| UniProt ID | DD19A_MOUSE | |
|---|---|---|
| UniProt AC | Q61655 | |
| Protein Name | ATP-dependent RNA helicase DDX19A | |
| Gene Name | Ddx19a | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 478 | |
| Subcellular Localization |
Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane Peripheral membrane protein Cytoplasmic side. Nuclear pore complex cytoplasmic fibrils. |
|
| Protein Description | ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).. | |
| Protein Sequence | MATDSWALAVDEQEAAVKSMSSLQIKEEKVKADTNGVIKTSTTAEKTEEEEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDPSSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENALPMMLAEPPQNLIAQSQSGTGKTAAFVLAMLSRVEPADRYPQCLCLSPTYELALQTGKVIEQMGKFHPELKLAYAVRGNKLERGQKVSEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNIIKLKREEETLDTIKQYYVLCNNREEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MATDSWALA ------CCCCCCEEE | 21.80 | - | |
| 19 | Phosphorylation | EQEAAVKSMSSLQIK HHHHHHHHHHCCCCC | 19.80 | 29514104 | |
| 22 | Phosphorylation | AAVKSMSSLQIKEEK HHHHHHHCCCCCEEE | 18.69 | 29514104 | |
| 42 | Phosphorylation | NGVIKTSTTAEKTEE CCCEECCCCCCCCHH | 34.94 | - | |
| 59 | Phosphorylation | KEDRAAQSLLNKLIR HHHHHHHHHHHHHHH | 30.05 | 29899451 | |
| 63 | Acetylation | AAQSLLNKLIRSNLV HHHHHHHHHHHCCCC | 45.31 | 22826441 | |
| 63 | Ubiquitination | AAQSLLNKLIRSNLV HHHHHHHHHHHCCCC | 45.31 | 22790023 | |
| 84 | Phosphorylation | EVLQRDPSSPLYSVK EEECCCCCCCCCCCC | 49.21 | 28833060 | |
| 85 | Phosphorylation | VLQRDPSSPLYSVKS EECCCCCCCCCCCCC | 25.06 | 26824392 | |
| 88 | Phosphorylation | RDPSSPLYSVKSFEE CCCCCCCCCCCCHHH | 18.14 | 28833060 | |
| 89 | Phosphorylation | DPSSPLYSVKSFEEL CCCCCCCCCCCHHHH | 30.65 | 28833060 | |
| 92 | Phosphorylation | SPLYSVKSFEELRLK CCCCCCCCHHHHCCC | 35.42 | 26824392 | |
| 144 | Phosphorylation | SQSGTGKTAAFVLAM CCCCCCHHHHHHHHH | 25.27 | 25159016 | |
| 286 | Ubiquitination | SVWKFAQKVVPDPNI HHHHHHHHHCCCCCE | 41.59 | 22790023 | |
| 343 | Acetylation | MIFCHTRKTASWLAA HHHHCCHHHHHHHHH | 49.99 | 22826441 | |
| 392 | Glutathionylation | VLVTTNVCARGIDVE EEEEECCCCCCCCHH | 2.01 | 24333276 | |
| 392 | S-palmitoylation | VLVTTNVCARGIDVE EEEEECCCCCCCCHH | 2.01 | 28526873 | |
| 445 | Ubiquitination | AVNMVDSKHSMNILN EEEECCCHHHHHHHH | 34.92 | 22790023 | |
| 467 | Phosphorylation | KKIERLDTDDLDEIE HHHHCCCCCCHHHHH | 35.68 | 26643407 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DD19A_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DD19A_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DD19A_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of DD19A_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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