PE2R4_HUMAN - dbPTM
PE2R4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PE2R4_HUMAN
UniProt AC P35408
Protein Name Prostaglandin E2 receptor EP4 subtype
Gene Name PTGER4
Organism Homo sapiens (Human).
Sequence Length 488
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function..
Protein Sequence MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSTPGVNSS
------CCCCCCCCC		43.2225002506
3Phosphorylation-----MSTPGVNSSA
-----CCCCCCCCCC		23.8225002506
7N-linked_Glycosylation-MSTPGVNSSASLSP
-CCCCCCCCCCCCCH		35.84UniProtKB CARBOHYD
8PhosphorylationMSTPGVNSSASLSPD
CCCCCCCCCCCCCHH		25.5225002506
221PhosphorylationHRQFMRRTSLGTEQH
HHHHHHHHCCCCHHH		20.2426307563
222PhosphorylationRQFMRRTSLGTEQHH
HHHHHHHCCCCHHHH		24.0026307563
225PhosphorylationMRRTSLGTEQHHAAA
HHHHCCCCHHHHHHH		37.4526657352
235PhosphorylationHHAAAAASVASRGHP
HHHHHHHHHHHCCCC		17.3128060719
238PhosphorylationAAAASVASRGHPAAS
HHHHHHHHCCCCCCC		36.3227080861
245PhosphorylationSRGHPAASPALPRLS
HCCCCCCCCCCCCHH		16.8928450419
252PhosphorylationSPALPRLSDFRRRRS
CCCCCCHHHHHHHHH		35.6628270605
259PhosphorylationSDFRRRRSFRRIAGA
HHHHHHHHHHHHCHH		22.6911597569
308UbiquitinationSLEREVSKNPDLQAI
HHHHHHCCCCCHHHH		77.12-
335PhosphorylationIYILLRKTVLSKAIE
HHHHHHHHHHHHHHH		21.90-
338PhosphorylationLLRKTVLSKAIEKIK
HHHHHHHHHHHHHHH		18.72-
354PhosphorylationLFCRIGGSRRERSGQ
EEEECCCCCCCCCCC		23.9711597569
370PhosphorylationCSDSQRTSSAMSGHS
CCCCHHHHHHHCHHC		20.4923532336
374PhosphorylationQRTSSAMSGHSRSFI
HHHHHHHCHHCHHHH		32.8214709160
377PhosphorylationSSAMSGHSRSFISRE
HHHHCHHCHHHHHHH		32.9014709160
379PhosphorylationAMSGHSRSFISRELK
HHCHHCHHHHHHHHH		29.9114709160
382PhosphorylationGHSRSFISRELKEIS
HHCHHHHHHHHHHHH		20.0714709160
389PhosphorylationSRELKEISSTSQTLL
HHHHHHHHCCCCCCC		28.7630278072
390PhosphorylationRELKEISSTSQTLLP
HHHHHHHCCCCCCCC		37.4328634120
391PhosphorylationELKEISSTSQTLLPD
HHHHHHCCCCCCCCC		20.3328634120
392PhosphorylationLKEISSTSQTLLPDL
HHHHHCCCCCCCCCC		24.1028634120
394PhosphorylationEISSTSQTLLPDLSL
HHHCCCCCCCCCCCC		29.9926657352
400PhosphorylationQTLLPDLSLPDLSEN
CCCCCCCCCCCCCCC		45.2828634120
428PhosphorylationMGLAQEDTTSLRTLR
CCCCCCCCCCCEEEE		19.9624850871
429PhosphorylationGLAQEDTTSLRTLRI
CCCCCCCCCCEEEEE		37.7828348404
430PhosphorylationLAQEDTTSLRTLRIS
CCCCCCCCCEEEEEE		20.2511597569
433PhosphorylationEDTTSLRTLRISETS
CCCCCCEEEEEEECC		26.1911597569
460PhosphorylationLVDEAGGSGRAGPAP
EEECCCCCCCCCCCC		24.9611597569
468UbiquitinationGRAGPAPKGSSLQVT
CCCCCCCCCCCEEEE		73.8021890473
484PhosphorylationPSETLNLSEKCI---
CHHHCCCCHHCC---		33.6611597569
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
222SPhosphorylationKinasePKA-FAMILY-GPS
222SPhosphorylationKinasePKA_GROUP-PhosphoELM
259SPhosphorylationKinasePKA-FAMILY-GPS
259SPhosphorylationKinasePKC-FAMILY-GPS
259SPhosphorylationKinasePKA_GROUP-PhosphoELM
259SPhosphorylationKinasePKC_GROUP-PhosphoELM
354SPhosphorylationKinasePKC-FAMILY-GPS
354SPhosphorylationKinasePKC_GROUP-PhosphoELM
430SPhosphorylationKinasePKC-FAMILY-GPS
430SPhosphorylationKinasePKC_GROUP-PhosphoELM
433TPhosphorylationKinasePKC-FAMILY-GPS
433TPhosphorylationKinasePKC_GROUP-PhosphoELM
460SPhosphorylationKinasePKC-FAMILY-GPS
460SPhosphorylationKinasePKC_GROUP-PhosphoELM
484SPhosphorylationKinasePKC-FAMILY-GPS
484SPhosphorylationKinasePKC_GROUP-PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PE2R4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PE2R4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FEM1A_HUMANFEM1Aphysical
16424369
PSN1_HUMANPSEN1physical
19407341
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PE2R4_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory