UniProt ID | GOSR1_MOUSE | |
---|---|---|
UniProt AC | O88630 | |
Protein Name | Golgi SNAP receptor complex member 1 | |
Gene Name | Gosr1 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 250 | |
Subcellular Localization |
Golgi apparatus membrane Single-pass type IV membrane protein . Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network. Enriched on vesicular components at the terminal rims of the Golgi.. |
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Protein Description | Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi (By similarity).. | |
Protein Sequence | MAAGTSNYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSGSRDGGRDRYSSDTTPLLNGSSQDRMFETMAIEIEQLLARLTGVNDKMAEYTHSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANFTAIRERENLMGSVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSLILGGVIGICTILLLLYAFH | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Acetylation | ------MAAGTSNYW ------CCCCCCHHH | 18.01 | - | |
6 | Phosphorylation | --MAAGTSNYWEDLR --CCCCCCHHHHHHH | 27.31 | 25338131 | |
29 | Phosphorylation | ELDLKLVSFSKLCTS HHHHHHHHHHHHHHH | 39.05 | 22324799 | |
31 | Phosphorylation | DLKLVSFSKLCTSYS HHHHHHHHHHHHHCC | 23.34 | 22324799 | |
34 | S-palmitoylation | LVSFSKLCTSYSHSG HHHHHHHHHHCCCCC | 2.46 | 26165157 | |
35 | Phosphorylation | VSFSKLCTSYSHSGS HHHHHHHHHCCCCCC | 40.93 | 29472430 | |
36 | Phosphorylation | SFSKLCTSYSHSGSR HHHHHHHHCCCCCCC | 24.52 | 29472430 | |
38 | Phosphorylation | SKLCTSYSHSGSRDG HHHHHHCCCCCCCCC | 15.79 | 29472430 | |
40 | Phosphorylation | LCTSYSHSGSRDGGR HHHHCCCCCCCCCCC | 32.30 | 29472430 | |
42 | Phosphorylation | TSYSHSGSRDGGRDR HHCCCCCCCCCCCCC | 30.16 | 29472430 | |
50 | Phosphorylation | RDGGRDRYSSDTTPL CCCCCCCCCCCCCCC | 19.47 | 30635358 | |
51 | Phosphorylation | DGGRDRYSSDTTPLL CCCCCCCCCCCCCCC | 23.72 | 30635358 | |
52 | Phosphorylation | GGRDRYSSDTTPLLN CCCCCCCCCCCCCCC | 30.00 | 30635358 | |
54 | Phosphorylation | RDRYSSDTTPLLNGS CCCCCCCCCCCCCCC | 32.06 | 30635358 | |
55 | Phosphorylation | DRYSSDTTPLLNGSS CCCCCCCCCCCCCCC | 19.55 | 30635358 | |
141 | Phosphorylation | ERENLMGSVRKDIES HHHHHHHHHHHHHHH | 12.56 | 29176673 | |
148 | Phosphorylation | SVRKDIESYKSGSGV HHHHHHHHHHCCCCC | 37.89 | - | |
149 | Phosphorylation | VRKDIESYKSGSGVN HHHHHHHHHCCCCCC | 9.07 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GOSR1_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GOSR1_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GOSR1_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of GOSR1_MOUSE !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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