STOM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STOM_MOUSE
• UniProt AC: P54116
• Protein Name: Erythrocyte band 7 integral membrane protein
• Gene Name: Stom
• Organism: Mus musculus (Mouse).
• Sequence Length: 284
• Subcellular Localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cell membrane ; Lipid-anchor ; Cytoplasmic side . Membrane raft . Melanosome . Cytoplasmic vesicle . Localizes to juxtanuclear structure probably derived from
• Protein Description: Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity..
• Protein Sequence: MSDKRQSSHVQSQRIPESFRENSKTELGACGWILVAASFFFVIITFPISIWICIKIVKEYERVIIFRLGRILQGGAKGPGLFFILPCTDSLIKVDMRTISFDIPPQEVLTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNALGTKNLSQILSDREEIAHHMQSTLDDATDDWGIKVERVEIKDVKLPVQLQRAMAAEAEAAREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPVDMLQGIMGSNH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDKRQSSH ------CCHHHHHHH	52.41	23684622
7	Phosphorylation	-MSDKRQSSHVQSQR -CCHHHHHHHHHHHH	26.83	26824392
8	Phosphorylation	MSDKRQSSHVQSQRI CCHHHHHHHHHHHHC	21.24	23737553
12	Phosphorylation	RQSSHVQSQRIPESF HHHHHHHHHHCCHHH	21.97	26060331
18	Phosphorylation	QSQRIPESFRENSKT HHHHCCHHHHHCCCC	25.01	19144319
30	S-palmitoylation	SKTELGACGWILVAA CCCCHHHHHHHHHHH	4.38	-
87	S-palmitoylation	GLFFILPCTDSLIKV CEEEEEECCCCEEEC	6.22	28526873
87	Glutathionylation	GLFFILPCTDSLIKV CEEEEEECCCCEEEC	6.22	24333276
100	Phosphorylation	KVDMRTISFDIPPQE ECCCCEEEECCCCHH	19.09	-
130	Phosphorylation	YYRVQNATLAVANIT EEEEECCEEEEEECC	23.85	22942356
137	Phosphorylation	TLAVANITNADSATR EEEEEECCCCHHHHH	24.94	29472430
141	Phosphorylation	ANITNADSATRLLAQ EECCCCHHHHHHHHH	29.18	29472430
143	Phosphorylation	ITNADSATRLLAQTT CCCCHHHHHHHHHHH	26.29	29472430
161	Phosphorylation	ALGTKNLSQILSDRE HHCCCCHHHHHCCHH	25.27	26824392
165	Phosphorylation	KNLSQILSDREEIAH CCHHHHHCCHHHHHH	35.93	23984901
176	Phosphorylation	EIAHHMQSTLDDATD HHHHHHHHHHHHHCC	24.30	23984901
177	Phosphorylation	IAHHMQSTLDDATDD HHHHHHHHHHHHCCC	19.81	23984901
198	Ubiquitination	RVEIKDVKLPVQLQR EEEEECCCCCHHHHH	58.15	-
220	Ubiquitination	AAREARAKVIAAEGE HHHHHHHHHHHHHHC	28.72	-
235	Ubiquitination	MNASRALKEASMVIT CCHHHHHHHHCEEEE	50.69	-
242	Phosphorylation	KEASMVITESPAALQ HHHCEEEECCCHHHH	20.99	28066266
244	Phosphorylation	ASMVITESPAALQLR HCEEEECCCHHHHHH	15.93	19144319
252	Phosphorylation	PAALQLRYLQTLTTI CHHHHHHHHHHHHHH	16.26	29514104
265	Phosphorylation	TIAAEKNSTIVFPLP HHHHHCCCEEEEECC	30.49	23649490

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STOM_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STOM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STOM_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of STOM_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161 AND SER-244, ANDMASS SPECTROMETRY.
PubMed: 19144319