SYF1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYF1_MOUSE
• UniProt AC: Q9DCD2
• Protein Name: Pre-mRNA-splicing factor SYF1
• Gene Name: Xab2
• Organism: Mus musculus (Mouse).
• Sequence Length: 855
• Subcellular Localization: Nucleus . Detected in the splicing complex carrying pre-mRNA.
• Protein Description: Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing..
• Protein Sequence: MVVMARVPRSERPDLVFEEEDLPYEEEIMRNQFSVKCWLRYIEFKQGAPKPRLNQLYERALKLLPCSYKLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRGYRRFLKLSPESAEEYIEYLKSSDRLDEAAQRLATVVNDERFVSKAGKSNYQLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWCSLADYYIRSGHFEKARDVYEEAIRTVMTVRDFTQVFDSYAQFEESMIAAKMETASELGREEEDDVDLELRLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVALHQGRPREIINTYTEAVQTVDPFKATGKPHTLWVAFAKFYEDNGQLDDARVILEKATKVNFKQVDDLASVWCQCGELELRHENYDEALKLLRKATALPARRAEYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYDRILDLRIATPQIVINYAMFLEEHKYFEESFKAYERGISLFKWPNVSDIWSTYLTKFISRYGGRKLERARDLFEQALDGCPPKYAKTLYLLYAQLEEEWGLARHAMAVYDRATRAVEPAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLSDEHAREMCLRFADMECKLGEIDRARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGNEDTIREMLRIRRSVQATYNTQVNFMASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLAAEAERDQPPRAQSKIFFVRSDASREELAELAQQANPEEIQLGEDEDEDEMDLEPNEVRLEQQSVPAAVFGSLKED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
211	Phosphorylation	VNDERFVSKAGKSNY HCCHHHHHCCCCCHH	17.68	-
420	Acetylation	DARVILEKATKVNFK CHHHHHHHCCCCCCC	58.89	-
454	Ubiquitination	ENYDEALKLLRKATA CCHHHHHHHHHHHHC	53.15	-
460	Phosphorylation	LKLLRKATALPARRA HHHHHHHHCCCCHHH	31.59	22817900
793	Phosphorylation	DQPPRAQSKIFFVRS CCCCCCCCEEEEECC	27.08	27600695
794	Acetylation	QPPRAQSKIFFVRSD CCCCCCCEEEEECCC	31.30	23806337
803	Phosphorylation	FFVRSDASREELAEL EEECCCCCHHHHHHH	45.26	22802335
851	Phosphorylation	VPAAVFGSLKED--- CCHHHHCCCCCC---	25.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYF1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYF1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYF1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SYF1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.