GOSR1_MOUSE - dbPTM
GOSR1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GOSR1_MOUSE
UniProt AC O88630
Protein Name Golgi SNAP receptor complex member 1
Gene Name Gosr1
Organism Mus musculus (Mouse).
Sequence Length 250
Subcellular Localization Golgi apparatus membrane
Single-pass type IV membrane protein . Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network. Enriched on vesicular components at the terminal rims of the Golgi..
Protein Description Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi (By similarity)..
Protein Sequence MAAGTSNYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSGSRDGGRDRYSSDTTPLLNGSSQDRMFETMAIEIEQLLARLTGVNDKMAEYTHSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANFTAIRERENLMGSVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSLILGGVIGICTILLLLYAFH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAAGTSNYW
------CCCCCCHHH
18.01-
6Phosphorylation--MAAGTSNYWEDLR
--CCCCCCHHHHHHH
27.3125338131
29PhosphorylationELDLKLVSFSKLCTS
HHHHHHHHHHHHHHH
39.0522324799
31PhosphorylationDLKLVSFSKLCTSYS
HHHHHHHHHHHHHCC
23.3422324799
34S-palmitoylationLVSFSKLCTSYSHSG
HHHHHHHHHHCCCCC
2.4626165157
35PhosphorylationVSFSKLCTSYSHSGS
HHHHHHHHHCCCCCC
40.9329472430
36PhosphorylationSFSKLCTSYSHSGSR
HHHHHHHHCCCCCCC
24.5229472430
38PhosphorylationSKLCTSYSHSGSRDG
HHHHHHCCCCCCCCC
15.7929472430
40PhosphorylationLCTSYSHSGSRDGGR
HHHHCCCCCCCCCCC
32.3029472430
42PhosphorylationTSYSHSGSRDGGRDR
HHCCCCCCCCCCCCC
30.1629472430
50PhosphorylationRDGGRDRYSSDTTPL
CCCCCCCCCCCCCCC
19.4730635358
51PhosphorylationDGGRDRYSSDTTPLL
CCCCCCCCCCCCCCC
23.7230635358
52PhosphorylationGGRDRYSSDTTPLLN
CCCCCCCCCCCCCCC
30.0030635358
54PhosphorylationRDRYSSDTTPLLNGS
CCCCCCCCCCCCCCC
32.0630635358
55PhosphorylationDRYSSDTTPLLNGSS
CCCCCCCCCCCCCCC
19.5530635358
141PhosphorylationERENLMGSVRKDIES
HHHHHHHHHHHHHHH
12.5629176673
148PhosphorylationSVRKDIESYKSGSGV
HHHHHHHHHHCCCCC
37.89-
149PhosphorylationVRKDIESYKSGSGVN
HHHHHHHHHCCCCCC
9.07-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GOSR1_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GOSR1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GOSR1_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GOSR1_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GOSR1_MOUSE

loading...

Related Literatures of Post-Translational Modification

TOP