SYFA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYFA_MOUSE
• UniProt AC: Q8C0C7
• Protein Name: Phenylalanine--tRNA ligase alpha subunit
• Gene Name: Farsa
• Organism: Mus musculus (Mouse).
• Sequence Length: 508
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MADNPVLELLLRRLEVADGGLDSAELATQLGVEHQAVVGAVKSLQALGEVIEAELRSTKCWELTTEGEEIAREGSHEARVFRSIPLEGLVQSELMHLPSGKVGFSKAMSNKWIRVDKSAADGPRVFRVVDSIEDEVQKRLQLVQAGQAEKLAEKERNELRKRKLLTEVILKTYWVSKGKAFSTSVSKQEAELSPEMISSGSWRDRPFKPYNFSARGVLPDSGHLHPLLKVRSQFRQIFLEMGFTEMPTDNFIESSFWNFDALFQPQQHPARDQHDTFFLRDPAEALQLPMGYVQRVKRTHSQGGYGSQGYKYTWKLEEARKNLLRTHTTAASARALYQLAQKKPFTPAKYFSIDRVFRNETLDATHLAEFHQIEGVIADHGLTLGHLMGVLREFFTKLGITQLRFKPAYNPYTEPSMEVFSYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAWGLSLERPTMIKYGINNIRELVGHKVNLQMVYDSPVCRLDIEPRSSKTQEAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADNPVLEL ------CCCCHHHHH	25.86	-
43	Phosphorylation	AVVGAVKSLQALGEV HHHHHHHHHHHHHHH	21.08	25293948
59	Malonylation	EAELRSTKCWELTTE HHHHHCCCEEEEECC	38.30	26320211
60	Glutathionylation	AELRSTKCWELTTEG HHHHCCCEEEEECCH	3.28	24333276
64	Phosphorylation	STKCWELTTEGEEIA CCCEEEEECCHHHHH	15.99	21082442
65	Phosphorylation	TKCWELTTEGEEIAR CCEEEEECCHHHHHH	55.40	21082442
80	Ubiquitination	EGSHEARVFRSIPLE CCCCHHEEEECCCCH	6.36	27667366
106	Malonylation	SGKVGFSKAMSNKWI CCCCCCCHHHCCCEE	45.94	26320211
111	Malonylation	FSKAMSNKWIRVDKS CCHHHCCCEEEEEHH	36.37	26320211
117	Malonylation	NKWIRVDKSAADGPR CCEEEEEHHHCCCCC	38.85	26320211
138	Malonylation	SIEDEVQKRLQLVQA CHHHHHHHHHHHHHH	61.32	26320211
150	Malonylation	VQAGQAEKLAEKERN HHHHHHHHHHHHHHH	56.89	26320211
150	Ubiquitination	VQAGQAEKLAEKERN HHHHHHHHHHHHHHH	56.89	-
163	Malonylation	RNELRKRKLLTEVIL HHHHHHHHHHHHHHH	51.38	26320211
179	Malonylation	TYWVSKGKAFSTSVS HHHHHCCCCCCCCCC	50.42	26320211
184	Phosphorylation	KGKAFSTSVSKQEAE CCCCCCCCCCHHHHC	24.16	29514104
187	Ubiquitination	AFSTSVSKQEAELSP CCCCCCCHHHHCCCH	50.42	22790023
193	Phosphorylation	SKQEAELSPEMISSG CHHHHCCCHHHHHCC	15.43	28066266
199	Phosphorylation	LSPEMISSGSWRDRP CCHHHHHCCCCCCCC	26.39	23140645
201	Phosphorylation	PEMISSGSWRDRPFK HHHHHCCCCCCCCCC	22.38	23140645
208	Ubiquitination	SWRDRPFKPYNFSAR CCCCCCCCCCCCCCC	49.64	22790023
210	Phosphorylation	RDRPFKPYNFSARGV CCCCCCCCCCCCCEE	29.45	29514104
299	Phosphorylation	YVQRVKRTHSQGGYG HHHHCEECCCCCCCC	21.84	26643407
301	Phosphorylation	QRVKRTHSQGGYGSQ HHCEECCCCCCCCCC	29.88	26824392
305	Phosphorylation	RTHSQGGYGSQGYKY ECCCCCCCCCCCCEE	22.04	25777480
307	Phosphorylation	HSQGGYGSQGYKYTW CCCCCCCCCCCEEEE	16.37	25777480
310	Phosphorylation	GGYGSQGYKYTWKLE CCCCCCCCEEEEEHH	7.99	25777480
311	Acetylation	GYGSQGYKYTWKLEE CCCCCCCEEEEEHHH	42.92	-
315	Acetylation	QGYKYTWKLEEARKN CCCEEEEEHHHHHHH	37.92	23864654
315	Malonylation	QGYKYTWKLEEARKN CCCEEEEEHHHHHHH	37.92	26320211
337	Phosphorylation	AASARALYQLAQKKP HHHHHHHHHHHHCCC	10.65	29514104
346	Phosphorylation	LAQKKPFTPAKYFSI HHHCCCCCCCCCCEE	30.75	-
481	Acetylation	IRELVGHKVNLQMVY HHHHHCCCCEEEEEE	27.22	23864654

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYFA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYFA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYFA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SYFA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.