SFTPD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SFTPD_MOUSE
• UniProt AC: P50404
• Protein Name: Pulmonary surfactant-associated protein D
• Gene Name: Sftpd
• Organism: Mus musculus (Mouse).
• Sequence Length: 374
• Subcellular Localization: Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
• Protein Description: Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties..
• Protein Sequence: MLPFLSMLVLLVQPLGNLGAEMKSLSQRSVPNTCTLVMCSPTENGLPGRDGRDGREGPRGEKGDPGLPGPMGLSGLQGPTGPVGPKGENGSAGEPGPKGERGLSGPPGLPGIPGPAGKEGPSGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSTGAKGSTGPKGERGAPGVQGAPGNAGAAGPAGPAGPQGAPGSRGPPGLKGDRGVPGDRGIKGESGLPDSAALRQQMEALKGKLQRLEVAFSHYQKAALFPDGRSVGDKIFRTADSEKPFEDAQEMCKQAGGQLASPRSATENAAIQQLITAHNKAAFLSMTDVGTEGKFTYPTGEPLVYSNWAPGEPNNNGGAENCVEIFTNGQWNDKACGEQRLVICEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	S-nitrosocysteine	QRSVPNTCTLVMCSP HCCCCCEEEEEECCC	3.35	-
34	S-nitrosylation	QRSVPNTCTLVMCSP HCCCCCEEEEEECCC	3.35	-
39	S-nitrosocysteine	NTCTLVMCSPTENGL CEEEEEECCCCCCCC	3.25	-
39	S-nitrosylation	NTCTLVMCSPTENGL CEEEEEECCCCCCCC	3.25	-
89	N-linked_Glycosylation	PVGPKGENGSAGEPG CCCCCCCCCCCCCCC	59.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SFTPD_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
34	C	S-nitrosylation	S-nitrosylation at Cys-34 and Cys-39 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.	-
39	C	S-nitrosylation	S-nitrosylation at Cys-34 and Cys-39 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SFTPD_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SFTPD_MOUSE	Sftpd	physical	11278637

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.