CSN3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSN3_MOUSE
• UniProt AC: O88543
• Protein Name: COP9 signalosome complex subunit 3
• Gene Name: Cops3
• Organism: Mus musculus (Mouse).
• Sequence Length: 423
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo..
• Protein Sequence: MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSVHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVSKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASALEQFV ------CHHHHHHHH	11.96	-
3	Phosphorylation	-----MASALEQFVN -----CHHHHHHHHH	31.89	25293948
16	Phosphorylation	VNSVRQLSAQGQMTQ HHHHHHHHHHCCHHH	15.37	26745281
22	Phosphorylation	LSAQGQMTQLCELIN HHHHCCHHHHHHHHH	15.53	27566939
30	Ubiquitination	QLCELINKSGELLAK HHHHHHHHHHHHHHH	53.49	-
31	Phosphorylation	LCELINKSGELLAKN HHHHHHHHHHHHHHH	32.77	18779572
125	Ubiquitination	LRGIGILKQAIDKMQ CCHHHHHHHHHHHHC	35.44	22790023
125	Acetylation	LRGIGILKQAIDKMQ CCHHHHHHHHHHHHC	35.44	22826441
171	Ubiquitination	VDMMDICKENGAYDA CCHHHHHHHCCCCCC	55.32	22790023
176	Phosphorylation	ICKENGAYDAKHFLC HHHHCCCCCCHHHHH	20.17	21659604
243	Ubiquitination	GKVQQLPKYTSQIVG HHHHHCCHHHHHHHH	70.52	-
281	Acetylation	ELRNLVSKHSETFTR HHHHHHHHCCCCCCC	43.61	22826441
281	Ubiquitination	ELRNLVSKHSETFTR HHHHHHHHCCCCCCC	43.61	22790023
312	Ubiquitination	KNIQRLTKTFLTLSL HHHHHHHHHHHHHHH	41.70	22790023
366	Ubiquitination	SFHDNPEKYNNPAML ECCCCHHHCCCHHHH	55.31	22790023
391	Ubiquitination	IELDERLKAMDQEIT HHHHHHHHHHCCCCC	48.13	22790023
407	Phosphorylation	NPQFVQKSMGSQEDD CHHHHHHHCCCCCCC	15.98	23984901
410	Phosphorylation	FVQKSMGSQEDDSGN HHHHHCCCCCCCCCC	23.04	25521595
415	Phosphorylation	MGSQEDDSGNKPSSY CCCCCCCCCCCCCCC	57.50	25619855
418	Ubiquitination	QEDDSGNKPSSYS-- CCCCCCCCCCCCC--	50.21	-
420	Phosphorylation	DDSGNKPSSYS---- CCCCCCCCCCC----	43.44	25619855
421	Phosphorylation	DSGNKPSSYS----- CCCCCCCCCC-----	37.61	25619855
422	Phosphorylation	SGNKPSSYS------ CCCCCCCCC------	23.80	25619855
423	Phosphorylation	GNKPSSYS------- CCCCCCCC-------	35.38	23684622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
410	S	Phosphorylation	Kinase	ATM	Q13315	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSN3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSN3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CSN3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.