MYO1E_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO1E_MOUSE
• UniProt AC: E9Q634
• Protein Name: Unconventional myosin-Ie
• Gene Name: Myo1e
• Organism: Mus musculus (Mouse).
• Sequence Length: 1107
• Subcellular Localization: Cytoplasm . Cell junction . Cytoplasmic vesicle . Cytoplasmic vesicle, clathrin-coated vesicle . Cytoplasm, cytoskeleton . In podocytes, it localizes close to and is associated with the cytoplasmic membrane, with enrichment at the lamellipodia tips.
• Protein Description: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain (By similarity). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14 (By similarity)..
• Protein Sequence: MGSKGAYRYHWQSHNVKHSGVDDMVLLSKITESSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEVEMYQGAAQYENPPHIYALADSMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYVSRVSGGGPKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASPEQKQSLGITSMDYYYYLSLSGSYKVDDIDDKRDFQETLHAMNVIGIFSEEQTLVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIESKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATWPVWRGDEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKTWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEERPELQQFVGKREKIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGVVKEVLKRRIEVERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFHQGFGDLAILKPSNKVLQVSIGPGLPKNSRPTRRNTVTSRGYPGGTKNNYPMRAAPAPPGCHQNGVIRNQFVPPPHAFGNQRSNQKSLYTSMARPPLPRQQSTGSDRLSQTPESLDFLKVPDQGVAGVRRQTSSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	GSKGAYRYHWQSHNV CCCCCCHHHCCCCCC	8.50	25367039
43	Phosphorylation	VENLKKRYMDDYIFT HHHHHHHHCCHHHHH	17.49	20469934
47	Phosphorylation	KKRYMDDYIFTYIGS HHHHCCHHHHHHCCC	8.15	20469934
50	Phosphorylation	YMDDYIFTYIGSVLI HCCHHHHHHCCCEEE	12.50	20469934
51	Phosphorylation	MDDYIFTYIGSVLIS CCHHHHHHCCCEEEE	7.79	20469934
54	Phosphorylation	YIFTYIGSVLISVNP HHHHHCCCEEEECCC	12.28	20469934
58	Phosphorylation	YIGSVLISVNPFKQM HCCCEEEECCCCCCC	16.22	20469934
124	Phosphorylation	GKTVAAKYIMSYVSR CHHHHHHHHHHHHHH	9.34	30165576
127	Phosphorylation	VAAKYIMSYVSRVSG HHHHHHHHHHHHHCC	16.90	30165576
128	Phosphorylation	AAKYIMSYVSRVSGG HHHHHHHHHHHHCCC	5.76	30165576
160	Ubiquitination	LEAFGNAKTVRNNNS HHHHCCCEEECCCCC	52.10	22790023
196	Ubiquitination	ISNFLLEKSRVVMRN CCCHHHEECEEEEEC	43.46	22790023
554	Ubiquitination	PENLQADKKGRPTTA CCCCCCCCCCCCCCC	61.21	22790023
574	Phosphorylation	KQANDLVSTLMKCTP HHHHHHHHHHHHHCH	24.11	28978645
583	Phosphorylation	LMKCTPHYIRCIKPN HHHHCHHHHCCCCCC	7.40	28978645
613	Ubiquitination	QVEYLGLKENIRVRR HHHHCCCHHCHHHHH	47.09	22790023
695	Phosphorylation	EEMRERKYDGYARVI HHHHHCCCCCHHHHH	22.33	25367039
698	Phosphorylation	RERKYDGYARVIQKT HHCCCCCHHHHHHHH	6.58	25367039
736	Phosphorylation	KKERRRNSINRNFIG HHHHHHHHCCHHHHH	21.30	26824392
760	Ubiquitination	ELQQFVGKREKIDFA HHHHHHCCHHHCCHH	52.67	22790023
772	Ubiquitination	DFADTVTKYDRRFKG CHHHHCHHHHHHCCC	40.60	22790023
876	Phosphorylation	LPLKFSNTLELKLKK CCCCCCCCEEEEEEC	22.02	22942356
914	Ubiquitination	AILKPSNKVLQVSIG EEECCCCCEEEEEEC	48.97	22790023
919	Phosphorylation	SNKVLQVSIGPGLPK CCCEEEEEECCCCCC	14.63	22942356
935	Phosphorylation	SRPTRRNTVTSRGYP CCCCCCCCCCCCCCC	24.29	-
938	Phosphorylation	TRRNTVTSRGYPGGT CCCCCCCCCCCCCCC	21.26	25338131
941	Phosphorylation	NTVTSRGYPGGTKNN CCCCCCCCCCCCCCC	9.52	29514104
949	Phosphorylation	PGGTKNNYPMRAAPA CCCCCCCCCCCCCCC	14.06	29514104
986	Phosphorylation	NQRSNQKSLYTSMAR CCCCCCCCHHHHCCC	19.49	22499769
988	Phosphorylation	RSNQKSLYTSMARPP CCCCCCHHHHCCCCC	12.12	22499769
989	Phosphorylation	SNQKSLYTSMARPPL CCCCCHHHHCCCCCC	19.81	22499769
990	Phosphorylation	NQKSLYTSMARPPLP CCCCHHHHCCCCCCC	9.26	22499769
1001	Phosphorylation	PPLPRQQSTGSDRLS CCCCCCCCCCCCCCC	26.79	25521595
1002	Phosphorylation	PLPRQQSTGSDRLSQ CCCCCCCCCCCCCCC	36.05	22942356
1004	Phosphorylation	PRQQSTGSDRLSQTP CCCCCCCCCCCCCCC	21.46	26824392
1008	Phosphorylation	STGSDRLSQTPESLD CCCCCCCCCCCCCCC	32.66	26824392
1010	Phosphorylation	GSDRLSQTPESLDFL CCCCCCCCCCCCCCC	26.16	24453211
1013	Phosphorylation	RLSQTPESLDFLKVP CCCCCCCCCCCCCCC	34.15	23608596

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO1E_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO1E_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO1E_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MYO1E_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.