CSRP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSRP2_MOUSE
• UniProt AC: P97314
• Protein Name: Cysteine and glycine-rich protein 2
• Gene Name: Csrp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 193
• Subcellular Localization: Nucleus.
• Protein Description: Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system (By similarity)..
• Protein Sequence: MPVWGGGNKCGACGRTVYHAEEVQCDGRSFHRCCFLCMVCRKNLDSTTVAIHDEEIYCKSCYGKKYGPKGYGYGQGAGTLNMDRGERLGIKPESAQPHRPTTNPNTSKFAQKYGGAEKCSRCGDSVYAAEKIIGAGKPWHKNCFRCAKCGKSLESTTLTEKEGEIYCKGCYAKNFGPKGFGYGQGAGALVHAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	S-nitrosocysteine	YHAEEVQCDGRSFHR EEEEEEECCCCCHHH	7.86	-
25	S-nitrosylation	YHAEEVQCDGRSFHR EEEEEEECCCCCHHH	7.86	21278135
57	Phosphorylation	AIHDEEIYCKSCYGK EECCCEEEECCCCCC	9.34	26060331
69	Ubiquitination	YGKKYGPKGYGYGQG CCCCCCCCCCCCCCC	61.47	-
71	Phosphorylation	KKYGPKGYGYGQGAG CCCCCCCCCCCCCCC	17.19	25195567
73	Phosphorylation	YGPKGYGYGQGAGTL CCCCCCCCCCCCCEE	9.59	25195567
79	Phosphorylation	GYGQGAGTLNMDRGE CCCCCCCEECCCCCC	17.90	29514104
91	Ubiquitination	RGERLGIKPESAQPH CCCCCCCCCCCCCCC	40.72	-
112	Acetylation	NTSKFAQKYGGAEKC CHHHHHHHHCCCHHC	42.29	23806337
125	Phosphorylation	KCSRCGDSVYAAEKI HCCCCCCHHHHHHHH	11.43	23737553
131	Acetylation	DSVYAAEKIIGAGKP CHHHHHHHHHCCCCC	34.59	-
137	Succinylation	EKIIGAGKPWHKNCF HHHHCCCCCCCCCCH	44.38	-
137	Acetylation	EKIIGAGKPWHKNCF HHHHCCCCCCCCCCH	44.38	23806337
137	Succinylation	EKIIGAGKPWHKNCF HHHHCCCCCCCCCCH	44.38	23806337
161	Acetylation	ESTTLTEKEGEIYCK CCCCCCEECCEEEEC	66.82	-
173	Acetylation	YCKGCYAKNFGPKGF EECCCEECCCCCCCC	26.74	23806337
182	Phosphorylation	FGPKGFGYGQGAGAL CCCCCCCCCCCCCCE	12.19	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSRP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSRP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSRP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CSRP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.