAN	CAMK2G	physical	26496610
CAZA1_HUMAN	CAPZA1	physical	26496610
CAZA2_HUMAN	CAPZA2	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
SEPT7_HUMAN	SEPT7	physical	26496610
COF1_HUMAN	CFL1	physical	26496610
AP2M1_HUMAN	AP2M1	physical	26496610
CLIC1_HUMAN	CLIC1	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
CLH1_HUMAN	CLTC	physical	26496610
CBPM_HUMAN	CPM	physical	26496610
DAB2_HUMAN	DAB2	physical	26496610
DREB_HUMAN	DBN1	physical	26496610
EF1D_HUMAN	EEF1D	physical	26496610
EPS15_HUMAN	EPS15	physical	26496610
FLII_HUMAN	FLII	physical	26496610
FLNA_HUMAN	FLNA	physical	26496610
FLNB_HUMAN	FLNB	physical	26496610
FYN_HUMAN	FYN	physical	26496610
GCR_HUMAN	NR3C1	physical	26496610
ITPR3_HUMAN	ITPR3	physical	26496610
ABLM1_HUMAN	ABLIM1	physical	26496610
LMO7_HUMAN	LMO7	physical	26496610
LYN_HUMAN	LYN	physical	26496610
MYO1B_HUMAN	MYO1B	physical	26496610
MYH9_HUMAN	MYH9	physical	26496610
MYL6_HUMAN	MYL6	physical	26496610
MYLK_HUMAN	MYLK	physical	26496610
MYO1C_HUMAN	MYO1C	physical	26496610
MYO1E_HUMAN	MYO1E	physical	26496610
MYO5A_HUMAN	MYO5A	physical	26496610
MYO5B_HUMAN	MYO5B	physical	26496610
MYO6_HUMAN	MYO6	physical	26496610
MYPT1_HUMAN	PPP1R12A	physical	26496610
MYPT2_HUMAN	PPP1R12B	physical	26496610
SEPT2_HUMAN	SEPT2	physical	26496610
P3C2A_HUMAN	PIK3C2A	physical	26496610
PLEC_HUMAN	PLEC	physical	26496610
PP1A_HUMAN	PPP1CA	physical	26496610
PP1B_HUMAN	PPP1CB	physical	26496610
TWF1_HUMAN	TWF1	physical	26496610
SIPA1_HUMAN	SIPA1	physical	26496610
FSCN1_HUMAN	FSCN1	physical	26496610
DHSO_HUMAN	SORD	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SPTB2_HUMAN	SPTBN1	physical	26496610
SSFA2_HUMAN	SSFA2	physical	26496610
ST5_HUMAN	ST5	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TCEA2_HUMAN	TCEA2	physical	26496610
TMOD1_HUMAN	TMOD1	physical	26496610
BACD2_HUMAN	TNFAIP1	physical	26496610
TPM1_HUMAN	TPM1	physical	26496610
TPM2_HUMAN	TPM2	physical	26496610
TPM3_HUMAN	TPM3	physical	26496610
TPM4_HUMAN	TPM4	physical	26496610
COR2A_HUMAN	CORO2A	physical	26496610
YES_HUMAN	YES1	physical	26496610
LUZP1_HUMAN	LUZP1	physical	26496610
PICAL_HUMAN	PICALM	physical	26496610
SRBS2_HUMAN	SORBS2	physical	26496610
NUMB_HUMAN	NUMB	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
RHGBA_HUMAN	ARHGAP11A	physical	26496610
ARHGH_HUMAN	ARHGEF17	physical	26496610
WDR1_HUMAN	WDR1	physical	26496610
ARPC5_HUMAN	ARPC5	physical	26496610
ARPC4_HUMAN	ARPC4	physical	26496610
ARPC3_HUMAN	ARPC3	physical	26496610
ARP3_HUMAN	ACTR3	physical	26496610
ARP2_HUMAN	ACTR2	physical	26496610
ARPC2_HUMAN	ARPC2	physical	26496610
BASP1_HUMAN	BASP1	physical	26496610
ML12A_HUMAN	MYL12A	physical	26496610
SEPT9_HUMAN	SEPT9	physical	26496610
TARA_HUMAN	TRIOBP	physical	26496610
CTRO_HUMAN	CIT	physical	26496610
AKAP2_HUMAN	AKAP2	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
CE162_HUMAN	CEP162	physical	26496610
AAK1_HUMAN	AAK1	physical	26496610
LIMC1_HUMAN	LIMCH1	physical	26496610
SEPT6_HUMAN	SEPT6	physical	26496610
MPRIP_HUMAN	MPRIP	physical	26496610
COBL_HUMAN	COBL	physical	26496610
CYTSA_HUMAN	SPECC1L	physical	26496610
COR1C_HUMAN	CORO1C	physical	26496610
INT7_HUMAN	INTS7	physical	26496610
PKHG3_HUMAN	PLEKHG3	physical	26496610
RAI14_HUMAN	RAI14	physical	26496610
TES_HUMAN	TES	physical	26496610
ZBT20_HUMAN	ZBTB20	physical	26496610
PACN3_HUMAN	PACSIN3	physical	26496610
TMOD3_HUMAN	TMOD3	physical	26496610
LIMA1_HUMAN	LIMA1	physical	26496610
GTSE1_HUMAN	GTSE1	physical	26496610
RM16_HUMAN	MRPL16	physical	26496610
UACA_HUMAN	UACA	physical	26496610
ELP3_HUMAN	ELP3	physical	26496610
FEM1A_HUMAN	FEM1A	physical	26496610
BMP2K_HUMAN	BMP2K	physical	26496610
MYO5C_HUMAN	MYO5C	physical	26496610
COR1B_HUMAN	CORO1B	physical	26496610
MICA3_HUMAN	MICAL3	physical	26496610
RHG21_HUMAN	ARHGAP21	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
INF2_HUMAN	INF2	physical	26496610
RM38_HUMAN	MRPL38	physical	26496610
MYO19_HUMAN	MYO19	physical	26496610
ARP5L_HUMAN	ARPC5L	physical	26496610
STON2_HUMAN	STON2	physical	26496610
SSH2_HUMAN	SSH2	physical	26496610
NEXN_HUMAN	NEXN	physical	26496610
CYTSB_HUMAN	SPECC1	physical	26496610
MISP_HUMAN	MISP	physical	26496610
MYL6B_HUMAN	MYL6B	physical	26496610
SEP10_HUMAN	SEPT10	physical	26496610
TPRN_HUMAN	TPRN	physical	26496610
MY18A_HUMAN	MYO18A	physical	26496610
RHOA_HUMAN	RHOA	physical	25959226

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616032	Focal segmental glomerulosclerosis 8 (FSGS8)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ANLN_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-371, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54; SER-323 AND SER-485,AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54; SER-323 AND SER-449,AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54; SER-72; SER-99;SER-102; SER-172; THR-320; SER-323; THR-364; THR-393; THR-397;THR-401; SER-449; SER-485; SER-518; SER-553; SER-658; SER-661;SER-664; SER-792 AND SER-927, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97; SER-102 AND SER-661,AND MASS SPECTROMETRY.	18220336 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182; THR-194; SER-362;THR-368; SER-449 AND SER-927, AND MASS SPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-194; THR-320; SER-323;THR-401; SER-449 AND SER-485, AND MASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-637, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99; SER-323 AND SER-485,AND MASS SPECTROMETRY.	15302935 [Abstract]