RBM19_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBM19_MOUSE
• UniProt AC: Q8R3C6
• Protein Name: Probable RNA-binding protein 19
• Gene Name: Rbm19
• Organism: Mus musculus (Mouse).
• Sequence Length: 952
• Subcellular Localization: Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Chromosome. Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to nucleolar precursor bod
• Protein Description: Plays a role in embryo pre-implantation development..
• Protein Sequence: MSRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQAALNHFHRSFIDTTRITVEFCKSFGDPSKPRAWSKHAQKSSQPKQPSQDSVPSDTKKDKKKKGPSDLEKLKEDAKFQEFLSIHQKRTQVATWANDALEAKLPKAKTKASSDYLNFDSDSNSDSGQESEEEPAREDPEEEQGLQPKAAVQKELSDMDYLKSKMVRAEVSSEDEDEEDSEDEAVNCEEGSEEEEEEGSPASPAKQGGVSRGAVPGVLRPQEAAGKVEKPVSQKEPTTPYTVKLRGAPFNVTEKNVIEFLAPLKPVAIRIVRNAHGNKTGYVFVDLSSEEEVKKALKCNRDYMGGRYIEVFREKQAPTARGPPKSTTPWQGRTLGENEEEEDLADSGRLFVRNLSYTSSEEDLEKLFSAYGPLSELHYPIDSLTKKPKGFAFVTFMFPEHAVKAYAEVDGQVFQGRMLHVLPSTIKKEASQEANAPGSSYKKKKEAMDKANSSSSHNWNTLFMGPNAVADAIAQKYNATKSQVFDHETRGSVAVRVALGETQLVQEVRSFLIDNGVCLDSFSQAAAERSKTVILAKNLPAGTLAAEIQETFSRFGSLGRVLLPEGGITAIVEFLEPLEARKAFRHLAYSKFHHVPLYLEWAPIGVFGAAPQKKDSQHEQPAEKAEVEQETVLDPEGEKASVEGAEASTGKMEEEEEEEEEEEEESIPGCTLFIKNLNFSTTEETLKGVFSKVGAIKSCTISKKKNKAGVLLSMGFGFVEYKKPEQAQKALKQLQGHTVDGHKLEVRISERATKPALTSTRKKQVPKKQTTSKILVRNIPFQANQREIRELFSTFGELKTVRLPKKMTGTGAHRGFGFVDFITKQDAKKAFNALCHSTHLYGRRLVLEWADSEVTVQTLRRKTARHFQEPPKKKRSAVLDGILEQLEDEDNSDGEQALQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
177	Phosphorylation	NFDSDSNSDSGQESE CCCCCCCCCCCCCCC	36.79	-
179	Phosphorylation	DSDSNSDSGQESEEE CCCCCCCCCCCCCCC	42.04	-
183	Phosphorylation	NSDSGQESEEEPARE CCCCCCCCCCCCCCC	42.28	-
279	Acetylation	RPQEAAGKVEKPVSQ CHHHHCCCCCCCCCC	42.36	6565917
282	Acetylation	EAAGKVEKPVSQKEP HHCCCCCCCCCCCCC	54.42	6565953
287	Acetylation	VEKPVSQKEPTTPYT CCCCCCCCCCCCCEE	59.14	6566187
290	Phosphorylation	PVSQKEPTTPYTVKL CCCCCCCCCCEEEEE	41.30	25338131
332	Phosphorylation	RNAHGNKTGYVFVDL ECCCCCCCEEEEEEC	37.43	30635358
334	Phosphorylation	AHGNKTGYVFVDLSS CCCCCCEEEEEECCC	8.92	30635358
340	Phosphorylation	GYVFVDLSSEEEVKK EEEEEECCCHHHHHH	31.10	30635358
341	Phosphorylation	YVFVDLSSEEEVKKA EEEEECCCHHHHHHH	57.22	30635358
408	Phosphorylation	RLFVRNLSYTSSEED CEEEEECCCCCCHHH	29.88	25159016
409	Phosphorylation	LFVRNLSYTSSEEDL EEEEECCCCCCHHHH	17.51	25159016
410	Phosphorylation	FVRNLSYTSSEEDLE EEEECCCCCCHHHHH	23.54	25159016
483	Phosphorylation	STIKKEASQEANAPG HHHHHHHHHHCCCCC	29.64	27841257
668	Phosphorylation	AAPQKKDSQHEQPAE CCCCCCCCCCCCCHH	42.17	28059163
683	Phosphorylation	KAEVEQETVLDPEGE HHHHEEEEECCCCCC	26.51	28285833
693	Phosphorylation	DPEGEKASVEGAEAS CCCCCCCCCCCHHHH	31.59	26824392
700	Phosphorylation	SVEGAEASTGKMEEE CCCCHHHHCCCCCHH	29.24	25619855
701	Phosphorylation	VEGAEASTGKMEEEE CCCHHHHCCCCCHHH	48.12	25619855
876	Ubiquitination	GFVDFITKQDAKKAF CHHEEECHHHHHHHH	41.17	-
880	Ubiquitination	FITKQDAKKAFNALC EECHHHHHHHHHHHH	53.58	-
928	Phosphorylation	EPPKKKRSAVLDGIL CCCCHHHHHHHHHHH	31.44	27087446
944	Phosphorylation	QLEDEDNSDGEQALQ HHHCCCCCCCCHHHC	60.35	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RBM19_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBM19_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBM19_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RBM19_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-944, AND MASSSPECTROMETRY.
PubMed: 19144319