TNPO3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNPO3_MOUSE
• UniProt AC: Q6P2B1
• Protein Name: Transportin-3
• Gene Name: Tnpo3
• Organism: Mus musculus (Mouse).
• Sequence Length: 923
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains (By similarity)..
• Protein Sequence: MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHSIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVHLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNGLLEIAHSLDSFMLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANSSVMRFLRDLIHTGVANDHEEDFELRKELIGQVMSQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHKQVTSAEECKQVCWALRDFTRLFR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGAKPTL -------CCCCCCHH	10.93	-
5	Acetylation	---MEGAKPTLQLVY ---CCCCCCHHHHHH	49.76	22733758
27	Ubiquitination	HDPDPSGKERASFWL CCCCCCCCHHHHHHH	48.65	-
68	Ubiquitination	YFAAQTMKMKIQTSF HHHHHHHHHHHEECE	40.19	22790023
68 (in isoform 2)	Ubiquitination	-	40.19	22790023
74	Phosphorylation	MKMKIQTSFYELPTD HHHHHEECEECCCCC	14.95	-
125	S-nitrosocysteine	QMPSWKGCVQTLVEK CCCCHHHHHHHHHHH	1.49	-
125	S-nitrosylation	QMPSWKGCVQTLVEK CCCCHHHHHHHHHHH	1.49	20925432
242 (in isoform 3)	Phosphorylation	-	27.22	15345747
291	Ubiquitination	VAREDLDKVLNYCRI HHHHHHHHHHHHHHH	56.79	-
312	S-palmitoylation	TFLEKIVCTPGQGLG HHHHHCCCCCCCCCC	4.29	28526873
513 (in isoform 2)	Ubiquitination	-	44.31	22790023
513	Ubiquitination	LMKGLCEKPLASAAA HHHCCCCCHHHHHHH	44.31	22790023
594	Ubiquitination	VQVMALKKLLSQEPS HHHHHHHHHHCCCCC	56.35	-
875	Phosphorylation	FCRWLENSLKGLPKE HHHHHHHHCCCCCCC	23.29	22345495
877	Ubiquitination	RWLENSLKGLPKETT HHHHHHCCCCCCCCC	59.22	-
883	Phosphorylation	LKGLPKETTVGAVTV CCCCCCCCCCCEEEE	32.67	22345495
884	Phosphorylation	KGLPKETTVGAVTVT CCCCCCCCCCEEEEE	20.31	22345495
889	Phosphorylation	ETTVGAVTVTHKQLT CCCCCEEEEEHHHHH	21.10	22345495
891	Phosphorylation	TVGAVTVTHKQLTDF CCCEEEEEHHHHHHH	17.62	22345495
896	Phosphorylation	TVTHKQLTDFHKQVT EEEHHHHHHHHHHCC	33.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNPO3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNPO3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNPO3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TNPO3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.