CNDP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNDP2_MOUSE
• UniProt AC: Q9D1A2
• Protein Name: Cytosolic non-specific dipeptidase
• Gene Name: Cndp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 475
• Subcellular Localization: Cytoplasm .
• Protein Description: Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis..
• Protein Sequence: MSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMMEVAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEAYQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDNYWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISLMGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETLLHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPDMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQAGRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRLNYIEGTKMLAAYLYEVSQLKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MSALKAVFQYID ---CCHHHHHHHHHH	42.07	22790023
20	Acetylation	ENQDRYVKKLAEWVA CCCHHHHHHHHHHHH	32.89	23954790
20	Ubiquitination	ENQDRYVKKLAEWVA CCCHHHHHHHHHHHH	32.89	22790023
58	Phosphorylation	DVQRLGGSVELVDIG HHHHHCCEEEEEECC	15.60	27180971
68	Ubiquitination	LVDIGKQKLPDGSEI EEECCCCCCCCCCCC	66.53	22790023
87	Phosphorylation	ILLGKLGSDPQKKTV HHHHCCCCCCCCCEE	57.46	-
150	Phosphorylation	ALEAYQKTGQEIPVN HHHHHHHHCCCCCCC	28.68	26239621
168	Phosphorylation	CLEGMEESGSEGLDE HHHCCHHHCCCCHHH	34.02	26239621
192	S-palmitoylation	FKDVDYVCISDNYWL CCCCCEEEEECCEEE	1.69	28680068
205	Glutathionylation	WLGKNKPCITYGLRG EECCCCCCEEECCCC	3.76	24333276
295	Phosphorylation	AKDVGAETLLHSCKK HHHHCHHHHHHHHHH	33.80	-
299	Phosphorylation	GAETLLHSCKKDILM CHHHHHHHHHHHHHH	27.83	25266776
300	Glutathionylation	AETLLHSCKKDILMH HHHHHHHHHHHHHHH	4.40	24333276
300	S-nitrosylation	AETLLHSCKKDILMH HHHHHHHHHHHHHHH	4.40	24926564
301	Ubiquitination	ETLLHSCKKDILMHR HHHHHHHHHHHHHHC	57.40	22790023
339	Ubiquitination	IPRKVVGKFSIRLVP EECEEECEEEEEECC	25.07	22790023
359	Phosphorylation	VVSEQVSSYLSKKFA HHHHHHHHHHHHHHH	31.10	30352176
363	Succinylation	QVSSYLSKKFAELQS HHHHHHHHHHHHCCC	49.68	23954790
364	Ubiquitination	VSSYLSKKFAELQSP HHHHHHHHHHHCCCC	46.56	-
364	Acetylation	VSSYLSKKFAELQSP HHHHHHHHHHHCCCC	46.56	23806337
364	Malonylation	VSSYLSKKFAELQSP HHHHHHHHHHHCCCC	46.56	26320211
370	Phosphorylation	KKFAELQSPNKFKVY HHHHHCCCCCCEEEE	42.96	22817900
402	Malonylation	QAGRRALKTVFGVEP HHHHHHHHHHHCCCC	41.48	26320211
402	Ubiquitination	QAGRRALKTVFGVEP HHHHHHHHHHHCCCC	41.48	-
403	Phosphorylation	AGRRALKTVFGVEPD HHHHHHHHHHCCCCC	23.16	28059163
430	Ubiquitination	TFQEATGKNVMLLPV EEEECCCCCEEEEEC	41.85	22790023
450	Ubiquitination	GAHSQNEKLNRLNYI CCCCCCHHHHHCHHC	59.62	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNDP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNDP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNDP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CNDP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.