CWC22_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CWC22_MOUSE
• UniProt AC: Q8C5N3
• Protein Name: Pre-mRNA-splicing factor CWC22 homolog
• Gene Name: Cwc22
• Organism: Mus musculus (Mouse).
• Sequence Length: 908
• Subcellular Localization: Nucleus. Nucleus speckle. Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins..
• Protein Description: Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity)..
• Protein Sequence: MKSSVAHMKSSGHNRRETHSSYRRSSSPEDRYTEQERSPRDRGYSDYSRSDYERSRRGYSYDDSMESRSRDREKRRERERDADHRKRSRKSPSPDRSPARGGGQSSPQEEPTWKKKKDELDPLLTRTGGAYIPPAKLRMMQEQITDKSSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLKECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPVILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEILDEGDSDSNTDQGAGSSEDEEEEDEEEEGEDEEGGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFAESQTKELCNMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFESIFKEQYDTIHRLETNKLRNVAKMFAHLLYTDSLPWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPRNTRFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPEAEQKKPALTSSSSESSSASDSSDSESDSSESSSESSSDASDSSSSSSTQSSTSGITAHSAKGTRKKRQGKARGEEVDKLARGHQALERRREGGREDQRHQEGRTERARSERRRAQNSRDADWRDPLAKHIDDRSHENSHSRVGNGREQGSHREPEDRHGEPKKRRERRDSFSENEKQRSRNQDSDNVRRKDRSKSRERSRRHSGHKGDDARCQNSAERRWEKPGRRPEQSRESKRSQDRRREKSPTTQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Acetylation	KSSVAHMKSSGHNRR CCCCCCCCCCCCCCC	31.44	6565905
20	Phosphorylation	HNRRETHSSYRRSSS CCCCCCCCCCCCCCC	36.16	23684622
21	Phosphorylation	NRRETHSSYRRSSSP CCCCCCCCCCCCCCH	18.30	23684622
22	Phosphorylation	RRETHSSYRRSSSPE CCCCCCCCCCCCCHH	17.04	23684622
25	Phosphorylation	THSSYRRSSSPEDRY CCCCCCCCCCHHHHH	26.60	26643407
26	Phosphorylation	HSSYRRSSSPEDRYT CCCCCCCCCHHHHHC	48.37	25266776
27	Phosphorylation	SSYRRSSSPEDRYTE CCCCCCCCHHHHHCC	33.29	26643407
32	Phosphorylation	SSSPEDRYTEQERSP CCCHHHHHCCCCCCC	27.27	25159016
33	Phosphorylation	SSPEDRYTEQERSPR CCHHHHHCCCCCCCC	31.89	25159016
38	Phosphorylation	RYTEQERSPRDRGYS HHCCCCCCCCCCCCC	24.43	26824392
50	Phosphorylation	GYSDYSRSDYERSRR CCCCCCHHHHHHHHC	38.31	28285833
55	Phosphorylation	SRSDYERSRRGYSYD CHHHHHHHHCCCCCC	17.87	26643407
59	Phosphorylation	YERSRRGYSYDDSME HHHHHCCCCCCCHHH	11.40	23684622
60	Phosphorylation	ERSRRGYSYDDSMES HHHHCCCCCCCHHHH	25.55	25521595
61	Phosphorylation	RSRRGYSYDDSMESR HHHCCCCCCCHHHHH	18.45	21082442
64	Phosphorylation	RGYSYDDSMESRSRD CCCCCCCHHHHHHHH	22.88	28833060
67	Phosphorylation	SYDDSMESRSRDREK CCCCHHHHHHHHHHH	27.24	28833060
88	Phosphorylation	DADHRKRSRKSPSPD HHHHHHHHCCCCCCC	47.28	28066266
91	Phosphorylation	HRKRSRKSPSPDRSP HHHHHCCCCCCCCCC	29.51	25521595
93	Phosphorylation	KRSRKSPSPDRSPAR HHHCCCCCCCCCCCC	46.66	25521595
97	Phosphorylation	KSPSPDRSPARGGGQ CCCCCCCCCCCCCCC	30.23	25521595
105	Phosphorylation	PARGGGQSSPQEEPT CCCCCCCCCCCCCCC	47.46	25521595
106	Phosphorylation	ARGGGQSSPQEEPTW CCCCCCCCCCCCCCC	23.79	25521595
112	Phosphorylation	SSPQEEPTWKKKKDE CCCCCCCCCCCCHHH	53.87	28833060
125	Phosphorylation	DELDPLLTRTGGAYI HHCCCCHHHCCCCCC	33.59	28059163
328	Acetylation	LHESEIDKRVQYMIE HCHHHHHHHHHHHHH	61.19	7719727
409	Phosphorylation	EILDEGDSDSNTDQG HHHCCCCCCCCCCCC	54.52	25338131
411	Phosphorylation	LDEGDSDSNTDQGAG HCCCCCCCCCCCCCC	45.65	25338131
413	Phosphorylation	EGDSDSNTDQGAGSS CCCCCCCCCCCCCCC	33.38	25338131
419	Phosphorylation	NTDQGAGSSEDEEEE CCCCCCCCCCCCHHH	29.98	25338131
420	Phosphorylation	TDQGAGSSEDEEEED CCCCCCCCCCCHHHH	48.42	25338131
578	Phosphorylation	EETTTSSSRIFVKIF CCCCCCCHHHHHHHH	29.21	-
776	Phosphorylation	ERRRAQNSRDADWRD HHHHHHHHCCCCCCC	21.32	26824392
829	Phosphorylation	KRRERRDSFSENEKQ CHHHHHHCCCHHHHH	28.94	27087446
831	Phosphorylation	RERRDSFSENEKQRS HHHHHCCCHHHHHHH	43.39	27742792
862	Phosphorylation	RERSRRHSGHKGDDA HHHHHHHCCCCCCCH	40.56	25266776
874	Phosphorylation	DDARCQNSAERRWEK CCHHHCCHHHHHHCC	12.96	20469934
903	Phosphorylation	QDRRREKSPTTQK-- HHHHHHHCCCCCC--	23.79	25266776
905	Phosphorylation	RRREKSPTTQK---- HHHHHCCCCCC----	49.29	20531401
906	Phosphorylation	RREKSPTTQK----- HHHHCCCCCC-----	37.43	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CWC22_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CWC22_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CWC22_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CWC22_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-829, AND MASSSPECTROMETRY.
PubMed: 19367708