YKT6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YKT6_MOUSE
• UniProt AC: Q9CQW1
• Protein Name: Synaptobrevin homolog YKT6
• Gene Name: Ykt6
• Organism: Mus musculus (Mouse).
• Sequence Length: 198
• Subcellular Localization: Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Probably cycles through vesicles between Golgi and endosomes..
• Protein Description: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity..
• Protein Sequence: MKLYSLSVLYKGDPKAVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSGKGSRASVKEQEYLCHVYVRSDSLAGVVIADSEYPSRVAFTLLEKVLDEFSKQVDRIDWPVGSPATIQYTGLDDHLSKYQNPREADPMSKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Acetylation	YSLSVLYKGDPKAVL EEEEEEECCCHHHHE	53.31	22826441
15	Acetylation	VLYKGDPKAVLLKAA EEECCCHHHHEEEEE	56.73	22826441
60	Acetylation	KGSRASVKEQEYLCH CCCCCCHHHCEEEEE	51.70	22826441
66	S-nitrosocysteine	VKEQEYLCHVYVRSD HHHCEEEEEEEECCC	1.68	-
66	S-nitrosylation	VKEQEYLCHVYVRSD HHHCEEEEEEEECCC	1.68	21278135
72	Phosphorylation	LCHVYVRSDSLAGVV EEEEEECCCCCCCEE	22.85	30635358
74	Phosphorylation	HVYVRSDSLAGVVIA EEEECCCCCCCEEEE	22.74	30635358
96	Acetylation	VAFTLLEKVLDEFSK HHHHHHHHHHHHHHH	48.33	22826441
103	Ubiquitination	KVLDEFSKQVDRIDW HHHHHHHHCCCCCCC	60.71	22790023
103	Acetylation	KVLDEFSKQVDRIDW HHHHHHHHCCCCCCC	60.71	22826441
130	Phosphorylation	LDDHLSKYQNPREAD CHHHHHHCCCHHHCC	15.33	29514104
150	Acetylation	QAELDETKIILHNTM HHHHHCCEEHHHHHH	26.21	22826441
159	Phosphorylation	ILHNTMESLLERGEK HHHHHHHHHHHHCCC	27.68	29514104
166	Ubiquitination	SLLERGEKLDDLVSK HHHHHCCCHHHHHHH	61.10	22790023
172	Phosphorylation	EKLDDLVSKSEVLGT CCHHHHHHHHHHHCH	37.45	28066266
174	Phosphorylation	LDDLVSKSEVLGTQS HHHHHHHHHHHCHHH	25.98	22942356
179	Phosphorylation	SKSEVLGTQSKAFYK HHHHHHCHHHHHHHH	26.05	28066266
181	Phosphorylation	SEVLGTQSKAFYKTA HHHHCHHHHHHHHHH	26.28	28066266
182	Ubiquitination	EVLGTQSKAFYKTAR HHHCHHHHHHHHHHH	32.47	22790023
182	Acetylation	EVLGTQSKAFYKTAR HHHCHHHHHHHHHHH	32.47	22826441
186	Acetylation	TQSKAFYKTARKQNS HHHHHHHHHHHHHCC	29.29	22826441
186	Malonylation	TQSKAFYKTARKQNS HHHHHHHHHHHHHCC	29.29	26320211
194	S-palmitoylation	TARKQNSCCAIM--- HHHHHCCCEECC---	2.08	-
195	Methylation	ARKQNSCCAIM---- HHHHCCCEECC----	2.63	-
195	Farnesylation	ARKQNSCCAIM---- HHHHCCCEECC----	2.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YKT6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YKT6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YKT6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STX5_MOUSE	Stx5a	physical	11323436
BET1_MOUSE	Bet1	physical	11323436
GOSR1_MOUSE	Gosr1	physical	11323436

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.