RBGPR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBGPR_MOUSE
• UniProt AC: Q8BMG7
• Protein Name: Rab3 GTPase-activating protein non-catalytic subunit
• Gene Name: Rab3gap2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1366
• Subcellular Localization: Cytoplasm. In neurons, it is enriched in the synaptic soluble fraction..
• Protein Description: Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity)..
• Protein Sequence: MACSIVQFCSFQDLQSARDFLFPHLREETPGALKRDPSKTSSWEDDSWGAWEETEPREPEEEGNTSKTQKNSWLQECVLSLSPTSDLMVIAREQKAAFLVRKWKHGDKGKEEMQFAVGWSGSVSAEEGEYVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTEGVLLLAQLLNEDKVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASVGIMTLSPFDQMKTASNIGGFNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFSAASGWLGWKSKHEEDTVQKQKPKMEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQVGWIQIVEDLHERVPEKGGFSPFGNTQGPSRVAQFLVIYAPRRGILEVWNTQQGPRVGAFNVGKHCRLLYPGYKIMGLNNVTSQSWQPQTYQICLVDPVSASVKAVNVPFHLALSDKKSERAKDLHLVKKLSALLRAKSPRPDSFETEIKELILDIKYPATKKQALESILASDRLSFSCLRNVTQTLMDTLKNQELESVDEGLLQFCASKLKLLHLYESVSQLNTLDFHSDTPFSDNDLAVLLRLDDKELLKLRALLEKYKQENTKATVRFSEDADRVLPVKTFLEYLEYEKDALSIRKIGEEECVALGSFFFWKCLHGKSSTEEMCHSLESAGLSPQQLLSLLLSVWLSKEKDILDKPQSVCCLHTMLSLLSKMKVAIDETWDSQSVSPWWQQMRMACIQSENSGAALLSAHVGHSVAAQMSSGATDKKFSQMELDADAEALTDSWEALSLDTEYWKLLLRQLEDCLILQTLLHSKLSPPAAKAPSLQSEPLPRLSVKKLLEGGKGGIADSVAKWIFKQDLSPELLKCANKERDVENPDEPREDLLHLAYEQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFLVRSIEHLKQILNPHVQNGIALMMWNTFLVKRFSAATYLMDKVGKSPKDRLCRRDVGMSDTALTSFLGSCLELLQTSLEADISRDEVQVPVLDTEDAWLSVEGPISIVELALEQKPIHYPLVEHHSVLCSILYASMRFSLKSVKPLALFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQAQHSKDKDPSAEAANTHWKDLNWPGLAVDLAHHLQVSDDVIRRHYVGELYSHGADLLGEEAIFQVQDKEVLASQLLVLTGQRLAHALFHTQTKEGMELLARLPPTLCTWLKAMNPQDLQNTGVPIAATAKLVHKVMELLPEKHGQYSLALHLIDAVEAMATL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	FPHLREETPGALKRD HHHHHCCCCCCCCCC	23.44	29899451
38	Phosphorylation	GALKRDPSKTSSWED CCCCCCCCCCCCCCC	53.51	22817900
40	Phosphorylation	LKRDPSKTSSWEDDS CCCCCCCCCCCCCCC	32.12	21082442
41	Phosphorylation	KRDPSKTSSWEDDSW CCCCCCCCCCCCCCC	36.87	19060867
42	Phosphorylation	RDPSKTSSWEDDSWG CCCCCCCCCCCCCCC	39.45	25338131
352	Phosphorylation	SGWLGWKSKHEEDTV HCCCCCCCCCCHHCH	32.51	29899451
448	Phosphorylation	VPEKGGFSPFGNTQG CCCCCCCCCCCCCCC	23.69	25521595
453	Phosphorylation	GFSPFGNTQGPSRVA CCCCCCCCCCHHHHH	34.97	28833060
457	Phosphorylation	FGNTQGPSRVAQFLV CCCCCCHHHHHHEEE	46.33	28833060
559	Phosphorylation	LHLVKKLSALLRAKS HHHHHHHHHHHHCCC	26.25	22817900
566	Phosphorylation	SALLRAKSPRPDSFE HHHHHCCCCCCCCHH	25.75	25521595
571	Phosphorylation	AKSPRPDSFETEIKE CCCCCCCCHHHHHHH	27.89	25159016
574	Phosphorylation	PRPDSFETEIKELIL CCCCCHHHHHHHHHH	40.79	25159016
675	Ubiquitination	VLLRLDDKELLKLRA EEEECCHHHHHHHHH	50.34	-
814	Phosphorylation	DETWDSQSVSPWWQQ CCCCCCCCCCHHHHH	28.63	23649490
899	Phosphorylation	EDCLILQTLLHSKLS HHHHHHHHHHHCCCC	28.04	-
903	Phosphorylation	ILQTLLHSKLSPPAA HHHHHHHCCCCCCHH	34.95	29899451
914	Phosphorylation	PPAAKAPSLQSEPLP CCHHHCCCCCCCCCC	43.85	-
946	Ubiquitination	SVAKWIFKQDLSPEL HHHHHHHHCCCCHHH	33.49	-
950	Phosphorylation	WIFKQDLSPELLKCA HHHHCCCCHHHHHHH	25.31	21454597
1189	Phosphorylation	EMDPNFISVRQQFLL CCCCCCEEHHHHHHH	13.70	28059163
1294	Phosphorylation	LAHALFHTQTKEGME HHHHHHHCCCHHHHH	30.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RBGPR_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBGPR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBGPR_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RBGPR_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448, AND MASSSPECTROMETRY.
PubMed: 17114649