GPAT1_MOUSE - dbPTM
GPAT1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GPAT1_MOUSE
UniProt AC Q61586
Protein Name Glycerol-3-phosphate acyltransferase 1, mitochondrial
Gene Name Gpam
Organism Mus musculus (Mouse).
Sequence Length 827
Subcellular Localization Mitochondrion outer membrane
Multi-pass membrane protein .
Protein Description Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis..
Protein Sequence MEESSVTVGTIDVSYLPSSSEYSLGRCKHTSEDWVDCGFKPTFFRSATLKWKESLMSRKRPFVGRCCYSCTPQSWERFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYILFVQERDVHKGMFATSVTENVLSSSRVQEAIAEVAAELNPDGSAQQQSKAIQKVKRKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRRLDETPDGRKDILYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSSNTIPDILVIPVGISYDRIIEGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGYVRVDFAQPFSLKEYLEGQSQKPVSAPLSLEQALLPAILPSRPNDVADEHQDLSSNESRNPADEAFRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGIHLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLLGNCVTITHTSRKDEFFITPSTTVPSVFELNFYSNGVLHVFIMEAIIACSIYAVLNKRCSGGSAGGLGNLISQEQLVRKAASLCYLLSNEGTISLPCQTFYQVCHETVGKFIQYGILTVAEQDDQEDVSPGLAEQQWDKKLPELNWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITFLQRLLGPLLEAYSSAAIFVHNFSGPVPESEYLQKLHRYLITRTERNVAVYAESATYCLVKNAVKMFKDIGVFKETKQKRVSVLELSSTFLPQCNRQKLLEYILSFVVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
30PhosphorylationSLGRCKHTSEDWVDC
CCCCCCCCCCCCCCC		21.2123984901
31PhosphorylationLGRCKHTSEDWVDCG
CCCCCCCCCCCCCCC		33.0225521595
40UbiquitinationDWVDCGFKPTFFRSA
CCCCCCCCCCCCHHC		28.56-
48PhosphorylationPTFFRSATLKWKESL
CCCCHHCCHHHHHHH		30.0723140645
50UbiquitinationFFRSATLKWKESLMS
CCHHCCHHHHHHHHH		52.4427667366
110PhosphorylationGWLARRLSYILFVQE
HHHHHHHHEEEEEEC		14.3323140645
111PhosphorylationWLARRLSYILFVQER
HHHHHHHEEEEEECC		13.2623567750
182PhosphorylationQEMVATVSPGMIRLT
HHHHHHCCHHHHHHH		16.0428285833
288MalonylationDETPDGRKDILYRAL
CCCCCCCHHHHHHHH		55.4326073543
338PhosphorylationLLSVVVDTLSSNTIP
HHHHHHHHCCCCCCC		19.55-
371AcetylationYNGEQLGKPKKNESL
CCHHHCCCCCCCHHH		63.3623954790
374MalonylationEQLGKPKKNESLWSV
HHCCCCCCCHHHHHH		74.5826320211
380PhosphorylationKKNESLWSVARGVIR
CCCHHHHHHHHHHHH		15.93-
391UbiquitinationGVIRMLRKNYGYVRV
HHHHHHHHHCCEEEE		51.0327667366
448PhosphorylationADEHQDLSSNESRNP
CHHCCCCCCCCCCCH		39.1330352176
598S-palmitoylationYAVLNKRCSGGSAGG
HHHHCCCCCCCCCCH		4.7828526873
657PhosphorylationFIQYGILTVAEQDDQ
HHHCCEEEEECCCCC		18.7523140645
668PhosphorylationQDDQEDVSPGLAEQQ
CCCCCCCCCCHHHHH		26.1026643407
687PhosphorylationLPELNWRSDEEDEDS
CCCCCCCCCCCCCCC		40.7725521595
694PhosphorylationSDEEDEDSDFGEEQR
CCCCCCCCCCCHHHH		32.5625521595
704PhosphorylationGEEQRDCYLKVSQSK
CHHHHHEEEEECCCH		17.5323140645
779MalonylationSATYCLVKNAVKMFK
CHHHHHHHHHHHHHH		26.6626073543
779AcetylationSATYCLVKNAVKMFK
CHHHHHHHHHHHHHH		26.6623576753
783UbiquitinationCLVKNAVKMFKDIGV
HHHHHHHHHHHHHCC		35.8927667366
783MalonylationCLVKNAVKMFKDIGV
HHHHHHHHHHHHHCC		35.8926320211
783AcetylationCLVKNAVKMFKDIGV
HHHHHHHHHHHHHCC		35.8923576753
786MalonylationKNAVKMFKDIGVFKE
HHHHHHHHHHCCCHH		44.9632601280
786AcetylationKNAVKMFKDIGVFKE
HHHHHHHHHHCCCHH		44.9623954790
800PhosphorylationETKQKRVSVLELSST
HHCCCEEEEEHHHCC		25.6423140645
812S-palmitoylationSSTFLPQCNRQKLLE
HCCCCCCCCHHHHHH		4.2428526873
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GPAT1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GPAT1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GPAT1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GPAT1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GPAT1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Mitochondrial phosphoproteome revealed by an improved IMAC method andMS/MS/MS.";
Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.;
Mol. Cell. Proteomics 6:669-676(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694, AND MASSSPECTROMETRY.
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694, AND MASSSPECTROMETRY.

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