DDX17_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX17_MOUSE
• UniProt AC: Q501J6
• Protein Name: Probable ATP-dependent RNA helicase DDX17
• Gene Name: Ddx17
• Organism: Mus musculus (Mouse).
• Sequence Length: 650
• Subcellular Localization: Nucleus . Nucleus, nucleolus . Cytoplasm, cytosol . In the course of bunyavirus infection, relocalizes from the nucleus to the cytosol where it binds viral RNA to antagonize replication.
• Protein Description: As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features. This function requires the RNA helicase activity. Affects NFAT5 and histone macro-H2A.1/H2AFY alternative splicing in a CDK9-dependent manner. Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1 and transcriptional regulators. By acting splicing of regulatory factors, participates in ESR1 and AR stabilization. Promotes the inclusion of specific AC-rich alternative exons in CD44 transcripts. In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons. In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR132/miR-132, and stabilizes the primary transcript. Also participates in the MIR132 processing, resulting in significantly higher levels of mature MIR132 than MIR212 despite the fact that both are cotranscribed and co-regulated. [PubMed: 26947125 Binding of pri-microRNAs may occur on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (By similarity Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs. Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S rRNA. Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists. Enhances NFAT5 transcriptional activity. Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues. May also coactivate MDM2 transcription through a TP53-independent pathway. Coactivates MMP7 transcription. Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription. Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes]
• Protein Sequence: MRGGGFGDRDRDRDRGGFGARGGSGLPPKKFGNPGERLRKKKWDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIKVLEEANQAINPKLMQLVDHRGGGGGGGGRSRYRTTSSANNPNLMYQDECDRRLRGVKDGGRRDSTSYRDRSETDRASYANGSGYGSPNSAFGAQAGQYTYAQGTYGAAAYGTSGYTAQEYAAGTYGASSTASAGRSSQSSSQQFSGIGRSGQQPQPLMSQQFAQPPGATNMIGYMGQTAYQYPPPPPPPPPSRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MRGGGFGDR ------CCCCCCCCC	53.08	-
21	Methylation	DRGGFGARGGSGLPP CCCCCCCCCCCCCCC	50.84	-
29	Acetylation	GGSGLPPKKFGNPGE CCCCCCCHHHCCHHH	59.81	-
30	Acetylation	GSGLPPKKFGNPGER CCCCCCHHHCCHHHH	65.36	-
42	Acetylation	GERLRKKKWDLSELP HHHHHHCCCCHHHCC	49.31	-
50	Sumoylation	WDLSELPKFEKNFYV CCHHHCCCCCCCEEC	77.95	-
50	Acetylation	WDLSELPKFEKNFYV CCHHHCCCCCCCEEC	77.95	15609695
53	Acetylation	SELPKFEKNFYVEHP HHCCCCCCCEECCCH	56.33	15609701
168	Glutathionylation	ERGDGPICLVLAPTR CCCCCCEEEEEECHH	2.12	24333276
168	S-nitrosylation	ERGDGPICLVLAPTR CCCCCCEEEEEECHH	2.12	20925432
168	S-nitrosocysteine	ERGDGPICLVLAPTR CCCCCCEEEEEECHH	2.12	-
196	Phosphorylation	GKCSRLKSTCIYGGA CCCHHCCCCEEECCC	32.86	22499769
197	Phosphorylation	KCSRLKSTCIYGGAP CCHHCCCCEEECCCC	11.01	22499769
198	Glutathionylation	CSRLKSTCIYGGAPK CHHCCCCEEECCCCC	2.66	24333276
200	Phosphorylation	RLKSTCIYGGAPKGP HCCCCEEECCCCCCC	16.20	22499769
205	Ubiquitination	CIYGGAPKGPQIRDL EEECCCCCCCCCCCH	80.72	-
219	S-nitrosylation	LERGVEICIATPGRL HHCCEEEEEECCCHH	0.80	20925432
219	S-nitrosocysteine	LERGVEICIATPGRL HHCCEEEEEECCCHH	0.80	-
222	Phosphorylation	GVEICIATPGRLIDF CEEEEEECCCHHHHH	13.33	26745281
282	Ubiquitination	MWSATWPKEVRQLAE EEECCCCHHHHHHHH	61.47	-
374	Phosphorylation	MCIHGDKSQPERDWV EEECCCCCCCHHHHH	56.56	20139300
400	Phosphorylation	LIATDVASRGLDVED EEEECHHHCCCCHHH	27.08	29514104
436	Ubiquitination	RTARSTNKGTAYTFF CCCCCCCCCCEEEEE	58.70	-
444	Phosphorylation	GTAYTFFTPGNLKQA CCEEEEECCCCHHHH	26.54	-
449	Ubiquitination	FFTPGNLKQARELIK EECCCCHHHHHHHHH	46.00	-
488	Phosphorylation	GGGGRSRYRTTSSAN CCCCCCCCCCCCCCC	17.35	26060331
490	Phosphorylation	GGRSRYRTTSSANNP CCCCCCCCCCCCCCC	23.30	26643407
491	Phosphorylation	GRSRYRTTSSANNPN CCCCCCCCCCCCCCC	16.22	26643407
492	Phosphorylation	RSRYRTTSSANNPNL CCCCCCCCCCCCCCC	27.17	24453211
493	Phosphorylation	SRYRTTSSANNPNLM CCCCCCCCCCCCCCC	32.68	26643407
501	Phosphorylation	ANNPNLMYQDECDRR CCCCCCCCCCHHHHH	18.91	25777480
520	Phosphorylation	KDGGRRDSTSYRDRS CCCCCCCCCCCCCCC	19.90	26824392
521	Phosphorylation	DGGRRDSTSYRDRSE CCCCCCCCCCCCCCC	33.78	25521595
522	Phosphorylation	GGRRDSTSYRDRSET CCCCCCCCCCCCCCC	23.32	25266776
523	Phosphorylation	GRRDSTSYRDRSETD CCCCCCCCCCCCCCC	19.34	29899451
527	Phosphorylation	STSYRDRSETDRASY CCCCCCCCCCCCCHH	49.49	29899451
592	Phosphorylation	STASAGRSSQSSSQQ CCCCCCCCCCCCCCC	31.63	29472430
593	Phosphorylation	TASAGRSSQSSSQQF CCCCCCCCCCCCCCC	32.49	29472430
595	Phosphorylation	SAGRSSQSSSQQFSG CCCCCCCCCCCCCCC	33.63	29514104
596	Phosphorylation	AGRSSQSSSQQFSGI CCCCCCCCCCCCCCC	25.24	29514104
597	Phosphorylation	GRSSQSSSQQFSGIG CCCCCCCCCCCCCCC	32.99	29514104
605	Methylation	QQFSGIGRSGQQPQP CCCCCCCCCCCCCCC	35.38	24129315

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDX17_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX17_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX17_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DDX17_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.