U2AF1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: U2AF1_MOUSE
• UniProt AC: Q9D883
• Protein Name: Splicing factor U2AF 35 kDa subunit
• Gene Name: U2af1
• Organism: Mus musculus (Mouse).
• Sequence Length: 239
• Subcellular Localization: Nucleus . Nucleus speckle .
• Protein Description: Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity)..
• Protein Sequence: MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQSADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRELRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGRERDRRRSRDRERSGRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEYLASIF ------CHHHHHHHH	17.72	-
4	Phosphorylation	----MAEYLASIFGT ----CHHHHHHHHCC	9.68	29514104
7	Phosphorylation	-MAEYLASIFGTEKD -CHHHHHHHHCCCCC	18.82	29514104
11	Phosphorylation	YLASIFGTEKDKVNC HHHHHHCCCCCCCCC	29.16	19854140
13	Ubiquitination	ASIFGTEKDKVNCSF HHHHCCCCCCCCCEE	63.79	-
19	Phosphorylation	EKDKVNCSFYFKIGA CCCCCCCEEEEEECC	20.13	25266776
21	Phosphorylation	DKVNCSFYFKIGACR CCCCCEEEEEECCCC	6.41	28066266
39	Methylation	RCSRLHNKPTFSQTI HHHHHCCCCCHHHHH	34.39	-
58	Phosphorylation	IYRNPQNSSQSADGL HHCCCCCCCCCCCCC	25.22	25159016
59	Phosphorylation	YRNPQNSSQSADGLR HCCCCCCCCCCCCCE	35.39	25159016
61	Phosphorylation	NPQNSSQSADGLRCA CCCCCCCCCCCCEEC	30.21	26824392
93	Phosphorylation	FTEMEEKYGEVEEMN HHHHHHHHCCCEEEE	23.07	-
145	Phosphorylation	QPIHAELSPVTDFRE CCCEEECCCCCCHHH	14.61	19854140
165	Methylation	YEMGECTRGGFCNFM HHCCCCCCCCCCCCE	55.70	30761483
169	S-nitrosylation	ECTRGGFCNFMHLKP CCCCCCCCCCEECCC	4.31	20925432
169	S-nitrosocysteine	ECTRGGFCNFMHLKP CCCCCCCCCCEECCC	4.31	-
230	Phosphorylation	RERDRRRSRDRERSG HHHHHHHHCHHHHHC	36.40	-
236	Phosphorylation	RSRDRERSGRF---- HHCHHHHHCCC----	29.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of U2AF1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of U2AF1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of U2AF1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of U2AF1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.