| UniProt ID | MTP_MOUSE | |
|---|---|---|
| UniProt AC | O08601 | |
| Protein Name | Microsomal triglyceride transfer protein large subunit | |
| Gene Name | Mttp | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 894 | |
| Subcellular Localization |
Isoform 1: Endoplasmic reticulum. Localized to the endoplasmic reticulum (PubMed:17312007). Colocalizes with P4HB/PDI in the endoplasmic reticulum (By similarity). Isoform 2: Endoplasmic reticulum. Golgi apparatus. Localized to the endoplasmic |
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| Protein Description | Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins. Loads phospholipid into the C1D1 antigen-binding groove. Isoform 2 is critical for the development of natural killer T (NKT) cells. May have a role in the biogenesis of lipid droplets.. | |
| Protein Sequence | MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFLDGGKGKPQDSVGYKISSDVDVVLLWRNPDGDDDQVIQVTITAVNVENAGQQRGEKSIFQGKSTPKIIGKDNLEALQRPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSGFTTANQVLGVSSKATSVTTYKIEDSFVTAVLAEETRAFALNFQQTIAGKIVSKQKLELKTTEAGPRMIPGKQVAGVIKAVDSKYKAIPIVGQVLERVCKGCPSLAEHWKSIRKNLEPENLSKAEAVQSFLAFIQHLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPDSLEAILDFLDFKSDSSIILQERFLYACGFATHPDEELLRALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAVVEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPVSHLATTVLQRYDVSFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNPSYMDVKNILLSIGELPKEMNKYMLTVVQDILHFEMPASKMIRRVLKEMAVHNYDRFSKSGSSSAYTGYVERSPRAASTYSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDIQLQSGLKANMEIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDVTVDASFVKAGVESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTGRGYVSRRRKESLVAGCELPLHQENSEMCNVVFPPQPESDNSGGWF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 38 | Phosphorylation | ERLYKLTYSTEVFLD CEEEEEEEEEEEEEE | 24.83 | 28576409 | |
| 105 | Succinylation | EKSIFQGKSTPKIIG CCCCCCCCCCCCCCC | 40.13 | 23954790 | |
| 113 | Acetylation | STPKIIGKDNLEALQ CCCCCCCCCHHHHHH | 32.79 | 6566415 | |
| 149 | Succinylation | PVGIENLKRGLASLF CCCHHHHHHHHHHHH | 56.87 | 23954790 | |
| 184 | Acetylation | TYQAQQDKVVKIKAL EEEECCCCEEEEEEC | 44.59 | 23201123 | |
| 199 (in isoform 2) | Acetylation | - | 26.01 | - | |
| 271 | Ubiquitination | GPRMIPGKQVAGVIK CCCCCCCCHHHHHHH | 35.92 | 22790023 | |
| 271 (in isoform 2) | Ubiquitination | - | 35.92 | 22790023 | |
| 278 | Acetylation | KQVAGVIKAVDSKYK CHHHHHHHHHCCCCC | 39.69 | 23201123 | |
| 286 (in isoform 2) | Ubiquitination | - | 15.08 | - | |
| 293 (in isoform 2) | Acetylation | - | 5.02 | - | |
| 321 | Phosphorylation | NLEPENLSKAEAVQS HCCCCCCCHHHHHHH | 41.21 | 20469934 | |
| 352 | Acetylation | LQILKAEKKEVLPQL HHHHHHHHHCHHHHH | 60.12 | 23864654 | |
| 397 | S-palmitoylation | QERFLYACGFATHPD HHHHHHHCCCCCCCC | 2.66 | 28526873 | |
| 416 | Succinylation | RALLSKFKGSFASND HHHHHHCCCCCCCCC | 58.33 | 23954790 | |
| 448 | Succinylation | QNEGCKLKAVVEAKK HCCCCCCHHHHHHHH | 25.32 | 23954790 | |
| 463 | Acetylation | LILGGLEKPEKKEDT HHHCCCCCCCCCCHH | 64.62 | 23201123 | |
| 470 | Phosphorylation | KPEKKEDTTMYLLAL CCCCCCHHHHHHHHH | 17.98 | 28066266 | |
| 471 | Phosphorylation | PEKKEDTTMYLLALK CCCCCHHHHHHHHHH | 19.01 | 28066266 | |
| 473 | Phosphorylation | KKEDTTMYLLALKNA CCCHHHHHHHHHHHC | 9.11 | 28066266 | |
| 478 (in isoform 2) | Acetylation | - | 34.27 | - | |
| 521 | Acetylation | SFITDEVKKTLNRIY CCCCHHHHHHHHHHH | 37.68 | 23201123 | |
| 521 | Succinylation | SFITDEVKKTLNRIY CCCCHHHHHHHHHHH | 37.68 | 23954790 | |
| 536 (in isoform 2) | Acetylation | - | 54.10 | - | |
| 562 | Phosphorylation | DVKNILLSIGELPKE CHHHHHHHHCCCCHH | 25.71 | 21659604 | |
| 609 | Ubiquitination | HNYDRFSKSGSSSAY CCCHHCCCCCCCCCC | 57.00 | 22790023 | |
| 609 (in isoform 2) | Ubiquitination | - | 57.00 | 22790023 | |
| 624 (in isoform 2) | Ubiquitination | - | 35.83 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MTP_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MTP_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MTP_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MTP_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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