IF4A1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF4A1_MOUSE
• UniProt AC: P60843
• Protein Name: Eukaryotic initiation factor 4A-I
• Gene Name: Eif4a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 406
• Protein Description: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon..
• Protein Sequence: MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSASQDSRS ------CCCCCCCCC	36.31	-
4	Phosphorylation	----MSASQDSRSRD ----CCCCCCCCCCC	27.49	-
9	Phosphorylation	SASQDSRSRDNGPDG CCCCCCCCCCCCCCC	48.19	26239621
48	Phosphorylation	ESLLRGIYAYGFEKP HHHHHHHHHHCCCCC	9.15	22499769
50	Phosphorylation	LLRGIYAYGFEKPSA HHHHHHHHCCCCCCH	12.84	22499769
54	Acetylation	IYAYGFEKPSAIQQR HHHHCCCCCCHHHHH	41.85	22642847
54	Ubiquitination	IYAYGFEKPSAIQQR HHHHCCCCCCHHHHH	41.85	22790023
66	S-nitrosylation	QQRAILPCIKGYDVI HHHCHHHHHCCCEEE	4.50	20925432
66	S-nitrosocysteine	QQRAILPCIKGYDVI HHHCHHHHHCCCEEE	4.50	-
66	Glutathionylation	QQRAILPCIKGYDVI HHHCHHHHHCCCEEE	4.50	24333276
68	Ubiquitination	RAILPCIKGYDVIAQ HCHHHHHCCCEEEEE	59.12	22790023
68	Acetylation	RAILPCIKGYDVIAQ HCHHHHHCCCEEEEE	59.12	22826441
70	Phosphorylation	ILPCIKGYDVIAQAQ HHHHHCCCEEEEEEC	11.31	29514104
80	Phosphorylation	IAQAQSGTGKTATFA EEEECCCCCHHHHHH	40.53	29514104
101	Phosphorylation	IELDLKATQALVLAP HCCCCHHHHHHHHHC	16.88	-
118	Acetylation	ELAQQIQKVVMALGD HHHHHHHHHHHHHHH	38.12	22826441
118	Ubiquitination	ELAQQIQKVVMALGD HHHHHHHHHHHHHHH	38.12	-
126	Phosphorylation	VVMALGDYMGASCHA HHHHHHHHCCCCCCC	8.82	22817900
131	S-nitrosocysteine	GDYMGASCHACIGGT HHHCCCCCCCCCCCC	2.03	-
131	S-nitrosylation	GDYMGASCHACIGGT HHHCCCCCCCCCCCC	2.03	20925432
134	S-nitrosocysteine	MGASCHACIGGTNVR CCCCCCCCCCCCHHH	1.01	-
134	S-nitrosylation	MGASCHACIGGTNVR CCCCCCCCCCCCHHH	1.01	20925432
146	Ubiquitination	NVRAEVQKLQMEAPH HHHHHHHHHHHCCCE	45.95	-
146	Malonylation	NVRAEVQKLQMEAPH HHHHHHHHHHHCCCE	45.95	26320211
146	Acetylation	NVRAEVQKLQMEAPH HHHHHHHHHHHCCCE	45.95	23806337
158	Phosphorylation	APHIIVGTPGRVFDM CCEEEEECCCHHHHH	16.21	28066266
174	Malonylation	NRRYLSPKYIKMFVL CCCCCCHHHEEEEEC	57.12	26320211
174	Acetylation	NRRYLSPKYIKMFVL CCCCCCHHHEEEEEC	57.12	23954790
174	Ubiquitination	NRRYLSPKYIKMFVL CCCCCCHHHEEEEEC	57.12	-
177	Acetylation	YLSPKYIKMFVLDEA CCCHHHEEEEECHHH	24.16	22826441
193	Ubiquitination	EMLSRGFKDQIYDIF HHHHCCCHHHHHHHH	52.10	-
193	Acetylation	EMLSRGFKDQIYDIF HHHHCCCHHHHHHHH	52.10	23806337
193	Succinylation	EMLSRGFKDQIYDIF HHHHCCCHHHHHHHH	52.10	23954790
197	Phosphorylation	RGFKDQIYDIFQKLN CCCHHHHHHHHHHCC	9.43	22817900
202	Ubiquitination	QIYDIFQKLNSNTQV HHHHHHHHCCCCCEE	38.60	-
205	Phosphorylation	DIFQKLNSNTQVVLL HHHHHCCCCCEEEEE	52.25	26643407
207	Phosphorylation	FQKLNSNTQVVLLSA HHHCCCCCEEEEEEC	23.67	26643407
225	Ubiquitination	SDVLEVTKKFMRDPI HHHHHHHHHHHCCCE	49.54	22790023
225	Acetylation	SDVLEVTKKFMRDPI HHHHHHHHHHHCCCE	49.54	23236377
226	Ubiquitination	DVLEVTKKFMRDPIR HHHHHHHHHHCCCEE	34.72	-
238	Ubiquitination	PIRILVKKEELTLEG CEEEEEECCEECHHH	49.28	-
238	Acetylation	PIRILVKKEELTLEG CEEEEEECCEECHHH	49.28	23806337
238	Malonylation	PIRILVKKEELTLEG CEEEEEECCEECHHH	49.28	26320211
250	Phosphorylation	LEGIRQFYINVEREE HHHHHHEEEEECCHH	5.35	25367039
284	Ubiquitination	IFINTRRKVDWLTEK HHHCCCCCCHHHHHH	41.05	-
291	Ubiquitination	KVDWLTEKMHARDFT CCHHHHHHHHHCCCC	30.65	22790023
300	Phosphorylation	HARDFTVSAMHGDMD HHCCCCCEECCCCCC	19.47	25890499
309	Malonylation	MHGDMDQKERDVIMR CCCCCCHHHHHHHHH	50.91	26320211
309	Acetylation	MHGDMDQKERDVIMR CCCCCCHHHHHHHHH	50.91	23236377
309	Ubiquitination	MHGDMDQKERDVIMR CCCCCCHHHHHHHHH	50.91	-
320	Phosphorylation	VIMREFRSGSSRVLI HHHHHHHCCCCCEEE	48.63	22871156
322	Phosphorylation	MREFRSGSSRVLITT HHHHHCCCCCEEEEH	19.06	22871156
329	Phosphorylation	SSRVLITTDLLARGI CCCEEEEHHHHHCCC	20.04	22006019
369	Ubiquitination	RGGRFGRKGVAINMV CCCCCCCCCEEEEEC	59.10	22790023
377	Phosphorylation	GVAINMVTEEDKRTL CEEEEECCHHHHHHH	23.92	21454597
381	Ubiquitination	NMVTEEDKRTLRDIE EECCHHHHHHHHHHH	51.03	22790023
391	Phosphorylation	LRDIETFYNTSIEEM HHHHHHHHCCCHHHC	25.58	26643407
393	Phosphorylation	DIETFYNTSIEEMPL HHHHHHCCCHHHCCC	21.50	26643407
394	Phosphorylation	IETFYNTSIEEMPLN HHHHHCCCHHHCCCC	25.10	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF4A1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF4A1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF4A1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IF4A1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.