FEM1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FEM1A_HUMAN
• UniProt AC: Q9BSK4
• Protein Name: Protein fem-1 homolog A
• Gene Name: FEM1A
• Organism: Homo sapiens (Human).
• Sequence Length: 669
• Subcellular Localization: Cytoplasm .
• Protein Description: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory signaling via its interaction with PTGER4..
• Protein Sequence: MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGEYLPKPEPPQLVLAYDYSREVNTTEELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERALQLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNALIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPEDLEAFIELH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Ubiquitination	YNAARDGKLQLLQKL HHHHHHCHHHHHHHH	37.03	29967540
21	Ubiquitination	GKLQLLQKLLSGRSR CHHHHHHHHHCCCCH	51.90	21906983
24	Phosphorylation	QLLQKLLSGRSREEL HHHHHHHCCCCHHHH	42.47	25404012
27	Phosphorylation	QKLLSGRSREELDEL HHHHCCCCHHHHHHH	47.79	25404012
108	Phosphorylation	SLLRRGASVNRTTRT HHHHCCCCCCCCCCC	23.81	29759185
112	Phosphorylation	RGASVNRTTRTNSTP CCCCCCCCCCCCCCC	18.54	29759185
113	Phosphorylation	GASVNRTTRTNSTPL CCCCCCCCCCCCCCC	32.05	29759185
115	Phosphorylation	SVNRTTRTNSTPLRA CCCCCCCCCCCCCCH	31.28	25106551
117	Phosphorylation	NRTTRTNSTPLRAAC CCCCCCCCCCCCHHH	30.68	24719451
182	Ubiquitination	QVNRRSAKGNTALHD CCCCCCCCCCCHHHC	54.67	-
206	Ubiquitination	LQLLLGCKARMERDG HHHHHHCCCCCCCCC	36.91	-
311	Ubiquitination	LGATYVDKKRDLLGA HCCCCCCHHHHHHHH	39.40	29967540
312	Ubiquitination	GATYVDKKRDLLGAL CCCCCCHHHHHHHHH	46.83	-
320	Ubiquitination	RDLLGALKHWRRAME HHHHHHHHHHHHHHH	40.36	21906983
385	Phosphorylation	RERILGPSHPDTSYY HHHHHCCCCCCCCEE	45.94	-
452	Ubiquitination	VLQDRAAKGSLGTQI HHHHHHHCCCCCHHH	48.31	-
470	Ubiquitination	DLMGVLTKGVREVER HHHHHHHHHHHHHHH	51.77	-
488	Phosphorylation	LPREPGDSAQFTKAL CCCCCCCHHHHHHHH	29.86	25159151
513	Phosphorylation	EKVECTPSQEHLKHQ HHCCCCCCHHHHCHH	30.01	24825855
518	Ubiquitination	TPSQEHLKHQTVYRL CCCHHHHCHHHHHHH	35.26	29967540
527	Ubiquitination	QTVYRLLKCAPRGKN HHHHHHHHCCCCCCC	32.70	27667366
547	Phosphorylation	HMAVDKDTTNVGRYP EEEECCCCCCCCCCC	26.47	29759185
548	Phosphorylation	MAVDKDTTNVGRYPV EEECCCCCCCCCCCC	37.73	29759185
553	Phosphorylation	DTTNVGRYPVGRFPS CCCCCCCCCCCCCCC	9.06	29759185
560	Phosphorylation	YPVGRFPSLHVVKVL CCCCCCCCHHHHHHH	28.53	25247763
615	Ubiquitination	DATNAFKKTAYELLD CCCHHHHHHHHHHHC	31.75	29967540
624	Ubiquitination	AYELLDEKLLARGTM HHHHHCHHHHHCCCC	48.76	22817900
624	Acetylation	AYELLDEKLLARGTM HHHHHCHHHHHCCCC	48.76	24848999
649	Ubiquitination	LAARALDKNKIPYKG HHHHHHCCCCCCCCC	62.07	23503661
651	Ubiquitination	ARALDKNKIPYKGFI HHHHCCCCCCCCCCC	51.29	21963094
655	Ubiquitination	DKNKIPYKGFIPEDL CCCCCCCCCCCCHHH	41.83	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FEM1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FEM1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FEM1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PE2R4_HUMAN	PTGER4	physical	16424369

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.