CAN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAN1_MOUSE
• UniProt AC: O35350
• Protein Name: Calpain-1 catalytic subunit {ECO:0000305}
• Gene Name: Capn1 {ECO:0000312|MGI:MGI:88263}
• Organism: Mus musculus (Mouse).
• Sequence Length: 713
• Subcellular Localization: Cytoplasm . Cell membrane . Translocates to the plasma membrane upon Ca(2+) binding.
• Protein Description: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction..
• Protein Sequence: MTEELITPVYCTGVSAQVQKKRDKELGLGRHENAIKYLGQDYETLRARCLQSGVLFQDEAFPPVSHSLGFKELGPHSSKTYGIKWKRPTELMSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQDGYAGIFHFQLWQFGEWVDVVIDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTGAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDSSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNLTPDALKSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEEVDDADDYDNRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQVPRELAGQPVHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQELDDQIQANLPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKHKDLRTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMAIEAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKLLDTDLDGVVTFDLFKWLQLTMFA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MTEELITPVYCTGV -CCCCCCCCEECCCC	21.23	26643407
10	Phosphorylation	EELITPVYCTGVSAQ CCCCCCEECCCCCHH	5.86	26643407
12	Phosphorylation	LITPVYCTGVSAQVQ CCCCEECCCCCHHHH	23.96	26643407
15	Phosphorylation	PVYCTGVSAQVQKKR CEECCCCCHHHHHHH	17.83	26643407
77	Phosphorylation	FKELGPHSSKTYGIK CHHCCCCCCCCCCCC	36.34	30482847
93	Phosphorylation	KRPTELMSNPQFIVD CCCCHHHCCCEEEEC	58.96	28464351
180	Phosphorylation	GKLVFVHSAQGNEFW CEEEEEEECCCHHHH	19.58	29514104
232	Phosphorylation	YDLQKAPSDLYQIIL EECCCCCCHHHHHHH	45.14	29899451
235	Phosphorylation	QKAPSDLYQIILKAL CCCCCHHHHHHHHHH	11.58	29899451
266	Ubiquitination	DLEAITFKNLVRGHA CCEEEEECCCCCCCC	40.50	22790023
316	Acetylation	DSSYEWNKVDPYERE CCCCCCCCCCHHHHH	49.43	23954790
347	Acetylation	DFIREFTKLEICNLT HHHHHHHCCCHHCCC	49.82	22826441
347	Ubiquitination	DFIREFTKLEICNLT HHHHHHHCCCHHCCC	49.82	22790023
354	Phosphorylation	KLEICNLTPDALKSR CCCHHCCCHHHHHHC	12.72	-
359	Ubiquitination	NLTPDALKSRTLRNW CCCHHHHHHCCCCCC	39.34	22790023
379	Phosphorylation	EGTWRRGSTAGGCRN EECCCCCCCCCCCCC	17.17	-
387	Phosphorylation	TAGGCRNYPATFWVN CCCCCCCCCEEEEEC	3.79	-
390	Phosphorylation	GCRNYPATFWVNPQF CCCCCCEEEEECCCE	17.33	-
398	Ubiquitination	FWVNPQFKIRLEEVD EEECCCEEEEEEECC	22.97	22790023
469	Phosphorylation	DFFLANASRAQSEHF CEEECCCHHHHHHHC	28.14	-
538	Phosphorylation	LPDEKVLSEEEIDDN CCCCCCCCHHHCCHH	46.05	26525534
621	Phosphorylation	NRIRNYLTIFRKFDL HHHHHHHHHHHHCCC	14.01	-
631	Phosphorylation	RKFDLDKSGSMSAYE HHCCCCCCCCCCHHH	35.45	-
633	Phosphorylation	FDLDKSGSMSAYEMR CCCCCCCCCCHHHHH	19.36	28059163
635	Phosphorylation	LDKSGSMSAYEMRMA CCCCCCCCHHHHHHH	29.42	-
637	Phosphorylation	KSGSMSAYEMRMAIE CCCCCCHHHHHHHHH	11.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAN1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAN1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN5_MOUSE	Ptpn5	physical	19625523

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.