LIMS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIMS1_MOUSE
• UniProt AC: Q99JW4
• Protein Name: LIM and senescent cell antigen-like-containing domain protein 1
• Gene Name: Lims1
• Organism: Mus musculus (Mouse).
• Sequence Length: 325
• Subcellular Localization: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
• Protein Description: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation..
• Protein Sequence: MANALASATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVSCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEKFPLELKKRLKKLSETLGRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MANALASAT ------CCHHHHHHH	15.25	-
94	S-nitrosocysteine	NNSWHPECFRCDLCQ HCCCCHHHHCCHHHH	2.84	-
94	S-nitrosylation	NNSWHPECFRCDLCQ HCCCCHHHHCCHHHH	2.84	21278135
94	S-palmitoylation	NNSWHPECFRCDLCQ HCCCCHHHHCCHHHH	2.84	28526873
222	S-nitrosocysteine	EHFVCAKCEKPFLGH EEEEEECCCCCCCCC	4.29	-
222	S-nitrosylation	EHFVCAKCEKPFLGH EEEEEECCCCCCCCC	4.29	21278135
244	Phosphorylation	LAYCETHYNQLFGDV CHHHHHHHHHHHCCH	16.42	-
265	Phosphorylation	VIEGDVVSALNKAWC CCCCCHHHHCHHHHH	27.21	26824392
297	Acetylation	KFVEFDMKPVCKKCY CCEECCCHHHHHHHH	35.82	22826441
300	S-palmitoylation	EFDMKPVCKKCYEKF ECCCHHHHHHHHHHC	4.77	28526873
319	Phosphorylation	KKRLKKLSETLGRK- HHHHHHHHHHHCCC-	37.10	25266776
321	Phosphorylation	RLKKLSETLGRK--- HHHHHHHHHCCC---	31.01	24899341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIMS1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIMS1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIMS1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ILK_MOUSE	Ilk	physical	12432066

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.