P4HA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P4HA1_MOUSE
• UniProt AC: Q60715
• Protein Name: Prolyl 4-hydroxylase subunit alpha-1
• Gene Name: P4ha1
• Organism: Mus musculus (Mouse).
• Sequence Length: 534
• Subcellular Localization: Endoplasmic reticulum lumen.
• Protein Description: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins..
• Protein Sequence: MIWVVLMMAILLPQSLAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKDMSDGFISNLTIQRQYFPNDEDQVGAAKALFRLQDTYNLDTNTISKGNLPGVQHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALTQLEEGELSTVDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIMSKEKDANKSASGDQSDQKTAPKKKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLRRATISNPVTGALETVHYRISKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	MAILLPQSLAHPGFF HHHHHHHHHCCCCCC	26.11	28059163
29	Phosphorylation	FTSIGQMTDLIHNEK CCCHHHHHHHHHCCH	21.55	28059163
43	Acetylation	KDLVTSLKDYIKAEE HHHHHHHHHHHHHHH	48.53	22826441
52	Acetylation	YIKAEEDKLEQIKKW HHHHHHHHHHHHHHH	58.15	23806337
62	Acetylation	QIKKWAEKLDRLTST HHHHHHHHHHHHHHC	48.19	22826441
67	Phosphorylation	AEKLDRLTSTATKDP HHHHHHHHHCCCCCC	25.56	20139300
68	Phosphorylation	EKLDRLTSTATKDPE HHHHHHHHCCCCCCC	22.19	20139300
69	Phosphorylation	KLDRLTSTATKDPEG HHHHHHHCCCCCCCC	32.86	20139300
72	Acetylation	RLTSTATKDPEGFVG HHHHCCCCCCCCCCC	69.67	6584967
89	Acetylation	VNAFKLMKRLNTEWS HHHHHHHHHHCCCHH	65.26	6584973
107	Phosphorylation	NLILKDMSDGFISNL HHHHHCCCCCCCCCC	44.72	29899451
113	N-linked_Glycosylation	MSDGFISNLTIQRQY CCCCCCCCCEEEECC	36.07	-
150	Acetylation	LDTNTISKGNLPGVQ CCCCCCCCCCCCCCC	48.22	22826441
259	N-linked_Glycosylation	MSKEKDANKSASGDQ EEHHHCCCCCCCCCC	49.28	-
293	Glutathionylation	RQKYEMLCRGEGIKM HHHHHHHHCCCCCCC	5.18	24333276
299	Acetylation	LCRGEGIKMTPRRQK HHCCCCCCCCHHHCC	47.80	23806337
299	Succinylation	LCRGEGIKMTPRRQK HHCCCCCCCCHHHCC	47.80	23806337
320	Acetylation	HDGNRNPKFILAPAK CCCCCCCCEEEEECC	48.89	22826441
345	Phosphorylation	IRFHDIISDAEIEIV EEHHHHCCHHHHHHH	30.97	26525534
353	Acetylation	DAEIEIVKDLAKPRL HHHHHHHHHHCCHHC	53.32	22826441
364	Phosphorylation	KPRLRRATISNPVTG CHHCCCCEECCCCCC	24.11	26060331
366	Phosphorylation	RLRRATISNPVTGAL HCCCCEECCCCCCCH	30.63	28418008
382	Acetylation	TVHYRISKSAWLSGY HHEEEECCCHHHCCC	41.65	22826441
411	Phosphorylation	LTGLDVSTAEELQVA CCCCCCCCHHHHCHH	37.63	28059163
420	Phosphorylation	EELQVANYGVGGQYE HHHCHHCCCCCCCCC	11.94	28059163
503	Glutathionylation	YSTRHAACPVLVGNK HHHCCCCCCEEECCC	2.19	24333276
510	Acetylation	CPVLVGNKWVSNKWL CCEEECCCCCCCHHH	42.94	22826441
515	Acetylation	GNKWVSNKWLHERGQ CCCCCCCHHHHHHHH	43.56	22826441
531	Phosphorylation	FRRPCTLSELE---- HCCCCCHHHCC----	23.21	26525534

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P4HA1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P4HA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P4HA1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of P4HA1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.