EXOC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXOC2_MOUSE
• UniProt AC: Q9D4H1
• Protein Name: Exocyst complex component 2
• Gene Name: Exoc2
• Organism: Mus musculus (Mouse).
• Sequence Length: 924
• Subcellular Localization: Midbody, Midbody ring . Recruitment to the midbody does not require RALA, nor RALB. Colocalizes with CNTRL/centriolin at the midbody ring.
• Protein Description: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane..
• Protein Sequence: MSRSRQPPLVTGISPNEGIPWTKVTIRGENLGTGPTDLIGLTICGHNCLLTAEWMSASKIVCRVGQAKNDKGDIIVTTKSGGKGTSTVSFKLLKPEKIGILDQSAVWVDEMNYYDMRTDRNKGIPPLSLRPANPLGIEIEKCKLPQKNLEVLFHGMSADFTSENFSAAWYLIENHSTTSFEQLKMAVTNLKRQANKKSEGSLAYVKGGLSTFFEAQDALSAIHQKLEADGTEKVEGSMTQKLENVLNRASNTADTLFQEVLGRKDKADSTRNALNVLQRFKFLFNLPLNIKRNIQKGDYDVVINDYEKAKSLFGKTEVQVFKKYYAEVEAGIEDLRELLLKKLLETPSTLHDQKRYIRYLSDLHAPGDPAWQCIGAQHKWTLKLMQDCKEGHMKSLKGHPGPHSPMLDLDNDVRPSVLGHLSQTASLKRGSSFQSGRDDTWRYKTPHRVAFVEKLTKLVLSQLPNFWKLWISYVNGSLFSETAEKSGQSERSKNVRQRQNDFKKMIQEVMHSLVKLIRGALLPLSLREGDGRQYGGWEVQAELSGQWLAHVIQTIRLTYESLTALEIPNDMLQIIQDLILDLRIRCIMVTLQHTAEEIKRLAEKEDWVVDNEGLTSLPCQFEQSIVHSLQSLKGVVDCKPGEASVFQQPKTQEEVCQLCINIMQVFIYCLEQLSTKPDADIDTTHLSVDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCYLERHTFLNIAEHFEKHNFQGIEKITQVSMASLKELDQRLFENYIELKADPIVGSLEPGIYAGYFDWKDCLPPAGVRNYLKEALVNIIAVHAEVFTISKELVPRVLARVVEAVSEELSRLMQCVSSFSRNGALQARLEICALRDTVAIYLTSESRSSFKQALEALPQLASGADKKSLEELLNKFKSSMHLQLTCFQAASPAVMKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
191	Ubiquitination	KMAVTNLKRQANKKS HHHHHHHHHHHCCCC	44.53	27667366
204	Phosphorylation	KSEGSLAYVKGGLST CCCCCEEEECCCHHH	14.16	29514104
354	Acetylation	PSTLHDQKRYIRYLS CCCHHHHHHHHHHHH	53.91	23954790
404	Phosphorylation	KGHPGPHSPMLDLDN CCCCCCCCCCCCCCC	18.35	26824392
416	Phosphorylation	LDNDVRPSVLGHLSQ CCCCCCHHHHHHHHC	21.29	25367039
422	Phosphorylation	PSVLGHLSQTASLKR HHHHHHHHCCCCCCC	21.58	26643407
424	Phosphorylation	VLGHLSQTASLKRGS HHHHHHCCCCCCCCC	18.16	26643407
426	Phosphorylation	GHLSQTASLKRGSSF HHHHCCCCCCCCCCC	37.50	29514104
431	Phosphorylation	TASLKRGSSFQSGRD CCCCCCCCCCCCCCC	31.82	23684622
432	Phosphorylation	ASLKRGSSFQSGRDD CCCCCCCCCCCCCCC	30.08	26824392
435	Phosphorylation	KRGSSFQSGRDDTWR CCCCCCCCCCCCCCC	33.51	23684622
440	Phosphorylation	FQSGRDDTWRYKTPH CCCCCCCCCCCCCHH	19.01	23684622
454	Acetylation	HRVAFVEKLTKLVLS HHHHHHHHHHHHHHH	57.04	23236377
798	Phosphorylation	PPAGVRNYLKEALVN CCHHHHHHHHHHHHH	14.48	-
817	Phosphorylation	HAEVFTISKELVPRV CCCHHHCCHHHHHHH	19.61	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXOC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXOC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXOC2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EXOC2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435, AND MASSSPECTROMETRY.
PubMed: 17242355